CSNK1G3 — 35 ClinVar variants
All ClinVar germline CSNK1G3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
1 Benign · 3 Likely benign · 31 Uncertain significance
Full CSNK1G3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSNK1G3 p.Ala337Gly Uncertain significance Single submitter
- CSNK1G3 p.Ala350Gly Uncertain significance Single submitter
- CSNK1G3 p.Ala376Thr Uncertain significance Single submitter
- CSNK1G3 p.Ala411Thr Uncertain significance Single submitter
- CSNK1G3 p.Arg149His Uncertain significance Single submitter
- CSNK1G3 p.Asn25Lys Uncertain significance Single submitter
- CSNK1G3 p.Asp314Asn Uncertain significance Single submitter
- CSNK1G3 p.Cys442Arg Uncertain significance Single submitter
- CSNK1G3 p.Ile452Val Uncertain significance Single submitter
- CSNK1G3 p.Lys361Arg Uncertain significance Single submitter
- CSNK1G3 p.Lys6Arg Uncertain significance Single submitter
- CSNK1G3 p.Pro81Ala Uncertain significance Single submitter
- CSNK1G3 p.Ser364Leu Uncertain significance Single submitter
- CSNK1G3 p.Val102Ala Uncertain significance Single submitter
- CSNK1G3 p.Val396Phe Uncertain significance Single submitter
- CSNK1G3 p.Val45Ala Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CSNK1G3 p.Arg269Trp Uncertain significance Single submitter
- CSNK1G3 p.Arg315Gln Uncertain significance Single submitter
- CSNK1G3 p.Arg454Cys Uncertain significance Single submitter
- CSNK1G3 p.Asn112Ser Uncertain significance Single submitter
- CSNK1G3 p.Asp194Glu Uncertain significance Single submitter
- CSNK1G3 p.Asp303His Uncertain significance Single submitter
- CSNK1G3 p.Met240Ile Uncertain significance Single submitter
- CSNK1G3 p.Pro195Leu Uncertain significance Single submitter
- CSNK1G3 p.Ser22Leu Uncertain significance Single submitter
- CSNK1G3 p.Ser33Leu Uncertain significance Single submitter
- CSNK1G3 p.Ser399Phe Uncertain significance Single submitter
- CSNK1G3 p.Thr133Ile Uncertain significance Single submitter
- CSNK1G3 p.Thr65Ser Uncertain significance Single submitter
- CSNK1G3 p.Tyr318Cys Uncertain significance Single submitter
- CSNK1G3 p.Val36Leu Uncertain significance Single submitter
All CSNK1G3 variants
Benign 1
- c.1186-6A>G No assertion criteria CSNK1G3-related disorder
Likely benign 3
- c.1186-4A>G No assertion criteria CSNK1G3-related disorder
- p.Ser393= No assertion criteria CSNK1G3-related disorder
- p.Thr451= No assertion criteria CSNK1G3-related disorder
Uncertain significance 31
- p.Ala337Gly Single submitter ⚠
- p.Ala350Gly Single submitter ⚠
- p.Ala376Thr Single submitter ⚠
- p.Ala411Thr Single submitter ⚠
- p.Arg149His Single submitter ⚠
- p.Arg269Trp Single submitter ⚠
- p.Arg315Gln Single submitter ⚠
- p.Arg454Cys Single submitter ⚠
- p.Asn112Ser Single submitter ⚠
- p.Asn25Lys Single submitter ⚠
- p.Asp194Glu Single submitter ⚠
- p.Asp303His Single submitter ⚠
- p.Asp314Asn Single submitter ⚠
- p.Cys442Arg Single submitter ⚠
- p.Ile452Val Single submitter ⚠
- p.Lys361Arg Single submitter ⚠
- p.Lys6Arg Single submitter ⚠
- p.Met240Ile Single submitter ⚠
- p.Pro195Leu Single submitter ⚠
- p.Pro81Ala Single submitter ⚠
- p.Ser22Leu Single submitter ⚠
- p.Ser33Leu Single submitter ⚠
- p.Ser364Leu Single submitter ⚠
- p.Ser399Phe Single submitter ⚠
- p.Thr133Ile Single submitter ⚠
- p.Thr65Ser Single submitter ⚠
- p.Tyr318Cys Single submitter ⚠
- p.Val102Ala Single submitter ⚠
- p.Val36Leu Single submitter ⚠
- p.Val396Phe Single submitter ⚠
- p.Val45Ala Single submitter ⚠