CSGALNACT2 — 79 ClinVar variants
All ClinVar germline CSGALNACT2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
4 Likely benign · 75 Uncertain significance
Full CSGALNACT2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSGALNACT2 p.Ala186Val Uncertain significance Single submitter
- CSGALNACT2 p.Ala533Thr Uncertain significance Single submitter
- CSGALNACT2 p.Arg165Cys Uncertain significance Single submitter
- CSGALNACT2 p.Arg227Lys Uncertain significance Single submitter
- CSGALNACT2 p.Arg252His Uncertain significance Single submitter
- CSGALNACT2 p.Arg381Gln Uncertain significance Single submitter
- CSGALNACT2 p.Arg428Gln Uncertain significance Single submitter
- CSGALNACT2 p.Arg464Gln Uncertain significance Single submitter
- CSGALNACT2 p.Arg475Trp Uncertain significance Single submitter
- CSGALNACT2 p.Arg77His Uncertain significance Single submitter
- CSGALNACT2 p.Arg94Gln Uncertain significance Single submitter
- CSGALNACT2 p.Asn193His Uncertain significance Single submitter
- CSGALNACT2 p.Asn330Asp Uncertain significance Single submitter
- CSGALNACT2 p.Asn350Thr Uncertain significance Single submitter
- CSGALNACT2 p.Asn537Asp Uncertain significance Single submitter
- CSGALNACT2 p.Asp228Ala Uncertain significance Single submitter
- CSGALNACT2 p.Asp369Gly Uncertain significance Single submitter
- CSGALNACT2 p.Gln416Arg Uncertain significance Single submitter
- CSGALNACT2 p.Glu328Lys Uncertain significance Single submitter
- CSGALNACT2 p.Glu493Lys Uncertain significance Single submitter
- CSGALNACT2 p.Gly221Asp Uncertain significance Single submitter
- CSGALNACT2 p.Gly542Asp Uncertain significance Single submitter
- CSGALNACT2 p.His468Arg Uncertain significance Single submitter
- CSGALNACT2 p.His9Asp Uncertain significance Single submitter
- CSGALNACT2 p.Ile265Phe Uncertain significance Single submitter
- CSGALNACT2 p.Ile370Val Uncertain significance Single submitter
- CSGALNACT2 p.Ile403Val Uncertain significance Single submitter
- CSGALNACT2 p.Ile503Thr Uncertain significance Single submitter
- CSGALNACT2 p.Leu44Val Uncertain significance Single submitter
- CSGALNACT2 p.Leu8Val Uncertain significance Single submitter
- CSGALNACT2 p.Lys130Arg Uncertain significance Single submitter
- CSGALNACT2 p.Lys301Glu Uncertain significance Single submitter
- CSGALNACT2 p.Met264Arg Uncertain significance Single submitter
- CSGALNACT2 p.Met289Thr Uncertain significance Single submitter
- CSGALNACT2 p.Pro140Ser Uncertain significance Single submitter
- CSGALNACT2 p.Ser320Thr Uncertain significance Single submitter
- CSGALNACT2 p.Ser329Phe Uncertain significance Single submitter
- CSGALNACT2 p.Ser74Ile Uncertain significance Single submitter
- CSGALNACT2 p.Trp14Cys Uncertain significance Single submitter
- CSGALNACT2 p.Trp485Cys Uncertain significance Single submitter
- CSGALNACT2 p.Tyr371Cys Uncertain significance Single submitter
- CSGALNACT2 p.Tyr56His Uncertain significance Single submitter
- CSGALNACT2 p.Val47Gly Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- CSGALNACT2 p.Ala35Thr Uncertain significance Single submitter
- CSGALNACT2 p.Arg11Gln Uncertain significance Single submitter
- CSGALNACT2 p.Arg11Trp Uncertain significance Single submitter
- CSGALNACT2 p.Arg165His Uncertain significance Single submitter
- CSGALNACT2 p.Arg3Lys Uncertain significance Single submitter
- CSGALNACT2 p.Arg489Cys Uncertain significance Single submitter
- CSGALNACT2 p.Arg500His Uncertain significance Single submitter
- CSGALNACT2 p.Arg77Cys Uncertain significance Single submitter
- CSGALNACT2 p.Arg94Pro Uncertain significance Single submitter
- CSGALNACT2 p.Asn400Ser Uncertain significance Single submitter
- CSGALNACT2 p.Asp228Glu Uncertain significance Single submitter
- CSGALNACT2 p.Cys34Tyr Uncertain significance Single submitter
- CSGALNACT2 p.Glu203Gln Uncertain significance Single submitter
