CSF3 — 25 ClinVar variants
All ClinVar germline CSF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
6 Benign · 19 Uncertain significance
Full CSF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSF3 p.Ala23Thr Uncertain significance Single submitter
- CSF3 p.Ala59Thr Uncertain significance Single submitter
- CSF3 p.Ala5Val Uncertain significance Single submitter
- CSF3 p.Glu123Val Uncertain significance Single submitter
- CSF3 p.Leu133Val Uncertain significance Single submitter
- CSF3 p.Leu160Pro Uncertain significance Single submitter
- CSF3 p.Met151Leu Uncertain significance Single submitter
- CSF3 p.Phe113Cys Uncertain significance Single submitter
- CSF3 p.Pro9Leu Uncertain significance Single submitter
- CSF3 p.Ser110Gly Uncertain significance Single submitter
- CSF3 p.Ser22Gly Uncertain significance Single submitter
- CSF3 p.Ser93Gly Uncertain significance Single submitter
- CSF3 p.Thr6Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CSF3 p.Leu154Met Benign Multiple submitters
- CSF3 p.His73Gln Uncertain significance Single submitter
- CSF3 p.Leu24Phe Uncertain significance Single submitter
- CSF3 p.Pro204Leu Uncertain significance Single submitter
- CSF3 p.Thr135Ile Uncertain significance Single submitter
- CSF3 p.Thr31Asn Uncertain significance Single submitter
- CSF3 p.Val197Ile Uncertain significance Single submitter
All CSF3 variants
Benign 6
- p.Ala171Thr Multiple submitters
- p.Leu154Met Multiple submitters ⚠
- p.Pro168= Multiple submitters
- c.451-8C>G Single submitter
- p.Gly56= Single submitter
- p.Phe170= Single submitter
Uncertain significance 19
- p.Ala23Thr Single submitter ⚠
- p.Ala59Thr Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Glu123Val Single submitter ⚠
- p.His73Gln Single submitter ⚠
- p.Leu133Val Single submitter ⚠
- p.Leu160Pro Single submitter ⚠
- p.Leu24Phe Single submitter ⚠
- p.Met151Leu Single submitter ⚠
- p.Phe113Cys Single submitter ⚠
- p.Pro204Leu Single submitter ⚠
- p.Pro9Leu Single submitter ⚠
- p.Ser110Gly Single submitter ⚠
- p.Ser22Gly Single submitter ⚠
- p.Ser93Gly Single submitter ⚠
- p.Thr135Ile Single submitter ⚠
- p.Thr31Asn Single submitter ⚠
- p.Thr6Ile Single submitter ⚠
- p.Val197Ile Single submitter ⚠