CRMP1 — 123 ClinVar variants
All ClinVar germline CRMP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
1 Likely pathogenic · 9 Benign · 6 Likely benign · 107 Uncertain significance
Full CRMP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRMP1 p.Ala199Ser Uncertain significance Single submitter
-
CRMP1 p.Ala209Val
Uncertain significance
Single submitter
CRMP1-related neurodevelopmental disorder
- CRMP1 p.Ala298Val Uncertain significance Single submitter
- CRMP1 p.Ala587Thr Uncertain significance Single submitter
- CRMP1 p.Ala630Thr Uncertain significance Single submitter
- CRMP1 p.Ala658Ser Uncertain significance Single submitter
- CRMP1 p.Arg359Gln Uncertain significance Single submitter
- CRMP1 p.Asn470Ile Uncertain significance Single submitter
- CRMP1 p.Asn663Asp Uncertain significance Single submitter
- CRMP1 p.Asp141Tyr Uncertain significance Single submitter
- CRMP1 p.Asp529Asn Uncertain significance Single submitter
- CRMP1 p.Asp661Gly Uncertain significance Single submitter
- CRMP1 p.Gln289Lys Uncertain significance Single submitter
- CRMP1 p.Gln321Lys Uncertain significance Single submitter
- CRMP1 p.Gln594Arg Uncertain significance Single submitter
- CRMP1 p.Glu335Lys Uncertain significance Single submitter
- CRMP1 p.Gly446Ser Uncertain significance Single submitter
- CRMP1 p.Gly669Ser Uncertain significance Single submitter
- CRMP1 p.His591Gln Uncertain significance Single submitter
- CRMP1 p.His591Leu Uncertain significance Single submitter
- CRMP1 p.His640Tyr Uncertain significance Single submitter
- CRMP1 p.Ile360Thr Uncertain significance Single submitter
- CRMP1 p.Ile393Leu Uncertain significance Single submitter
- CRMP1 p.Ile645Val Uncertain significance Single submitter
- CRMP1 p.Ile660Leu Uncertain significance Single submitter
- CRMP1 p.Leu151Val Uncertain significance Single submitter
- CRMP1 p.Lys530Met Uncertain significance Single submitter
- CRMP1 p.Met579Val Uncertain significance Single submitter
- CRMP1 p.Pro589Ser Uncertain significance Single submitter
- CRMP1 p.Ser445Gly Uncertain significance Single submitter
- CRMP1 p.Thr402Asn Uncertain significance Single submitter
- CRMP1 p.Tyr509Cys Uncertain significance Single submitter
- CRMP1 p.Val149Ile Uncertain significance Single submitter
- CRMP1 p.Val308Met Uncertain significance Single submitter
- CRMP1 p.Val596Ile Uncertain significance Single submitter
Predictors split 43
The independent predictors disagree with each other — read with care.
- CRMP1 p.Ala174Val Uncertain significance Single submitter
- CRMP1 p.Ala199Val Uncertain significance Single submitter
- CRMP1 p.Arg137Gln Uncertain significance Single submitter
- CRMP1 p.Arg177Trp Uncertain significance Single submitter
- CRMP1 p.Arg263Leu Uncertain significance Single submitter
- CRMP1 p.Arg263Trp Uncertain significance Single submitter
- CRMP1 p.Arg325Gln Uncertain significance Single submitter
- CRMP1 p.Arg325Gly Uncertain significance Single submitter
- CRMP1 p.Arg581Cys Uncertain significance Single submitter
- CRMP1 p.Arg585Gln Uncertain significance Single submitter
- CRMP1 p.Arg599Lys Uncertain significance Single submitter
- CRMP1 p.Asn461Thr Uncertain significance Single submitter
- CRMP1 p.Asn501Ser Uncertain significance Single submitter
- CRMP1 p.Asn600Thr Uncertain significance Single submitter
- CRMP1 p.Asp153Asn Uncertain significance Single submitter
- CRMP1 p.Asp260Asn Uncertain significance Single submitter
- CRMP1 p.Asp376Asn Uncertain significance Single submitter
- CRMP1 p.Asp439Glu Uncertain significance Single submitter
- CRMP1 p.Asp460His Uncertain significance Single submitter
- CRMP1 p.Asp661Glu Uncertain significance Single submitter
- CRMP1 p.Glu235Lys Uncertain significance Single submitter
- CRMP1 p.Glu467Ala Uncertain significance Single submitter
- CRMP1 p.Glu544Gln Uncertain significance Single submitter
- CRMP1 p.Glu619Asp Uncertain significance Single submitter
- CRMP1 p.Glu619Lys Uncertain significance Single submitter
- CRMP1 p.Ile133Leu Uncertain significance Single submitter
- CRMP1 p.Ile534Val Uncertain significance Single submitter
- CRMP1 p.Lys236Asn Uncertain significance Single submitter
- CRMP1 p.Lys384Glu Uncertain significance Single submitter
- CRMP1 p.Met329Ile Uncertain significance Single submitter
- CRMP1 p.Met551Val Uncertain significance Single submitter
- CRMP1 p.Phe301Leu Uncertain significance Single submitter
- CRMP1 p.Pro342Ser Uncertain significance Single submitter
- CRMP1 p.Pro584Leu Uncertain significance Single submitter
