CRYM — 137 ClinVar variants
All ClinVar germline CRYM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
9 Conflicting · 28 Benign · 2 Benign/Likely benign · 39 Likely benign · 59 Uncertain significance
Full CRYM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CRYM p.Glu172Gly Uncertain significance Multiple submitters
- CRYM p.Thr95Ser Uncertain significance Multiple submitters
-
CRYM p.Val4Leu
Uncertain significance
Multiple submitters
autosomal dominant nonsyndromic hearing loss 40
- CRYM p.Arg56Ser Uncertain significance Single submitter
- CRYM p.Arg83Gly Uncertain significance Single submitter
- CRYM p.Gln44Arg Uncertain significance Single submitter
- CRYM p.Glu184Lys Uncertain significance Single submitter
- CRYM p.Glu209Gln Uncertain significance Single submitter
- CRYM p.Gly183Arg Uncertain significance Single submitter
-
CRYM p.Gly84Asp
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 40
- CRYM p.Gly84Ser Uncertain significance Single submitter
- CRYM p.Ile211Ser Uncertain significance Single submitter
- CRYM p.Leu17Pro Uncertain significance Single submitter
- CRYM p.Lys132Asn Uncertain significance Single submitter
- CRYM p.Lys162Arg Uncertain significance Single submitter
- CRYM p.Thr105Ile Uncertain significance Single submitter
- CRYM p.Thr203Ile Uncertain significance Single submitter
- CRYM p.Thr48Pro Uncertain significance Single submitter
- CRYM p.Thr86Asn Uncertain significance Single submitter
- CRYM p.Val181Leu Uncertain significance Single submitter
- CRYM p.Val185Ile Uncertain significance Single submitter
- CRYM p.Val248Met Uncertain significance Single submitter
- CRYM p.Val279Leu Uncertain significance Single submitter
- CRYM p.Val297Ala Uncertain significance Single submitter
- CRYM p.Val46Leu Uncertain significance Single submitter
-
CRYM p.Asp260His
Uncertain significance
No assertion criteria
CRYM-related disorder
Predictors split 32
The independent predictors disagree with each other — read with care.
- CRYM p.Ala178Glu Uncertain significance Multiple submitters
-
CRYM p.Ala303Thr
Uncertain significance
Multiple submitters
autosomal dominant nonsyndromic hearing loss 40
- CRYM p.Glu274Gln Benign/Likely benign Multiple submitters
-
CRYM p.Ile141Val
Uncertain significance
Multiple submitters
autosomal dominant nonsyndromic hearing loss 40
- CRYM p.Leu72Val Uncertain significance Multiple submitters
- CRYM p.Met295Ile Uncertain significance Multiple submitters
- CRYM p.Ala108Thr Uncertain significance Single submitter
- CRYM p.Ala108Val Uncertain significance Single submitter
-
CRYM p.Ala10Gly
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 40
- CRYM p.Ala194Thr Uncertain significance Single submitter
- CRYM p.Ala221Val Likely benign Single submitter
-
CRYM p.Ala254Val
Conflicting
Single submitter
autosomal dominant nonsyndromic hearing loss 40
- CRYM p.Arg186Gln Conflicting Single submitter
- CRYM p.Arg18Cys Uncertain significance Single submitter
- CRYM p.Arg3Leu Conflicting Single submitter
- CRYM p.Arg83Cys Uncertain significance Single submitter
- CRYM p.Asp238Tyr Uncertain significance Single submitter
- CRYM p.Glu157Lys Uncertain significance Single submitter
-
CRYM p.Glu175Val
Conflicting
Single submitter
autosomal dominant nonsyndromic hearing loss 40
- CRYM p.Gly183Glu Uncertain significance Single submitter
- CRYM p.Gly214Val Uncertain significance Single submitter
- CRYM p.Gly278Glu Uncertain significance Single submitter
- CRYM p.Gly84Cys Uncertain significance Single submitter
- CRYM p.Ile115Val Conflicting Single submitter
- CRYM p.Lys256Arg Uncertain significance Single submitter
- CRYM p.Lys54Asn Uncertain significance Single submitter
- CRYM p.Pro281Ser Uncertain significance Single submitter
- CRYM p.Ser160Phe Uncertain significance Single submitter
- CRYM p.Ser190Leu Uncertain significance Single submitter
- CRYM p.Thr287Ala Uncertain significance Single submitter
- CRYM p.Val146Gly Uncertain significance Single submitter
- CRYM p.Val89Asp Uncertain significance Single submitter
All CRYM variants
Conflicting classifications of pathogenicity 9
- p.Ala254Val Single submitter autosomal dominant nonsyndromic hearing loss 40 ⚠
- p.Arg186Gln Single submitter ⚠
- p.Arg3Leu Single submitter ⚠
- p.Gln158= Single submitter
- p.Glu175Leu Single submitter
- p.Glu175Ter Single submitter
- p.Glu175Val Single submitter autosomal dominant nonsyndromic hearing loss 40 ⚠
- p.Ile115Val Single submitter ⚠
- p.Ile306Val Single submitter ⚠
Benign 28
- c.171-118C>T Multiple submitters
- c.171-99G>A Multiple submitters
