CSRNP3 — 75 ClinVar variants
All ClinVar germline CSRNP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 71 flagged for review →
2 Benign · 2 Likely benign · 71 Uncertain significance
Full CSRNP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 71
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSRNP3 p.Ala230Thr Uncertain significance Single submitter
- CSRNP3 p.Ala306Thr Uncertain significance Single submitter
- CSRNP3 p.Ala314Val Uncertain significance Single submitter
- CSRNP3 p.Ala326Ser Uncertain significance Single submitter
- CSRNP3 p.Ala333Ser Uncertain significance Single submitter
- CSRNP3 p.Ala417Thr Uncertain significance Single submitter
- CSRNP3 p.Ala426Pro Uncertain significance Single submitter
- CSRNP3 p.Ala487Gly Uncertain significance Single submitter
- CSRNP3 p.Ala565Glu Uncertain significance Single submitter
- CSRNP3 p.Arg265Gln Uncertain significance Single submitter
- CSRNP3 p.Arg281Gln Uncertain significance Single submitter
- CSRNP3 p.Arg457Lys Uncertain significance Single submitter
- CSRNP3 p.Arg482Gln Uncertain significance Single submitter
- CSRNP3 p.Arg523Gly Uncertain significance Single submitter
- CSRNP3 p.Arg97Cys Uncertain significance Single submitter
- CSRNP3 p.Asn165Asp Uncertain significance Single submitter
- CSRNP3 p.Asn431His Uncertain significance Single submitter
- CSRNP3 p.Asn497His Uncertain significance Single submitter
- CSRNP3 p.Asp337Gly Uncertain significance Single submitter
- CSRNP3 p.Asp479His Uncertain significance Single submitter
- CSRNP3 p.Asp550Gly Uncertain significance Single submitter
- CSRNP3 p.Gln284His Uncertain significance Single submitter
- CSRNP3 p.Gln449His Uncertain significance Single submitter
- CSRNP3 p.Glu347Asp Uncertain significance Single submitter
- CSRNP3 p.Glu372Asp Uncertain significance Single submitter
- CSRNP3 p.Glu402Lys Uncertain significance Single submitter
- CSRNP3 p.Glu420Lys Uncertain significance Single submitter
- CSRNP3 p.Glu508Lys Uncertain significance Single submitter
- CSRNP3 p.Glu559Gly Uncertain significance Single submitter
- CSRNP3 p.Gly14Ser Uncertain significance Single submitter
- CSRNP3 p.Gly244Ser Uncertain significance Single submitter
- CSRNP3 p.Gly392Arg Uncertain significance Single submitter
- CSRNP3 p.Gly396Asp Uncertain significance Single submitter
- CSRNP3 p.Gly80Val Uncertain significance Single submitter
- CSRNP3 p.His422Arg Uncertain significance Single submitter
- CSRNP3 p.His522Tyr Uncertain significance Single submitter
- CSRNP3 p.His526Gln Uncertain significance Single submitter
- CSRNP3 p.Ile262Val Uncertain significance Single submitter
- CSRNP3 p.Ile295Val Uncertain significance Single submitter
- CSRNP3 p.Ile319Thr Uncertain significance Single submitter
- CSRNP3 p.Ile319Val Uncertain significance Single submitter
- CSRNP3 p.Leu151Pro Uncertain significance Single submitter
- CSRNP3 p.Phe393Leu Uncertain significance Single submitter
- CSRNP3 p.Pro407Ser Uncertain significance Single submitter
- CSRNP3 p.Pro447Thr Uncertain significance Single submitter
- CSRNP3 p.Pro514Leu Uncertain significance Single submitter
- CSRNP3 p.Pro538Leu Uncertain significance Single submitter
- CSRNP3 p.Ser20Pro Uncertain significance Single submitter
- CSRNP3 p.Ser296Gly Uncertain significance Single submitter
- CSRNP3 p.Ser351Gly Uncertain significance Single submitter
- CSRNP3 p.Ser505Phe Uncertain significance Single submitter
- CSRNP3 p.Ser517Asn Uncertain significance Single submitter
- CSRNP3 p.Ser563Asn Uncertain significance Single submitter
