CRYL1 — 115 ClinVar variants
All ClinVar germline CRYL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 41 flagged for review →
69 Benign · 6 Likely benign · 40 Uncertain significance
Full CRYL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 41
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRYL1 p.Arg171Ser Uncertain significance Single submitter
- CRYL1 p.Arg231Trp Uncertain significance Single submitter
- CRYL1 p.Arg298Met Uncertain significance Single submitter
- CRYL1 p.Asn48Asp Uncertain significance Single submitter
- CRYL1 p.Asp110His Uncertain significance Single submitter
- CRYL1 p.Asp114Gly Uncertain significance Single submitter
- CRYL1 p.Cys252Arg Uncertain significance Single submitter
- CRYL1 p.Gln264Arg Uncertain significance Single submitter
- CRYL1 p.Glu157Gly Uncertain significance Single submitter
- CRYL1 p.His90Asn Uncertain significance Single submitter
- CRYL1 p.Ile113Thr Uncertain significance Single submitter
- CRYL1 p.Leu55Met Uncertain significance Single submitter
- CRYL1 p.Lys102Asn Uncertain significance Single submitter
- CRYL1 p.Met307Ile Uncertain significance Single submitter
- CRYL1 p.Pro146Ser Uncertain significance Single submitter
- CRYL1 p.Pro149Leu Uncertain significance Single submitter
- CRYL1 p.Pro289Ser Uncertain significance Single submitter
- CRYL1 p.Pro292Leu Uncertain significance Single submitter
- CRYL1 p.Ser67Arg Uncertain significance Single submitter
- CRYL1 p.Trp207Arg Uncertain significance Single submitter
- CRYL1 p.Val223Asp Uncertain significance Single submitter
- CRYL1 p.Val223Phe Uncertain significance Single submitter
- CRYL1 p.Val316Leu Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- CRYL1 p.Ala45Thr Uncertain significance Single submitter
- CRYL1 p.Arg171Ile Uncertain significance Single submitter
- CRYL1 p.Arg185Gln Uncertain significance Single submitter
- CRYL1 p.Asp253Asn Uncertain significance Single submitter
- CRYL1 p.Glu246Gly Uncertain significance Single submitter
- CRYL1 p.Gly64Asp Uncertain significance Single submitter
- CRYL1 p.His137Arg Uncertain significance Single submitter
- CRYL1 p.Ile179Thr Uncertain significance Single submitter
- CRYL1 p.Ile235Thr Uncertain significance Single submitter
- CRYL1 p.Leu222Phe Uncertain significance Single submitter
- CRYL1 p.Met248Thr Uncertain significance Single submitter
- CRYL1 p.Pro162Arg Uncertain significance Single submitter
- CRYL1 p.Pro162Leu Uncertain significance Single submitter
- CRYL1 p.Pro270Leu Uncertain significance Single submitter
- CRYL1 p.Ser218Cys Uncertain significance Single submitter
- CRYL1 p.Ser73Thr Uncertain significance Single submitter
- CRYL1 p.Val156Ile Uncertain significance Single submitter
-
CRYL1 p.Gly134Ser
Benign
No assertion criteria
CRYL1-related disorder
All CRYL1 variants
Benign 69
- c.149+24A>G Multiple submitters
- c.276+13C>T Multiple submitters
- c.41+65T>G Multiple submitters
- c.438+49G>T Multiple submitters
- c.438+62C>T Multiple submitters
- c.439-40A>G Multiple submitters
- c.634-202T>C Multiple submitters
- c.846+110A>G Multiple submitters
- c.847-123G>A Multiple submitters
- p.Ala84= Multiple submitters
- p.Asn44= Multiple submitters
- p.Gly87= Multiple submitters
- c.149+209T>C Single submitter
- c.150-195G>A Single submitter
- c.150-3445T>C Single submitter
- c.150-3528G>A Single submitter
- c.150-3576T>C Single submitter
