CRK — 35 ClinVar variants
All ClinVar germline CRK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 30 flagged for review →
3 Benign · 2 Likely benign · 30 Uncertain significance
Full CRK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 30
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRK p.Ala240Thr Uncertain significance Single submitter
- CRK p.Ala76Val Uncertain significance Single submitter
- CRK p.Asn171His Uncertain significance Single submitter
- CRK p.Gln244Arg Uncertain significance Single submitter
- CRK p.Gln77Lys Uncertain significance Single submitter
- CRK p.Glu9Asp Uncertain significance Single submitter
- CRK p.Gly126Arg Uncertain significance Single submitter
- CRK p.Gly126Val Uncertain significance Single submitter
- CRK p.Gly202Ala Uncertain significance Single submitter
- CRK p.Gly203Ser Uncertain significance Single submitter
- CRK p.Ile269Met Uncertain significance Single submitter
- CRK p.Pro152Ser Uncertain significance Single submitter
- CRK p.Pro216Gln Uncertain significance Single submitter
- CRK p.Pro229Leu Uncertain significance Single submitter
- CRK p.Pro299Ser Uncertain significance Single submitter
- CRK p.Pro72Leu Uncertain significance Single submitter
- CRK p.Ser175Arg Uncertain significance Single submitter
- CRK p.Ser304Asn Uncertain significance Single submitter
- CRK p.Thr113Met Uncertain significance Single submitter
- CRK p.Tyr251Cys Uncertain significance Single submitter
- CRK p.Val264Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- CRK p.Ala222Asp Uncertain significance Single submitter
- CRK p.Arg10Trp Uncertain significance Single submitter
- CRK p.Arg283Gln Uncertain significance Single submitter
- CRK p.Arg292His Uncertain significance Single submitter
- CRK p.Asn227Lys Uncertain significance Single submitter
- CRK p.Ile115Arg Uncertain significance Single submitter
- CRK p.Leu230Pro Uncertain significance Single submitter
- CRK p.Leu233Arg Uncertain significance Single submitter
- CRK p.Pro73Arg Uncertain significance Single submitter
All CRK variants
Uncertain significance 30
- p.Ala222Asp Single submitter ⚠
- p.Ala240Thr Single submitter ⚠
- p.Ala76Val Single submitter ⚠
- p.Arg10Trp Single submitter ⚠
- p.Arg283Gln Single submitter ⚠
- p.Arg292His Single submitter ⚠
- p.Asn171His Single submitter ⚠
- p.Asn227Lys Single submitter ⚠
- p.Gln244Arg Single submitter ⚠
- p.Gln77Lys Single submitter ⚠
- p.Glu9Asp Single submitter ⚠
- p.Gly126Arg Single submitter ⚠
- p.Gly126Val Single submitter ⚠
- p.Gly202Ala Single submitter ⚠
- p.Gly203Ser Single submitter ⚠
- p.Ile115Arg Single submitter ⚠
- p.Ile269Met Single submitter ⚠
- p.Leu230Pro Single submitter ⚠
- p.Leu233Arg Single submitter ⚠
- p.Pro152Ser Single submitter ⚠
- p.Pro216Gln Single submitter ⚠
- p.Pro229Leu Single submitter ⚠
- p.Pro299Ser Single submitter ⚠
- p.Pro72Leu Single submitter ⚠
- p.Pro73Arg Single submitter ⚠
- p.Ser175Arg Single submitter ⚠
- p.Ser304Asn Single submitter ⚠
- p.Thr113Met Single submitter ⚠
- p.Tyr251Cys Single submitter ⚠
- p.Val264Leu Single submitter ⚠