CSK — 32 ClinVar variants
All ClinVar germline CSK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
2 Benign · 2 Likely benign · 28 Uncertain significance
Full CSK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSK p.Arg94Gln Uncertain significance Single submitter
- CSK p.Glu417Asp Uncertain significance Single submitter
- CSK p.Ile264Val Uncertain significance Single submitter
- CSK p.Met150Val Uncertain significance Single submitter
- CSK p.Met192Thr Uncertain significance Single submitter
- CSK p.Thr200Ile Uncertain significance Single submitter
- CSK p.Thr445Ala Uncertain significance Single submitter
- CSK p.Tyr403Cys Uncertain significance Single submitter
- CSK p.Val41Ile Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- CSK p.Ala407Thr Uncertain significance Single submitter
- CSK p.Arg56Cys Uncertain significance Single submitter
- CSK p.Arg56His Uncertain significance Single submitter
- CSK p.Asn46Lys Uncertain significance Single submitter
- CSK p.Asn63Ser Uncertain significance Single submitter
- CSK p.Asp123Asn Uncertain significance Single submitter
- CSK p.Cys223Trp Uncertain significance Single submitter
- CSK p.Gly22Ser Uncertain significance Single submitter
- CSK p.Gly261Arg Uncertain significance Single submitter
- CSK p.Gly288Arg Uncertain significance Single submitter
- CSK p.Gly410Ser Uncertain significance Single submitter
- CSK p.Ile224Val Uncertain significance Single submitter
- CSK p.Lys218Arg Uncertain significance Single submitter
- CSK p.Pro99Leu Uncertain significance Single submitter
- CSK p.Thr345Met Uncertain significance Single submitter
- CSK p.Val221Ile Uncertain significance Single submitter
- CSK p.Val327Met Uncertain significance Single submitter
- CSK p.Val399Leu Uncertain significance Single submitter
- CSK p.Val65Ile Uncertain significance Single submitter
All CSK variants
Benign 2
- p.Gly287Asp Multiple submitters
- p.Ala428Thr Single submitter
Likely benign 2
- p.Thr88= Single submitter
- p.Tyr97Cys Single submitter
Uncertain significance 28
- p.Ala407Thr Single submitter ⚠
- p.Arg56Cys Single submitter ⚠
- p.Arg56His Single submitter ⚠
- p.Arg94Gln Single submitter ⚠
- p.Asn46Lys Single submitter ⚠
- p.Asn63Ser Single submitter ⚠
- p.Asp123Asn Single submitter ⚠
- p.Cys223Trp Single submitter ⚠
- p.Glu417Asp Single submitter ⚠
- p.Gly22Ser Single submitter ⚠
- p.Gly261Arg Single submitter ⚠
- p.Gly288Arg Single submitter ⚠
- p.Gly410Ser Single submitter ⚠
- p.Ile224Val Single submitter ⚠
- p.Ile264Val Single submitter ⚠
- p.Lys218Arg Single submitter ⚠
- p.Met150Val Single submitter ⚠
- p.Met192Thr Single submitter ⚠
- p.Pro99Leu Single submitter ⚠
- p.Thr200Ile Single submitter ⚠
- p.Thr345Met Single submitter ⚠
- p.Thr445Ala Single submitter ⚠
- p.Tyr403Cys Single submitter ⚠
- p.Val221Ile Single submitter ⚠
- p.Val327Met Single submitter ⚠
- p.Val399Leu Single submitter ⚠
- p.Val41Ile Single submitter ⚠
- p.Val65Ile Single submitter ⚠