- c.150-3631A>G Single submitter
- c.150-3686C>G Single submitter
- c.150-3772A>C Single submitter
- c.276+10988A>G Single submitter
- c.276+11013G>A Single submitter
- c.276+1156T>C Single submitter
- c.276+1231C>T Single submitter
- c.276+15651G>A Single submitter
- c.276+15773G>A Single submitter
- c.276+20613G>A Single submitter
- c.276+20662A>G Single submitter
- c.276+21003G>A Single submitter
- c.276+6613CA[12] Single submitter
- c.277-102T>G Single submitter
- c.277-202G>A Single submitter
- c.277-23654del Single submitter
- c.277-23715G>C Single submitter
- c.277-23750G>A Single submitter
- c.277-23765T>C Single submitter
- c.277-23961A>G Single submitter
- c.277-24009C>T Single submitter
- c.277-9053A>G Single submitter
- c.438+312C>T Single submitter
- c.438+426C>T Single submitter
- c.438+45C>T Single submitter
- c.438+47G>T Single submitter
- c.438+538dup Single submitter
- c.633+2727T>C Single submitter
- c.633+3039C>G Single submitter
- c.633+7621T>C Single submitter
- c.633+7804G>C Single submitter
- c.633+8038G>A Single submitter
- c.634-1106T>C Single submitter
- c.634-1273C>T Single submitter
- c.634-137C>T Single submitter
- c.634-5733C>T Single submitter
- c.634-841GT[10] Single submitter
- c.634-841GT[12] Single submitter
- c.634-841GT[8] Single submitter
- c.634-841GT[9] Single submitter
- c.634-868_634-867insC Single submitter
- c.634-868A>C Single submitter
- c.634-870C>A Single submitter
- c.634-872C>A Single submitter
- c.634-890CA[12] Single submitter
- c.740-147C>T Single submitter
- c.740-148G>T Single submitter
- c.740-224C>T Single submitter
- c.740-84CT[2] Single submitter
- c.846+159C>T Single submitter
- p.Gly134Ser No assertion criteria CRYL1-related disorder ⚠
- p.Leu24= No assertion criteria CRYL1-related disorder
Likely benign 6
- p.Ile202Val Single submitter
- p.Ser218Gly Single submitter
- p.Ser314Arg Single submitter
- p.Thr167Ala Single submitter
- p.Gly77= No assertion criteria CRYL1-related disorder
- p.Thr265= No assertion criteria CRYL1-related disorder
Uncertain significance 40
- p.Ala45Thr Single submitter ⚠
- p.Arg171Ile Single submitter ⚠
- p.Arg171Ser Single submitter ⚠
- p.Arg185Gln Single submitter ⚠
- p.Arg231Trp Single submitter ⚠
- p.Arg298Met Single submitter ⚠
- p.Asn48Asp Single submitter ⚠
- p.Asp110His Single submitter ⚠
- p.Asp114Gly Single submitter ⚠
- p.Asp253Asn Single submitter ⚠
- p.Cys252Arg Single submitter ⚠
- p.Gln264Arg Single submitter ⚠
- p.Glu157Gly Single submitter ⚠
- p.Glu246Gly Single submitter ⚠
- p.Gly64Asp Single submitter ⚠
- p.His137Arg Single submitter ⚠
- p.His90Asn Single submitter ⚠
- p.Ile113Thr Single submitter ⚠
- p.Ile179Thr Single submitter ⚠
- p.Ile235Thr Single submitter ⚠
- p.Leu222Phe Single submitter ⚠
- p.Leu55Met Single submitter ⚠
- p.Lys102Asn Single submitter ⚠
- p.Met248Thr Single submitter ⚠
- p.Met307Ile Single submitter ⚠
- p.Pro146Ser Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Pro162Arg Single submitter ⚠
- p.Pro162Leu Single submitter ⚠
- p.Pro270Leu Single submitter ⚠
- p.Pro289Ser Single submitter ⚠
- p.Pro292Leu Single submitter ⚠
- p.Ser218Cys Single submitter ⚠
- p.Ser67Arg Single submitter ⚠
- p.Ser73Thr Single submitter ⚠
- p.Trp207Arg Single submitter ⚠
- p.Val156Ile Single submitter ⚠
- p.Val223Asp Single submitter ⚠
- p.Val223Phe Single submitter ⚠
- p.Val316Leu Single submitter ⚠