CSNK2A2 — 42 ClinVar variants
All ClinVar germline CSNK2A2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
18 Benign · 24 Uncertain significance
Full CSNK2A2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 10
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSNK2A2 p.Ala57Ser Uncertain significance Single submitter
- CSNK2A2 p.Arg245Ser Uncertain significance Single submitter
- CSNK2A2 p.Glu115Asp Uncertain significance Single submitter
- CSNK2A2 p.His235Arg Uncertain significance Single submitter
- CSNK2A2 p.His269Arg Uncertain significance Single submitter
- CSNK2A2 p.Leu219Trp Uncertain significance Single submitter
- CSNK2A2 p.Met226Thr Uncertain significance Single submitter
- CSNK2A2 p.Phe114Leu Uncertain significance Single submitter
- CSNK2A2 p.Ser295Thr Uncertain significance Single submitter
- CSNK2A2 p.Val205Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- CSNK2A2 p.Ala5Thr Uncertain significance Single submitter
- CSNK2A2 p.Arg229Gln Uncertain significance Single submitter
- CSNK2A2 p.Arg291Gly Uncertain significance Single submitter
- CSNK2A2 p.Arg307Gln Uncertain significance Single submitter
- CSNK2A2 p.Asn271Ser Uncertain significance Single submitter
- CSNK2A2 p.Asp26Asn Uncertain significance Single submitter
- CSNK2A2 p.Ile95Val Uncertain significance Single submitter
- CSNK2A2 p.Phe132Ser Uncertain significance Single submitter
- CSNK2A2 p.Phe132Val Uncertain significance Single submitter
- CSNK2A2 p.Pro296Leu Uncertain significance Single submitter
- CSNK2A2 p.Pro327Ser Uncertain significance Single submitter
- CSNK2A2 p.Val106Met Uncertain significance Single submitter
- CSNK2A2 p.Val74Leu Uncertain significance Single submitter
All CSNK2A2 variants
Benign 18
- c.104+271G>A Multiple submitters
- c.104+50C>T Multiple submitters
- c.369+188A>G Multiple submitters
- c.370-122A>G Multiple submitters
- c.514-60T>C Multiple submitters
- c.727-29T>G Multiple submitters
- c.828-140C>A Multiple submitters
- c.828-58G>A Multiple submitters
- c.977-88C>G Multiple submitters
- c.-37C>T Multiple submitters
- c.216+313T>C Single submitter
- c.319-275C>T Single submitter
- c.514-150G>A Single submitter
- c.514-232A>G Single submitter
- c.726+138G>A Single submitter
- c.828-242G>A Single submitter
- c.976+261C>A Single submitter
- p.Ser195= Single submitter
Uncertain significance 24
- p.Ala57Ser Single submitter ⚠
- p.Ala5Thr Single submitter ⚠
- p.Arg229Gln Single submitter ⚠
- p.Arg245Ser Single submitter ⚠
- p.Arg291Gly Single submitter ⚠
- p.Arg307Gln Single submitter ⚠
- p.Asn271Ser Single submitter ⚠
- p.Asp26Asn Single submitter ⚠
- p.Glu115Asp Single submitter ⚠
- p.His235Arg Single submitter ⚠
- p.His269Arg Single submitter ⚠
- p.Ile95Val Single submitter ⚠
- p.Leu219Trp Single submitter ⚠
- p.Met226Thr Single submitter ⚠
- p.Phe114Leu Single submitter ⚠
- p.Phe132Ser Single submitter ⚠
- p.Phe132Val Single submitter ⚠
- p.Pro296Leu Single submitter ⚠
- p.Pro327Ser Single submitter ⚠
- p.Ser295Thr Single submitter ⚠
- p.Val106Met Single submitter ⚠
- p.Val205Met Single submitter ⚠
- p.Val74Leu Single submitter ⚠
- p.Tyr27Ter No assertion criteria CSNK2A2-related disorder