CRTAM — 55 ClinVar variants
All ClinVar germline CRTAM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
6 Benign · 4 Likely benign · 45 Uncertain significance
Full CRTAM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRTAM p.Ala315Val Uncertain significance Single submitter
- CRTAM p.Asn132Ser Uncertain significance Single submitter
- CRTAM p.Asn275Ser Uncertain significance Single submitter
- CRTAM p.Cys98Gly Uncertain significance Single submitter
- CRTAM p.Gln204Arg Uncertain significance Single submitter
- CRTAM p.Gln277Arg Uncertain significance Single submitter
- CRTAM p.Glu259Lys Uncertain significance Single submitter
- CRTAM p.Glu324Lys Uncertain significance Single submitter
- CRTAM p.Glu62Asp Uncertain significance Single submitter
- CRTAM p.His100Leu Uncertain significance Single submitter
- CRTAM p.His316Tyr Uncertain significance Single submitter
- CRTAM p.His385Asn Uncertain significance Single submitter
- CRTAM p.Ile288Val Uncertain significance Single submitter
- CRTAM p.Ile303Val Uncertain significance Single submitter
- CRTAM p.Leu14Ser Uncertain significance Single submitter
- CRTAM p.Leu74Phe Uncertain significance Single submitter
- CRTAM p.Lys373Thr Uncertain significance Single submitter
- CRTAM p.Pro118Leu Uncertain significance Single submitter
- CRTAM p.Pro238Ser Uncertain significance Single submitter
- CRTAM p.Pro268Arg Uncertain significance Single submitter
- CRTAM p.Ser181Arg Uncertain significance Single submitter
- CRTAM p.Ser352Phe Uncertain significance Single submitter
- CRTAM p.Ser391Arg Uncertain significance Single submitter
- CRTAM p.Thr143Ile Uncertain significance Single submitter
- CRTAM p.Thr223Ile Uncertain significance Single submitter
- CRTAM p.Thr264Ala Uncertain significance Single submitter
- CRTAM p.Thr33Met Uncertain significance Single submitter
- CRTAM p.Thr52Asn Uncertain significance Single submitter
- CRTAM p.Trp154Cys Uncertain significance Single submitter
- CRTAM p.Tyr360Cys Uncertain significance Single submitter
- CRTAM p.Val114Gly Uncertain significance Single submitter
- CRTAM p.Val245Ala Uncertain significance Single submitter
- CRTAM p.Val305Ile Uncertain significance Single submitter
- CRTAM p.Val317Met Uncertain significance Single submitter
- CRTAM p.Val376Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CRTAM p.Asp173Gly Benign Multiple submitters
- CRTAM p.Arg213Trp Uncertain significance Single submitter
- CRTAM p.Glu29Gly Uncertain significance Single submitter
- CRTAM p.Thr166Lys Uncertain significance Single submitter
- CRTAM p.Thr193Ala Uncertain significance Single submitter
- CRTAM p.Thr193Met Uncertain significance Single submitter
- CRTAM p.Val5Asp Uncertain significance Single submitter
All CRTAM variants
Benign 6
- p.Ala78Asp Multiple submitters
- p.Asp173Gly Multiple submitters ⚠
- p.Glu16Ala Multiple submitters
- p.Thr193= Multiple submitters
- p.Thr253Ile Multiple submitters
- p.Lys147= Single submitter
Likely benign 4
- p.Asp103Asn Single submitter
- p.Gly189Ser Single submitter
- p.Ser163Tyr Single submitter
- p.Ser46Ala Single submitter
Uncertain significance 45
- p.Ala315Val Single submitter ⚠
- p.Arg213Trp Single submitter ⚠
- p.Asn132Ser Single submitter ⚠
- p.Asn275Ser Single submitter ⚠
- p.Cys98Gly Single submitter ⚠
- p.Gln204Arg Single submitter ⚠
- p.Gln277Arg Single submitter ⚠
- p.Glu259Lys Single submitter ⚠
- p.Glu29Gly Single submitter ⚠
- p.Glu324Lys Single submitter ⚠
- p.Glu62Asp Single submitter ⚠
- p.His100Leu Single submitter ⚠
- p.His316Tyr Single submitter ⚠
- p.His385Asn Single submitter ⚠
- p.Ile288Val Single submitter ⚠
- p.Ile303Val Single submitter ⚠
- p.Ile309Thr Single submitter
- p.Leu14Ser Single submitter ⚠
- p.Leu74Phe Single submitter ⚠
- p.Lys373Thr Single submitter ⚠
- p.Pro118Leu Single submitter ⚠
- p.Pro238Ser Single submitter ⚠
- p.Pro268Arg Single submitter ⚠
- p.Ser181Arg Single submitter ⚠
- p.Ser181Asn Single submitter
- p.Ser332Ile Single submitter
- p.Ser352Phe Single submitter ⚠
- p.Ser391Arg Single submitter ⚠
- p.Thr143Ile Single submitter ⚠
- p.Thr166Lys Single submitter ⚠
- p.Thr193Ala Single submitter ⚠
- p.Thr193Met Single submitter ⚠
- p.Thr223Ile Single submitter ⚠
- p.Thr264Ala Single submitter ⚠
- p.Thr33Met Single submitter ⚠
- p.Thr52Asn Single submitter ⚠
- p.Trp154Cys Single submitter ⚠
- p.Trp3Cys Single submitter
- p.Tyr360Cys Single submitter ⚠
- p.Val114Gly Single submitter ⚠
- p.Val245Ala Single submitter ⚠
- p.Val305Ile Single submitter ⚠
- p.Val317Met Single submitter ⚠
- p.Val376Ile Single submitter ⚠
- p.Val5Asp Single submitter ⚠