CROCC — 550 ClinVar variants

All ClinVar germline CROCC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 481 flagged for review →

2 Conflicting · 8 Benign · 2 Benign/Likely benign · 44 Likely benign · 494 Uncertain significance

Full CROCC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 481

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 386

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 386

Predictors split 94

The independent predictors disagree with each other — read with care.

All CROCC variants

Conflicting classifications of pathogenicity 2

Benign 8

Benign/Likely benign 2

Likely benign 44

Uncertain significance 494

Showing the top 300 by review status; the full set is in the sitemap.