CRTC2 — 78 ClinVar variants
All ClinVar germline CRTC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →
1 Likely benign · 77 Uncertain significance
Full CRTC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 76
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRTC2 p.Ala676Gly Uncertain significance Single submitter
- CRTC2 p.Arg119His Uncertain significance Single submitter
- CRTC2 p.Arg144Gln Uncertain significance Single submitter
- CRTC2 p.Arg428His Uncertain significance Single submitter
- CRTC2 p.Arg429His Uncertain significance Single submitter
- CRTC2 p.Arg51Pro Uncertain significance Single submitter
- CRTC2 p.Arg527Thr Uncertain significance Single submitter
- CRTC2 p.Arg58Gln Uncertain significance Single submitter
- CRTC2 p.Arg659His Uncertain significance Single submitter
- CRTC2 p.Arg691Gln Uncertain significance Single submitter
- CRTC2 p.Asn151Ser Uncertain significance Single submitter
- CRTC2 p.Asn351Ser Uncertain significance Single submitter
- CRTC2 p.Asp210Glu Uncertain significance Single submitter
- CRTC2 p.Glu246Asp Uncertain significance Single submitter
- CRTC2 p.Glu642Gly Uncertain significance Single submitter
- CRTC2 p.Glu657Asp Uncertain significance Single submitter
- CRTC2 p.Gly48Ser Uncertain significance Single submitter
- CRTC2 p.Gly637Arg Uncertain significance Single submitter
- CRTC2 p.His426Asn Uncertain significance Single submitter
- CRTC2 p.His530Tyr Uncertain significance Single submitter
- CRTC2 p.His542Gln Uncertain significance Single submitter
- CRTC2 p.His598Arg Uncertain significance Single submitter
- CRTC2 p.His66Pro Uncertain significance Single submitter
- CRTC2 p.His89Tyr Uncertain significance Single submitter
- CRTC2 p.Leu118Val Uncertain significance Single submitter
- CRTC2 p.Lys212Arg Uncertain significance Single submitter
- CRTC2 p.Met459Ile Uncertain significance Single submitter
- CRTC2 p.Met459Val Uncertain significance Single submitter
- CRTC2 p.Met551Lys Uncertain significance Single submitter
- CRTC2 p.Met551Val Uncertain significance Single submitter
- CRTC2 p.Phe40Val Uncertain significance Single submitter
- CRTC2 p.Pro139Ser Uncertain significance Single submitter
- CRTC2 p.Pro417Ser Uncertain significance Single submitter
- CRTC2 p.Pro485Leu Uncertain significance Single submitter
- CRTC2 p.Pro499Ser Uncertain significance Single submitter
- CRTC2 p.Pro537Ser Uncertain significance Single submitter
- CRTC2 p.Ser358Asn Uncertain significance Single submitter
- CRTC2 p.Ser492Gly Uncertain significance Single submitter
- CRTC2 p.Ser628Phe Uncertain significance Single submitter
- CRTC2 p.Thr13Met Uncertain significance Single submitter
- CRTC2 p.Val470Ile Uncertain significance Single submitter
- CRTC2 p.Val517Ala Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- CRTC2 p.Ala374Val Uncertain significance Single submitter
- CRTC2 p.Arg241Gln Uncertain significance Single submitter
- CRTC2 p.Arg549Gln Uncertain significance Single submitter
- CRTC2 p.Arg549Trp Uncertain significance Single submitter
- CRTC2 p.Arg688Cys Uncertain significance Single submitter
- CRTC2 p.Arg691Leu Uncertain significance Single submitter
- CRTC2 p.Asn181Lys Uncertain significance Single submitter
- CRTC2 p.Asn73Ser Uncertain significance Single submitter
- CRTC2 p.Gly651Glu Uncertain significance Single submitter
- CRTC2 p.His312Tyr Uncertain significance Single submitter
- CRTC2 p.Leu220Phe Uncertain significance Single submitter
- CRTC2 p.Leu221Ile Uncertain significance Single submitter
- CRTC2 p.Leu338Phe Uncertain significance Single submitter
- CRTC2 p.Lys56Glu Uncertain significance Single submitter
- CRTC2 p.Met314Val Uncertain significance Single submitter
