CRISP1 — 51 ClinVar variants
All ClinVar germline CRISP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
8 Likely benign · 43 Uncertain significance
Full CRISP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRISP1 p.Ala75Thr Uncertain significance Single submitter
- CRISP1 p.Arg162Cys Uncertain significance Single submitter
- CRISP1 p.Arg27Thr Uncertain significance Single submitter
- CRISP1 p.Asp136Glu Uncertain significance Single submitter
- CRISP1 p.Asp137His Uncertain significance Single submitter
- CRISP1 p.Asp204Gly Uncertain significance Single submitter
- CRISP1 p.Asp36Asn Uncertain significance Single submitter
- CRISP1 p.Cys161Ser Uncertain significance Single submitter
- CRISP1 p.Cys207Ser Uncertain significance Single submitter
- CRISP1 p.Gln164Glu Uncertain significance Single submitter
- CRISP1 p.Glu247Asp Uncertain significance Single submitter
- CRISP1 p.Gly155Asp Uncertain significance Single submitter
- CRISP1 p.His128Arg Uncertain significance Single submitter
- CRISP1 p.Ile158Leu Uncertain significance Single submitter
- CRISP1 p.Ile212Val Uncertain significance Single submitter
- CRISP1 p.Leu6Ile Uncertain significance Single submitter
- CRISP1 p.Lys23Asn Uncertain significance Single submitter
- CRISP1 p.Lys24Arg Uncertain significance Single submitter
- CRISP1 p.Lys32Asn Uncertain significance Single submitter
- CRISP1 p.Met84Thr Uncertain significance Single submitter
- CRISP1 p.Met84Val Uncertain significance Single submitter
- CRISP1 p.Ser121Ile Uncertain significance Single submitter
- CRISP1 p.Ser125Asn Uncertain significance Single submitter
- CRISP1 p.Ser79Ala Uncertain significance Single submitter
- CRISP1 p.Thr124Arg Uncertain significance Single submitter
- CRISP1 p.Thr132Arg Uncertain significance Single submitter
- CRISP1 p.Thr246Ile Uncertain significance Single submitter
- CRISP1 p.Val147Phe Uncertain significance Single submitter
- CRISP1 p.Val193Ile Uncertain significance Single submitter
- CRISP1 p.Val34Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CRISP1 p.Ala71Thr Uncertain significance Single submitter
- CRISP1 p.Cys195Gly Uncertain significance Single submitter
- CRISP1 p.Cys207Phe Uncertain significance Single submitter
- CRISP1 p.Cys238Gly Uncertain significance Single submitter
- CRISP1 p.Cys238Ser Uncertain significance Single submitter
- CRISP1 p.Cys99Ser Uncertain significance Single submitter
- CRISP1 p.Gln41Pro Uncertain significance Single submitter
- CRISP1 p.Gly179Arg Uncertain significance Single submitter
- CRISP1 p.Met62Val Uncertain significance Single submitter
- CRISP1 p.Pro188Thr Uncertain significance Single submitter
- CRISP1 p.Tyr217Cys Uncertain significance Single submitter
- CRISP1 p.Val172Leu Uncertain significance Single submitter
- CRISP1 p.Val45Phe Uncertain significance Single submitter
All CRISP1 variants
Likely benign 8
- p.Arg168Gln Single submitter
- p.Arg92= Single submitter
- p.Asn49= Single submitter
- p.Cys14Gly Single submitter
- p.Ile222Leu Single submitter
- p.Ile47Val Single submitter
- p.Lys80Arg Single submitter
- p.Val172Ile Single submitter
Uncertain significance 43
- p.Ala71Thr Single submitter ⚠
- p.Ala75Thr Single submitter ⚠
- p.Arg162Cys Single submitter ⚠
- p.Arg27Thr Single submitter ⚠
- p.Asp136Glu Single submitter ⚠
- p.Asp137His Single submitter ⚠
- p.Asp204Gly Single submitter ⚠
- p.Asp36Asn Single submitter ⚠
- p.Cys161Ser Single submitter ⚠
- p.Cys195Gly Single submitter ⚠
- p.Cys207Phe Single submitter ⚠
- p.Cys207Ser Single submitter ⚠
- p.Cys238Gly Single submitter ⚠
- p.Cys238Ser Single submitter ⚠
- p.Cys99Ser Single submitter ⚠
- p.Gln164Glu Single submitter ⚠
- p.Gln41Pro Single submitter ⚠
- p.Glu247Asp Single submitter ⚠
- p.Gly155Asp Single submitter ⚠
- p.Gly179Arg Single submitter ⚠
- p.His128Arg Single submitter ⚠
- p.Ile158Leu Single submitter ⚠
- p.Ile212Val Single submitter ⚠
- p.Leu6Ile Single submitter ⚠
- p.Lys23Asn Single submitter ⚠
- p.Lys24Arg Single submitter ⚠
- p.Lys32Asn Single submitter ⚠
- p.Met62Val Single submitter ⚠
- p.Met84Thr Single submitter ⚠
- p.Met84Val Single submitter ⚠
- p.Pro188Thr Single submitter ⚠
- p.Ser121Ile Single submitter ⚠
- p.Ser125Asn Single submitter ⚠
- p.Ser79Ala Single submitter ⚠
- p.Thr124Arg Single submitter ⚠
- p.Thr132Arg Single submitter ⚠
- p.Thr246Ile Single submitter ⚠
- p.Tyr217Cys Single submitter ⚠
- p.Val147Phe Single submitter ⚠
- p.Val172Leu Single submitter ⚠
- p.Val193Ile Single submitter ⚠
- p.Val34Ile Single submitter ⚠
- p.Val45Phe Single submitter ⚠