- c.325-12T>C Multiple submitters autosomal dominant nonsyndromic hearing loss 40
- c.325-162G>T Multiple submitters
- c.387+154G>A Multiple submitters
- c.489+14T>G Multiple submitters
- c.489+20T>G Multiple submitters
- c.489+38G>C Multiple submitters
- c.490-12C>T Multiple submitters
- c.490-86C>T Multiple submitters
- c.490-9C>T Multiple submitters
- c.795+169C>T Multiple submitters
- c.795+266G>A Multiple submitters
- c.795+72T>C Multiple submitters
- c.880+210A>G Multiple submitters
- c.880+264C>T Multiple submitters
- c.881-115T>G Multiple submitters
- c.-54G>C Multiple submitters
- p.Thr288= Multiple submitters autosomal dominant nonsyndromic hearing loss 40
- p.Tyr247= Multiple submitters autosomal dominant nonsyndromic hearing loss 40
- c.171-229T>C Single submitter
- c.324+101G>C Single submitter
- c.325-263C>G Single submitter
- c.388-253T>C Single submitter
- c.489+337A>G Single submitter
- c.673+241C>T Single submitter
- c.674-42G>C Single submitter
- c.796-126dup Single submitter
Benign/Likely benign 2
- p.Glu274Gln Multiple submitters ⚠
- p.Phe269= Multiple submitters
Likely benign 39
- c.*113A>G Multiple submitters
- p.Ala254= Multiple submitters
- p.Pro25= Multiple submitters
- p.Val185= Multiple submitters
- c.170+16C>A Single submitter
- c.170+28C>G Single submitter
- c.170+46G>A Single submitter
- c.170+7G>T Single submitter
- c.171-19G>A Single submitter
- c.325-10T>G Single submitter
- c.325-17C>G Single submitter
- c.325-19G>C Single submitter
- c.387+8G>T Single submitter
- c.388-11C>A Single submitter
- c.388-52C>G Single submitter
- c.489+9A>G Single submitter
- c.490-10C>T Single submitter
- c.673+54G>C Single submitter
- c.674-7C>T Single submitter
- c.880+18C>G Single submitter
- c.880+38C>T Single submitter
- c.881-30A>G Single submitter
- c.-85-4A>G Single submitter
- p.Ala148= Single submitter
- p.Ala221Val Single submitter ⚠
- p.Ala244= Single submitter
- p.Ala266= Single submitter
- p.Ala64= Single submitter
- p.Gln93= Single submitter
- p.Leu76= Single submitter
- p.Pro45= Single submitter
- p.Ser160= Single submitter
- p.Ser66= Single submitter
- p.Thr120= Single submitter
- p.Thr48= Single submitter
- p.Thr53Ala Single submitter
- p.Tyr65= Single submitter
- p.Val289= Single submitter
- p.Ter315= No assertion criteria CRYM-related disorder
Uncertain significance 59
- p.Ala178Glu Multiple submitters ⚠
- p.Ala303Thr Multiple submitters autosomal dominant nonsyndromic hearing loss 40 ⚠
- p.Glu172Gly Multiple submitters ⚠
- p.Ile141Val Multiple submitters autosomal dominant nonsyndromic hearing loss 40 ⚠
- p.Leu72Val Multiple submitters ⚠
- p.Met295Ile Multiple submitters ⚠
- p.Thr95Ser Multiple submitters ⚠
- p.Val4Leu Multiple submitters autosomal dominant nonsyndromic hearing loss 40 ⚠
- c.325-3A>C Single submitter
- c.387+4A>G Single submitter
- c.490-6A>G Single submitter
- c.795+6G>T Single submitter
- p.Ala108Thr Single submitter ⚠
- p.Ala108Val Single submitter ⚠
- p.Ala10Gly Single submitter autosomal dominant nonsyndromic hearing loss 40 ⚠
- p.Ala194Thr Single submitter ⚠
- p.Arg18Cys Single submitter ⚠
- p.Arg56Ser Single submitter ⚠
- p.Arg83Cys Single submitter ⚠
- p.Arg83Gly Single submitter ⚠
- p.Asp238Tyr Single submitter ⚠
- p.Cys284Ter Single submitter
- p.Gln44Arg Single submitter ⚠
- p.Glu157Lys Single submitter ⚠
- p.Glu184Lys Single submitter ⚠
- p.Glu209Gln Single submitter ⚠
- p.Gly183Arg Single submitter ⚠
- p.Gly183Glu Single submitter ⚠
- p.Gly214Val Single submitter ⚠
- p.Gly227Ter Single submitter
- p.Gly278Glu Single submitter ⚠
- p.Gly84Asp Single submitter autosomal dominant nonsyndromic hearing loss 40 ⚠
- p.Gly84Cys Single submitter ⚠
- p.Gly84Ser Single submitter ⚠
- p.Ile211Ser Single submitter ⚠
- p.Leu17Pro Single submitter ⚠
- p.Lys132Asn Single submitter ⚠
- p.Lys162Arg Single submitter ⚠
- p.Lys256Arg Single submitter ⚠
- p.Lys54Asn Single submitter ⚠
- p.Pro281Ser Single submitter ⚠
- p.Ser160Phe Single submitter ⚠
- p.Ser190Leu Single submitter ⚠
- p.Ter315Gln Single submitter autosomal dominant nonsyndromic hearing loss 40
- p.Thr105Ile Single submitter ⚠
- p.Thr203Ile Single submitter ⚠
- p.Thr287Ala Single submitter ⚠
- p.Thr48Pro Single submitter ⚠
- p.Thr86Asn Single submitter ⚠
- p.Trp167Ter Single submitter
- p.Val146Gly Single submitter ⚠
- p.Val181Leu Single submitter ⚠
- p.Val185Ile Single submitter ⚠
- p.Val248Met Single submitter ⚠
- p.Val279Leu Single submitter ⚠
- p.Val297Ala Single submitter ⚠
- p.Val46Leu Single submitter ⚠
- p.Val89Asp Single submitter ⚠
- p.Asp260His No assertion criteria CRYM-related disorder ⚠