- CRTC2 p.Phe562Leu Uncertain significance Single submitter
- CRTC2 p.Pro137Arg Uncertain significance Single submitter
- CRTC2 p.Pro395Leu Uncertain significance Single submitter
- CRTC2 p.Pro421Ser Uncertain significance Single submitter
- CRTC2 p.Pro425Leu Uncertain significance Single submitter
- CRTC2 p.Pro434Thr Uncertain significance Single submitter
- CRTC2 p.Pro615Arg Uncertain significance Single submitter
- CRTC2 p.Pro87Leu Uncertain significance Single submitter
- CRTC2 p.Ser386Phe Uncertain significance Single submitter
- CRTC2 p.Ser403Phe Uncertain significance Single submitter
- CRTC2 p.Ser405Cys Uncertain significance Single submitter
- CRTC2 p.Ser408Phe Uncertain significance Single submitter
- CRTC2 p.Ser436Cys Uncertain significance Single submitter
- CRTC2 p.Ser566Arg Uncertain significance Single submitter
- CRTC2 p.Ser570Arg Uncertain significance Single submitter
- CRTC2 p.Ser609Cys Uncertain significance Single submitter
- CRTC2 p.Ser613Leu Uncertain significance Single submitter
- CRTC2 p.Ser86Asn Uncertain significance Single submitter
- CRTC2 p.Thr385Ile Uncertain significance Single submitter
All CRTC2 variants
Likely benign 1
- p.Thr192Ala Single submitter
Uncertain significance 77
- p.Ala374Val Single submitter ⚠
- p.Ala676Gly Single submitter ⚠
- p.Arg119His Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Arg428His Single submitter ⚠
- p.Arg429His Single submitter ⚠
- p.Arg51Pro Single submitter ⚠
- p.Arg527Thr Single submitter ⚠
- p.Arg549Gln Single submitter ⚠
- p.Arg549Trp Single submitter ⚠
- p.Arg58Gln Single submitter ⚠
- p.Arg659His Single submitter ⚠
- p.Arg688Cys Single submitter ⚠
- p.Arg691Gln Single submitter ⚠
- p.Arg691Leu Single submitter ⚠
- p.Asn151Ser Single submitter ⚠
- p.Asn181Lys Single submitter ⚠
- p.Asn351Ser Single submitter ⚠
- p.Asn73Ser Single submitter ⚠
- p.Asp210Glu Single submitter ⚠
- p.Glu246Asp Single submitter ⚠
- p.Glu642Gly Single submitter ⚠
- p.Glu657Asp Single submitter ⚠
- p.Gly48Ser Single submitter ⚠
- p.Gly637Arg Single submitter ⚠
- p.Gly651Glu Single submitter ⚠
- p.His312Tyr Single submitter ⚠
- p.His426Asn Single submitter ⚠
- p.His530Tyr Single submitter ⚠
- p.His542Gln Single submitter ⚠
- p.His598Arg Single submitter ⚠
- p.His66Pro Single submitter ⚠
- p.His89Tyr Single submitter ⚠
- p.Leu118Val Single submitter ⚠
- p.Leu220Phe Single submitter ⚠
- p.Leu221Ile Single submitter ⚠
- p.Leu338Phe Single submitter ⚠
- p.Lys212Arg Single submitter ⚠
- p.Lys56Glu Single submitter ⚠
- p.Met314Val Single submitter ⚠
- p.Met459Ile Single submitter ⚠
- p.Met459Val Single submitter ⚠
- p.Met551Lys Single submitter ⚠
- p.Met551Val Single submitter ⚠
- p.Phe40Val Single submitter ⚠
- p.Phe562Leu Single submitter ⚠
- p.Pro137Arg Single submitter ⚠
- p.Pro139Ser Single submitter ⚠
- p.Pro395Leu Single submitter ⚠
- p.Pro417Ser Single submitter ⚠
- p.Pro421Ser Single submitter ⚠
- p.Pro425Leu Single submitter ⚠
- p.Pro434Thr Single submitter ⚠
- p.Pro485Leu Single submitter ⚠
- p.Pro499Ser Single submitter ⚠
- p.Pro537Ser Single submitter ⚠
- p.Pro615Arg Single submitter ⚠
- p.Pro87Leu Single submitter ⚠
- p.Ser358Asn Single submitter ⚠
- p.Ser386Phe Single submitter ⚠
- p.Ser403Phe Single submitter ⚠
- p.Ser405Cys Single submitter ⚠
- p.Ser408Phe Single submitter ⚠
- p.Ser436Cys Single submitter ⚠
- p.Ser492Gly Single submitter ⚠
- p.Ser566Arg Single submitter ⚠
- p.Ser570Arg Single submitter ⚠
- p.Ser609Cys Single submitter ⚠
- p.Ser613Leu Single submitter ⚠
- p.Ser628Phe Single submitter ⚠
- p.Ser86Asn Single submitter ⚠
- p.Thr13Met Single submitter ⚠
- p.Thr385Ile Single submitter ⚠
- p.Val470Ile Single submitter ⚠
- p.Val517Ala Single submitter ⚠
- p.Arg58Ter No assertion criteria