Sugi Variant

Sugi Variant/CRYGS

CRYGS — 68 ClinVar variants

All ClinVar germline CRYGS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →

4 Pathogenic · 3 Likely pathogenic · 3 Conflicting · 5 Benign · 1 Benign/Likely benign · 7 Likely benign · 45 Uncertain significance

Full CRYGS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 41

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 30

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 8

The independent predictors disagree with each other — read with care.

All CRYGS variants

Pathogenic 4

Likely pathogenic 3

Conflicting classifications of pathogenicity 3

Benign 5

Benign/Likely benign 1

  • p.Gly102= Multiple submitters cataract 20 multiple types

Likely benign 7

Uncertain significance 45