CSNK1G2 — 41 ClinVar variants
All ClinVar germline CSNK1G2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
4 Likely benign · 37 Uncertain significance
Full CSNK1G2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSNK1G2 p.Ala237Ser Uncertain significance Single submitter
- CSNK1G2 p.Ala273Thr Uncertain significance Single submitter
- CSNK1G2 p.Ala373Val Uncertain significance Single submitter
- CSNK1G2 p.Arg135Gly Uncertain significance Single submitter
- CSNK1G2 p.Arg152Leu Uncertain significance Single submitter
- CSNK1G2 p.Arg164Gln Uncertain significance Single submitter
- CSNK1G2 p.Arg175Cys Uncertain significance Single submitter
- CSNK1G2 p.Arg232Cys Uncertain significance Single submitter
- CSNK1G2 p.Arg247Cys Uncertain significance Single submitter
- CSNK1G2 p.Arg413Gln Uncertain significance Single submitter
- CSNK1G2 p.Asp317His Uncertain significance Single submitter
- CSNK1G2 p.Gln229Pro Uncertain significance Single submitter
- CSNK1G2 p.Gln412Arg Uncertain significance Single submitter
- CSNK1G2 p.Glu169Lys Uncertain significance Single submitter
- CSNK1G2 p.Glu89Gln Uncertain significance Single submitter
- CSNK1G2 p.Gly190Arg Uncertain significance Single submitter
- CSNK1G2 p.Gly24Ser Uncertain significance Single submitter
- CSNK1G2 p.Gly369Trp Uncertain significance Single submitter
- CSNK1G2 p.His182Gln Uncertain significance Single submitter
- CSNK1G2 p.Leu351Phe Uncertain significance Single submitter
- CSNK1G2 p.Lys310Arg Uncertain significance Single submitter
- CSNK1G2 p.Pro335Ala Uncertain significance Single submitter
- CSNK1G2 p.Pro346Thr Uncertain significance Single submitter
- CSNK1G2 p.Pro78Leu Uncertain significance Single submitter
- CSNK1G2 p.Thr12Met Uncertain significance Single submitter
- CSNK1G2 p.Thr274Met Uncertain significance Single submitter
- CSNK1G2 p.Thr367Ile Uncertain significance Single submitter
- CSNK1G2 p.Thr397Ser Uncertain significance Single submitter
- CSNK1G2 p.Val102Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- CSNK1G2 p.Ala288Val Uncertain significance Single submitter
- CSNK1G2 p.Arg272Cys Uncertain significance Single submitter
- CSNK1G2 p.Cys111Tyr Uncertain significance Single submitter
- CSNK1G2 p.His182Asp Uncertain significance Single submitter
- CSNK1G2 p.Lys202Gln Uncertain significance Single submitter
- CSNK1G2 p.Phe300Leu Uncertain significance Single submitter
- CSNK1G2 p.Ser249Asn Uncertain significance Single submitter
- CSNK1G2 p.Ser33Leu Uncertain significance Single submitter
All CSNK1G2 variants
Likely benign 4
- p.Gly29Ser Single submitter
- p.Thr259= Single submitter
- p.Thr343Ser Single submitter
- p.Val341= Single submitter
Uncertain significance 37
- p.Ala237Ser Single submitter ⚠
- p.Ala273Thr Single submitter ⚠
- p.Ala288Val Single submitter ⚠
- p.Ala373Val Single submitter ⚠
- p.Arg135Gly Single submitter ⚠
- p.Arg152Leu Single submitter ⚠
- p.Arg164Gln Single submitter ⚠
- p.Arg175Cys Single submitter ⚠
- p.Arg232Cys Single submitter ⚠
- p.Arg247Cys Single submitter ⚠
- p.Arg272Cys Single submitter ⚠
- p.Arg413Gln Single submitter ⚠
- p.Asp317His Single submitter ⚠
- p.Cys111Tyr Single submitter ⚠
- p.Gln229Pro Single submitter ⚠
- p.Gln412Arg Single submitter ⚠
- p.Glu169Lys Single submitter ⚠
- p.Glu89Gln Single submitter ⚠
- p.Gly190Arg Single submitter ⚠
- p.Gly24Ser Single submitter ⚠
- p.Gly369Trp Single submitter ⚠
- p.His182Asp Single submitter ⚠
- p.His182Gln Single submitter ⚠
- p.Leu351Phe Single submitter ⚠
- p.Lys202Gln Single submitter ⚠
- p.Lys310Arg Single submitter ⚠
- p.Phe300Leu Single submitter ⚠
- p.Pro335Ala Single submitter ⚠
- p.Pro346Thr Single submitter ⚠
- p.Pro78Leu Single submitter ⚠
- p.Ser249Asn Single submitter ⚠
- p.Ser33Leu Single submitter ⚠
- p.Thr12Met Single submitter ⚠
- p.Thr274Met Single submitter ⚠
- p.Thr367Ile Single submitter ⚠
- p.Thr397Ser Single submitter ⚠
- p.Val102Ile Single submitter ⚠