- CSGALNACT2 p.Glu204Ala Uncertain significance Single submitter
- CSGALNACT2 p.Ile184Met Uncertain significance Single submitter
- CSGALNACT2 p.Ile184Thr Uncertain significance Single submitter
- CSGALNACT2 p.Ile265Thr Uncertain significance Single submitter
- CSGALNACT2 p.Leu188Phe Uncertain significance Single submitter
- CSGALNACT2 p.Leu235Val Uncertain significance Single submitter
- CSGALNACT2 p.Leu8Ile Uncertain significance Single submitter
- CSGALNACT2 p.Lys319Met Uncertain significance Single submitter
- CSGALNACT2 p.Met258Thr Uncertain significance Single submitter
- CSGALNACT2 p.Phe251Leu Uncertain significance Single submitter
- CSGALNACT2 p.Pro194Ser Uncertain significance Single submitter
- CSGALNACT2 p.Ser324Pro Uncertain significance Single submitter
- CSGALNACT2 p.Ser379Arg Uncertain significance Single submitter
- CSGALNACT2 p.Ser379Gly Uncertain significance Single submitter
- CSGALNACT2 p.Ser95Pro Uncertain significance Single submitter
- CSGALNACT2 p.Tyr534Cys Uncertain significance Single submitter
- CSGALNACT2 p.Val190Asp Uncertain significance Single submitter
- CSGALNACT2 p.Val419Leu Uncertain significance Single submitter
- CSGALNACT2 p.Val419Phe Uncertain significance Single submitter
All CSGALNACT2 variants
Likely benign 4
- p.Ile271Val Single submitter
- p.Ser111Gly Single submitter
- p.Thr243Met Single submitter
- p.Val219Ile Single submitter
Uncertain significance 75
- p.Ala186Val Single submitter ⚠
- p.Ala35Thr Single submitter ⚠
- p.Ala533Thr Single submitter ⚠
- p.Arg11Gln Single submitter ⚠
- p.Arg11Trp Single submitter ⚠
- p.Arg165Cys Single submitter ⚠
- p.Arg165His Single submitter ⚠
- p.Arg227Lys Single submitter ⚠
- p.Arg252His Single submitter ⚠
- p.Arg381Gln Single submitter ⚠
- p.Arg3Lys Single submitter ⚠
- p.Arg428Gln Single submitter ⚠
- p.Arg464Gln Single submitter ⚠
- p.Arg475Trp Single submitter ⚠
- p.Arg489Cys Single submitter ⚠
- p.Arg500His Single submitter ⚠
- p.Arg77Cys Single submitter ⚠
- p.Arg77His Single submitter ⚠
- p.Arg94Gln Single submitter ⚠
- p.Arg94Pro Single submitter ⚠
- p.Asn193His Single submitter ⚠
- p.Asn330Asp Single submitter ⚠
- p.Asn350Thr Single submitter ⚠
- p.Asn400Ser Single submitter ⚠
- p.Asn537Asp Single submitter ⚠
- p.Asp228Ala Single submitter ⚠
- p.Asp228Glu Single submitter ⚠
- p.Asp369Gly Single submitter ⚠
- p.Cys34Tyr Single submitter ⚠
- p.Gln416Arg Single submitter ⚠
- p.Glu203Gln Single submitter ⚠
- p.Glu204Ala Single submitter ⚠
- p.Glu328Lys Single submitter ⚠
- p.Glu493Lys Single submitter ⚠
- p.Gly221Asp Single submitter ⚠
- p.Gly542Asp Single submitter ⚠
- p.His468Arg Single submitter ⚠
- p.His9Asp Single submitter ⚠
- p.Ile184Met Single submitter ⚠
- p.Ile184Thr Single submitter ⚠
- p.Ile265Phe Single submitter ⚠
- p.Ile265Thr Single submitter ⚠
- p.Ile370Val Single submitter ⚠
- p.Ile403Val Single submitter ⚠
- p.Ile503Thr Single submitter ⚠
- p.Leu188Phe Single submitter ⚠
- p.Leu235Val Single submitter ⚠
- p.Leu44Val Single submitter ⚠
- p.Leu8Ile Single submitter ⚠
- p.Leu8Val Single submitter ⚠
- p.Lys130Arg Single submitter ⚠
- p.Lys301Glu Single submitter ⚠
- p.Lys319Met Single submitter ⚠
- p.Met258Thr Single submitter ⚠
- p.Met264Arg Single submitter ⚠
- p.Met289Thr Single submitter ⚠
- p.Phe251Leu Single submitter ⚠
- p.Pro140Ser Single submitter ⚠
- p.Pro194Ser Single submitter ⚠
- p.Ser320Thr Single submitter ⚠
- p.Ser324Pro Single submitter ⚠
- p.Ser329Phe Single submitter ⚠
- p.Ser379Arg Single submitter ⚠
- p.Ser379Gly Single submitter ⚠
- p.Ser74Ile Single submitter ⚠
- p.Ser95Pro Single submitter ⚠
- p.Trp14Cys Single submitter ⚠
- p.Trp485Cys Single submitter ⚠
- p.Tyr371Cys Single submitter ⚠
- p.Tyr534Cys Single submitter ⚠
- p.Tyr56His Single submitter ⚠
- p.Val190Asp Single submitter ⚠
- p.Val419Leu Single submitter ⚠
- p.Val419Phe Single submitter ⚠
- p.Val47Gly Single submitter ⚠