CSNK1A1 — 6 ClinVar variants
All ClinVar germline CSNK1A1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 4 flagged for review →
6 Uncertain significance
Full CSNK1A1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 4
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All CSNK1A1 variants
Uncertain significance 6
- c.456+2492dup Single submitter
- p.Gln320Leu Single submitter ⚠
- p.Gly316Asp Single submitter ⚠
- p.Ser61fs Single submitter
- p.Thr321Ile Single submitter ⚠
- p.Thr330Ser Single submitter ⚠