- CSRNP3 p.Ser568Asn Uncertain significance Single submitter
- CSRNP3 p.Thr150Ser Uncertain significance Single submitter
- CSRNP3 p.Thr434Ile Uncertain significance Single submitter
- CSRNP3 p.Thr459Pro Uncertain significance Single submitter
- CSRNP3 p.Val101Met Uncertain significance Single submitter
- CSRNP3 p.Val403Leu Uncertain significance Single submitter
- CSRNP3 p.Val404Phe Uncertain significance Single submitter
- CSRNP3 p.Val409Leu Uncertain significance Single submitter
- CSRNP3 p.Val418Ile Uncertain significance Single submitter
- CSRNP3 p.Val468Ala Uncertain significance Single submitter
- CSRNP3 p.Val579Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CSRNP3 p.Ala188Asp Uncertain significance Single submitter
- CSRNP3 p.Arg102His Uncertain significance Single submitter
- CSRNP3 p.Glu170Ala Uncertain significance Single submitter
- CSRNP3 p.Glu374Ala Uncertain significance Single submitter
- CSRNP3 p.Ile156Thr Uncertain significance Single submitter
- CSRNP3 p.Lys181Gln Uncertain significance Single submitter
- CSRNP3 p.Val409Gly Uncertain significance Single submitter
All CSRNP3 variants
Likely benign 2
- p.Asp388= Single submitter
- p.Val394Met Single submitter
Uncertain significance 71
- p.Ala188Asp Single submitter ⚠
- p.Ala230Thr Single submitter ⚠
- p.Ala306Thr Single submitter ⚠
- p.Ala314Val Single submitter ⚠
- p.Ala326Ser Single submitter ⚠
- p.Ala333Ser Single submitter ⚠
- p.Ala417Thr Single submitter ⚠
- p.Ala426Pro Single submitter ⚠
- p.Ala487Gly Single submitter ⚠
- p.Ala565Glu Single submitter ⚠
- p.Arg102His Single submitter ⚠
- p.Arg265Gln Single submitter ⚠
- p.Arg281Gln Single submitter ⚠
- p.Arg457Lys Single submitter ⚠
- p.Arg482Gln Single submitter ⚠
- p.Arg523Gly Single submitter ⚠
- p.Arg97Cys Single submitter ⚠
- p.Asn165Asp Single submitter ⚠
- p.Asn431His Single submitter ⚠
- p.Asn497His Single submitter ⚠
- p.Asp337Gly Single submitter ⚠
- p.Asp479His Single submitter ⚠
- p.Asp550Gly Single submitter ⚠
- p.Gln284His Single submitter ⚠
- p.Gln449His Single submitter ⚠
- p.Glu170Ala Single submitter ⚠
- p.Glu347Asp Single submitter ⚠
- p.Glu372Asp Single submitter ⚠
- p.Glu374Ala Single submitter ⚠
- p.Glu402Lys Single submitter ⚠
- p.Glu420Lys Single submitter ⚠
- p.Glu508Lys Single submitter ⚠
- p.Glu559Gly Single submitter ⚠
- p.Gly14Ser Single submitter ⚠
- p.Gly244Ser Single submitter ⚠
- p.Gly392Arg Single submitter ⚠
- p.Gly396Asp Single submitter ⚠
- p.Gly80Val Single submitter ⚠
- p.His422Arg Single submitter ⚠
- p.His522Tyr Single submitter ⚠
- p.His526Gln Single submitter ⚠
- p.Ile156Thr Single submitter ⚠
- p.Ile262Val Single submitter ⚠
- p.Ile295Val Single submitter ⚠
- p.Ile319Thr Single submitter ⚠
- p.Ile319Val Single submitter ⚠
- p.Leu151Pro Single submitter ⚠
- p.Lys181Gln Single submitter ⚠
- p.Phe393Leu Single submitter ⚠
- p.Pro407Ser Single submitter ⚠
- p.Pro447Thr Single submitter ⚠
- p.Pro514Leu Single submitter ⚠
- p.Pro538Leu Single submitter ⚠
- p.Ser20Pro Single submitter ⚠
- p.Ser296Gly Single submitter ⚠
- p.Ser351Gly Single submitter ⚠
- p.Ser505Phe Single submitter ⚠
- p.Ser517Asn Single submitter ⚠
- p.Ser563Asn Single submitter ⚠
- p.Ser568Asn Single submitter ⚠
- p.Thr150Ser Single submitter ⚠
- p.Thr434Ile Single submitter ⚠
- p.Thr459Pro Single submitter ⚠
- p.Val101Met Single submitter ⚠
- p.Val403Leu Single submitter ⚠
- p.Val404Phe Single submitter ⚠
- p.Val409Gly Single submitter ⚠
- p.Val409Leu Single submitter ⚠
- p.Val418Ile Single submitter ⚠
- p.Val468Ala Single submitter ⚠
- p.Val579Met Single submitter ⚠