CRY1 — 73 ClinVar variants
All ClinVar germline CRY1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
2 Benign · 8 Likely benign · 63 Uncertain significance
Full CRY1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRY1 p.Arg256Gln Uncertain significance Multiple submitters
- CRY1 p.Thr179Ala Uncertain significance Multiple submitters
- CRY1 p.Ala111Thr Uncertain significance Single submitter
- CRY1 p.Ala5Gly Uncertain significance Single submitter
- CRY1 p.Arg32Cys Uncertain significance Single submitter
- CRY1 p.Arg493Gln Uncertain significance Single submitter
- CRY1 p.Arg67Gln Uncertain significance Single submitter
- CRY1 p.Arg72Cys Uncertain significance Single submitter
- CRY1 p.Asp29Gly Uncertain significance Single submitter
- CRY1 p.Asp341Asn Uncertain significance Single submitter
- CRY1 p.Asp543Glu Uncertain significance Single submitter
- CRY1 p.Gln26Arg Uncertain significance Single submitter
- CRY1 p.Gln26His Uncertain significance Single submitter
- CRY1 p.Glu140Lys Uncertain significance Single submitter
- CRY1 p.Gly419Arg Uncertain significance Single submitter
- CRY1 p.His186Arg Uncertain significance Single submitter
- CRY1 p.His186Asp Uncertain significance Single submitter
- CRY1 p.His548Gln Uncertain significance Single submitter
- CRY1 p.Ile128Leu Uncertain significance Single submitter
- CRY1 p.Ile25Leu Uncertain significance Single submitter
- CRY1 p.Ile31Val Uncertain significance Single submitter
- CRY1 p.Ile392Leu Uncertain significance Single submitter
- CRY1 p.Leu195Pro Uncertain significance Single submitter
- CRY1 p.Leu218Arg Uncertain significance Single submitter
- CRY1 p.Leu260Met Uncertain significance Single submitter
- CRY1 p.Leu260Trp Uncertain significance Single submitter
- CRY1 p.Leu291Ser Uncertain significance Single submitter
- CRY1 p.Lys268Arg Uncertain significance Single submitter
- CRY1 p.Met557Val Uncertain significance Single submitter
- CRY1 p.Pro193Ser Uncertain significance Single submitter
- CRY1 p.Pro467Thr Uncertain significance Single submitter
- CRY1 p.Pro567Ser Uncertain significance Single submitter
- CRY1 p.Ser391Gly Uncertain significance Single submitter
- CRY1 p.Ser527Gly Uncertain significance Single submitter
- CRY1 p.Ser556Cys Uncertain significance Single submitter
- CRY1 p.Thr169Arg Uncertain significance Single submitter
- CRY1 p.Thr559Ser Uncertain significance Single submitter
- CRY1 p.Tyr150Phe Uncertain significance Single submitter
- CRY1 p.Tyr428Cys Uncertain significance Single submitter
- CRY1 p.Tyr488Cys Uncertain significance Single submitter
- CRY1 p.Val167Ala Uncertain significance Single submitter
- CRY1 p.Val209Ala Uncertain significance Single submitter
-
CRY1 p.Ala342Thr
Uncertain significance
No assertion criteria
CRY1-related disorder
Predictors split 15
The independent predictors disagree with each other — read with care.