- CRMP1 p.Pro584Ser Uncertain significance Single submitter
- CRMP1 p.Ser373Thr Uncertain significance Single submitter
- CRMP1 p.Ser680Cys Uncertain significance Single submitter
- CRMP1 p.Thr256Ile Uncertain significance Single submitter
- CRMP1 p.Thr332Met Uncertain significance Single submitter
- CRMP1 p.Thr367Ala Uncertain significance Single submitter
- CRMP1 p.Tyr146His Uncertain significance Single submitter
- CRMP1 p.Tyr296Cys Uncertain significance Single submitter
- CRMP1 p.Val275Ile Uncertain significance Single submitter
All CRMP1 variants
Likely pathogenic 1
- p.Lys586fs No assertion criteria
Benign 9
- c.820+8A>G Multiple submitters
- c.964-8T>C Multiple submitters
- p.Ala357= Multiple submitters
- p.Gly261Arg Multiple submitters
- p.Val524= Multiple submitters
- p.Gly607= Single submitter
- p.Pro466= Single submitter
- p.Ser233= Single submitter
- p.Thr355= Single submitter
Likely benign 6
Uncertain significance 107
- p.Ala174Val Single submitter ⚠
- p.Ala199Ser Single submitter ⚠
- p.Ala199Val Single submitter ⚠
- p.Ala209Val Single submitter CRMP1-related neurodevelopmental disorder ⚠
- p.Ala298Val Single submitter ⚠
- p.Ala37Thr Single submitter
- p.Ala587Thr Single submitter ⚠
- p.Ala630Thr Single submitter ⚠
- p.Ala658Ser Single submitter ⚠
- p.Ala67Ser Single submitter
- p.Ala72fs Single submitter
- p.Ala72Gly Single submitter
- p.Ala7Thr Single submitter
- p.Arg123Gln Single submitter
- p.Arg137Gln Single submitter ⚠
- p.Arg177Trp Single submitter ⚠
- p.Arg263Leu Single submitter ⚠
- p.Arg263Trp Single submitter ⚠
- p.Arg325Gln Single submitter ⚠
- p.Arg325Gly Single submitter ⚠
- p.Arg359Gln Single submitter ⚠
- p.Arg581Cys Single submitter ⚠
- p.Arg585Gln Single submitter ⚠
- p.Arg599Lys Single submitter ⚠
- p.Asn461Thr Single submitter ⚠
- p.Asn470Ile Single submitter ⚠
- p.Asn501Ser Single submitter ⚠
- p.Asn600Thr Single submitter ⚠
- p.Asn663Asp Single submitter ⚠
- p.Asp118Val Single submitter
- p.Asp141Tyr Single submitter ⚠
- p.Asp153Asn Single submitter ⚠
- p.Asp260Asn Single submitter ⚠
- p.Asp376Asn Single submitter ⚠
- p.Asp439Glu Single submitter ⚠
- p.Asp460His Single submitter ⚠
- p.Asp529Asn Single submitter ⚠
- p.Asp661Glu Single submitter ⚠
- p.Asp661Gly Single submitter ⚠
- p.Asp87Asn Single submitter
- p.Gln26Arg Single submitter
- p.Gln289Lys Single submitter ⚠
- p.Gln321Lys Single submitter ⚠
- p.Gln594Arg Single submitter ⚠
- p.Glu235Lys Single submitter ⚠
- p.Glu335Lys Single submitter ⚠
- p.Glu467Ala Single submitter ⚠
- p.Glu544Gln Single submitter ⚠
- p.Glu619Asp Single submitter ⚠
- p.Glu619Lys Single submitter ⚠
- p.Gly33Cys Single submitter
- p.Gly41Asp Single submitter
- p.Gly446Ser Single submitter ⚠
- p.Gly669Ser Single submitter ⚠
- p.Gly74Trp Single submitter
- p.Gly79Glu Single submitter
- p.Gly93Arg Single submitter
- p.His591Gln Single submitter ⚠
- p.His591Leu Single submitter ⚠
- p.His640Tyr Single submitter ⚠
- p.Ile133Leu Single submitter ⚠
- p.Ile360Thr Single submitter ⚠
- p.Ile393Leu Single submitter ⚠
- p.Ile534Val Single submitter ⚠
- p.Ile645Val Single submitter ⚠
- p.Ile660Leu Single submitter ⚠
- p.Leu121Val Single submitter
- p.Leu151Val Single submitter ⚠
- p.Lys236Asn Single submitter ⚠
- p.Lys384Glu Single submitter ⚠
- p.Lys530Met Single submitter ⚠
- p.Met329Ile Single submitter ⚠
- p.Met551Val Single submitter ⚠
- p.Met579Val Single submitter ⚠
- p.Phe301Leu Single submitter ⚠
- p.Phe36Leu Single submitter
- p.Phe50Leu Single submitter
- p.Pro114His Single submitter
- p.Pro28Leu Single submitter
- p.Pro342Ser Single submitter ⚠
- p.Pro584Leu Single submitter ⚠
- p.Pro584Ser Single submitter ⚠
- p.Pro589Ser Single submitter ⚠
- p.Pro99Ser Single submitter
- p.Ser373Thr Single submitter ⚠
- p.Ser445Gly Single submitter ⚠
- p.Ser60Ala Single submitter
- p.Ser680Cys Single submitter ⚠
- p.Ser81Ile Single submitter
- p.Ser97Ile Single submitter
- p.Thr256Ile Single submitter ⚠
- p.Thr27Asn Single submitter
- p.Thr27Ile Single submitter
- p.Thr332Met Single submitter ⚠
- p.Thr367Ala Single submitter ⚠
- p.Thr402Asn Single submitter ⚠
- p.Trp526Ter Single submitter neurodevelopmental disorder
- p.Trp8Cys Single submitter
- p.Tyr146His Single submitter ⚠
- p.Tyr296Cys Single submitter ⚠
- p.Tyr509Cys Single submitter ⚠
- p.Val149Ile Single submitter ⚠
- p.Val275Ile Single submitter ⚠
- p.Val308Met Single submitter ⚠
- p.Val596Ile Single submitter ⚠
- p.Val73Gly Single submitter
- p.Val88Gly Single submitter