CRYGA — 49 ClinVar variants
All ClinVar germline CRYGA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
1 Conflicting · 3 Benign · 4 Likely benign · 41 Uncertain significance
Full CRYGA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRYGA p.Arg27Trp Uncertain significance Single submitter
- CRYGA p.Arg48His Uncertain significance Single submitter
- CRYGA p.Asp161Asn Uncertain significance Single submitter
- CRYGA p.Asp97Asn Uncertain significance Single submitter
- CRYGA p.Glu128Gln Uncertain significance Single submitter
- CRYGA p.His155Gln Uncertain significance Single submitter
- CRYGA p.Leu105Val Uncertain significance Single submitter
- CRYGA p.Lys62Asn Uncertain significance Single submitter
- CRYGA p.Pro24Ser Uncertain significance Single submitter
- CRYGA p.Ser40Arg Uncertain significance Single submitter
- CRYGA p.Ser86Asn Uncertain significance Single submitter
- CRYGA p.Ser86Thr Uncertain significance Single submitter
- CRYGA p.Trp131Leu Uncertain significance Single submitter
- CRYGA p.Trp157Cys Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- CRYGA p.Ala110Thr Uncertain significance Single submitter
- CRYGA p.Arg140Gln Uncertain significance Single submitter
- CRYGA p.Arg140Leu Uncertain significance Single submitter
- CRYGA p.Arg142Gln Uncertain significance Single submitter
- CRYGA p.Arg153Ser Uncertain significance Single submitter
- CRYGA p.Arg15His Uncertain significance Single submitter
- CRYGA p.Arg169Gln Uncertain significance Single submitter
- CRYGA p.Arg169Trp Uncertain significance Single submitter
- CRYGA p.Arg48Cys Uncertain significance Single submitter
- CRYGA p.Arg60Gln Uncertain significance Single submitter
- CRYGA p.Arg80Cys Uncertain significance Single submitter
-
CRYGA p.Arg80His
Conflicting
Single submitter
CRYGA-related disorder
- CRYGA p.Arg99Gln Uncertain significance Single submitter
- CRYGA p.Asp150Asn Uncertain significance Single submitter
- CRYGA p.Asp172Asn Uncertain significance Single submitter
- CRYGA p.Asp74Asn Uncertain significance Single submitter
- CRYGA p.Cys16Tyr Uncertain significance Single submitter
- CRYGA p.Gln77Arg Likely benign Single submitter
- CRYGA p.Gly149Arg Uncertain significance Single submitter
- CRYGA p.Gly158Trp Uncertain significance Single submitter
- CRYGA p.Gly159Val Uncertain significance Single submitter
- CRYGA p.Gly165Ser Uncertain significance Single submitter
- CRYGA p.Gly2Glu Uncertain significance Single submitter
- CRYGA p.His54Asp Uncertain significance Single submitter
- CRYGA p.Met44Leu Uncertain significance Single submitter
- CRYGA p.Pro83Arg Uncertain significance Single submitter
- CRYGA p.Ser87Leu Uncertain significance Single submitter
- CRYGA p.Tyr134Cys Uncertain significance Single submitter
- CRYGA p.Tyr134Phe Uncertain significance Single submitter
All CRYGA variants
Conflicting classifications of pathogenicity 1
- p.Arg80His Single submitter CRYGA-related disorder ⚠
Benign 3
- p.Arg99Ter Multiple submitters
- p.Asn18Ile No assertion criteria CRYGA-related disorder
- p.Pro119= No assertion criteria CRYGA-related disorder
Likely benign 4
- p.Arg27Gln Single submitter
- p.Gln77Arg Single submitter ⚠
- p.Cys130Tyr No assertion criteria CRYGA-related disorder
- p.Leu58= No assertion criteria CRYGA-related disorder
Uncertain significance 41
- p.Ala110Thr Single submitter ⚠
- p.Arg140Gln Single submitter ⚠
- p.Arg140Leu Single submitter ⚠
- p.Arg142Gln Single submitter ⚠
- p.Arg153Ser Single submitter ⚠
- p.Arg15His Single submitter ⚠
- p.Arg169Gln Single submitter ⚠
- p.Arg169Trp Single submitter ⚠
- p.Arg27Trp Single submitter ⚠
- p.Arg48Cys Single submitter ⚠
- p.Arg48His Single submitter ⚠
- p.Arg60Gln Single submitter ⚠
- p.Arg80Cys Single submitter ⚠
- p.Arg99Gln Single submitter ⚠
- p.Asp150Asn Single submitter ⚠
- p.Asp161Asn Single submitter ⚠
- p.Asp172Asn Single submitter ⚠
- p.Asp74Asn Single submitter ⚠
- p.Asp97Asn Single submitter ⚠
- p.Cys16Tyr Single submitter ⚠
- p.Glu128Gln Single submitter ⚠
- p.Gly149Arg Single submitter ⚠
- p.Gly158Trp Single submitter ⚠
- p.Gly159Val Single submitter ⚠
- p.Gly165Ser Single submitter ⚠
- p.Gly2Glu Single submitter ⚠
- p.His155Gln Single submitter ⚠
- p.His54Asp Single submitter ⚠
- p.Leu105Val Single submitter ⚠
- p.Lys62Asn Single submitter ⚠
- p.Met44Leu Single submitter ⚠
- p.Pro24Ser Single submitter ⚠
- p.Pro83Arg Single submitter ⚠
- p.Ser40Arg Single submitter ⚠
- p.Ser86Asn Single submitter ⚠
- p.Ser86Thr Single submitter ⚠
- p.Ser87Leu Single submitter ⚠
- p.Trp131Leu Single submitter ⚠
- p.Trp157Cys Single submitter ⚠
- p.Tyr134Cys Single submitter ⚠
- p.Tyr134Phe Single submitter ⚠