- CRY1 p.Ala241Val Uncertain significance Single submitter
- CRY1 p.Arg14Gln Uncertain significance Single submitter
- CRY1 p.Asn50Ser Uncertain significance Single submitter
- CRY1 p.Asp423Gly Uncertain significance Single submitter
- CRY1 p.Glu325Gln Uncertain significance Single submitter
- CRY1 p.Glu452Gly Uncertain significance Single submitter
- CRY1 p.Gly438Val Uncertain significance Single submitter
- CRY1 p.Lys308Glu Uncertain significance Single submitter
- CRY1 p.Phe409Cys Uncertain significance Single submitter
- CRY1 p.Pro253Ala Uncertain significance Single submitter
- CRY1 p.Pro39Ser Uncertain significance Single submitter
- CRY1 p.Ser158Arg Uncertain significance Single submitter
- CRY1 p.Thr345Ile Uncertain significance Single submitter
- CRY1 p.Val503Ala Uncertain significance Single submitter
-
CRY1 p.Val6Met
Uncertain significance
Single submitter
delayed sleep phase syndrome, susceptibility to
All CRY1 variants
Likely benign 8
- c.410+17T>A Single submitter
- c.595+13T>G Single submitter
- p.Gly2= Single submitter
- p.Gly212= Single submitter
- p.Pro146= Single submitter
- c.-5C>T No assertion criteria CRY1-related disorder
- p.Ala299= No assertion criteria CRY1-related disorder
- p.Gly533= No assertion criteria CRY1-related disorder
Uncertain significance 63
- p.Arg256Gln Multiple submitters ⚠
- p.Thr179Ala Multiple submitters ⚠
- p.Ala111Thr Single submitter ⚠
- p.Ala241Val Single submitter ⚠
- p.Ala331Gly Single submitter
- p.Ala5Gly Single submitter ⚠
- p.Arg14Gln Single submitter ⚠
- p.Arg256Ter Single submitter CRY1-related disorder
- p.Arg32Cys Single submitter ⚠
- p.Arg493Gln Single submitter ⚠
- p.Arg67Gln Single submitter ⚠
- p.Arg72Cys Single submitter ⚠
- p.Asn18Ser Single submitter
- p.Asn50Ser Single submitter ⚠
- p.Asp29Gly Single submitter ⚠
- p.Asp341Asn Single submitter ⚠
- p.Asp423Gly Single submitter ⚠
- p.Asp543Glu Single submitter ⚠
- p.Gln26Arg Single submitter ⚠
- p.Gln26His Single submitter ⚠
- p.Gln490Arg Single submitter
- p.Glu140Lys Single submitter ⚠
- p.Glu325Gln Single submitter ⚠
- p.Glu452Gly Single submitter ⚠
- p.Gly144Arg Single submitter
- p.Gly419Arg Single submitter ⚠
- p.Gly438Val Single submitter ⚠
- p.His186Arg Single submitter ⚠
- p.His186Asp Single submitter ⚠
- p.His548Gln Single submitter ⚠
- p.Ile128Leu Single submitter ⚠
- p.Ile25Leu Single submitter ⚠
- p.Ile31Val Single submitter ⚠
- p.Ile392Leu Single submitter ⚠
- p.Leu195Pro Single submitter ⚠
- p.Leu218Arg Single submitter ⚠
- p.Leu260Met Single submitter ⚠
- p.Leu260Trp Single submitter ⚠
- p.Leu291Ser Single submitter ⚠
- p.Lys268Arg Single submitter ⚠
- p.Lys308Glu Single submitter ⚠
- p.Met557Val Single submitter ⚠
- p.Phe409Cys Single submitter ⚠
- p.Pro193Ser Single submitter ⚠
- p.Pro253Ala Single submitter ⚠
- p.Pro39Ser Single submitter ⚠
- p.Pro467Thr Single submitter ⚠
- p.Pro567Ser Single submitter ⚠
- p.Ser158Arg Single submitter ⚠
- p.Ser391Gly Single submitter ⚠
- p.Ser527Gly Single submitter ⚠
- p.Ser556Cys Single submitter ⚠
- p.Thr169Arg Single submitter ⚠
- p.Thr345Ile Single submitter ⚠
- p.Thr559Ser Single submitter ⚠
- p.Tyr150Phe Single submitter ⚠
- p.Tyr428Cys Single submitter ⚠
- p.Tyr488Cys Single submitter ⚠
- p.Val167Ala Single submitter ⚠
- p.Val209Ala Single submitter ⚠
- p.Val503Ala Single submitter ⚠
- p.Val6Met Single submitter delayed sleep phase syndrome, susceptibility to ⚠
- p.Ala342Thr No assertion criteria CRY1-related disorder ⚠