CSRP2 — 17 ClinVar variants
All ClinVar germline CSRP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
17 Uncertain significance
Full CSRP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSRP2 p.Arg84His Uncertain significance Single submitter
- CSRP2 p.Asn81Thr Uncertain significance Single submitter
- CSRP2 p.Cys146Arg Uncertain significance Single submitter
- CSRP2 p.Cys146Tyr Uncertain significance Single submitter
- CSRP2 p.Glu117Asp Uncertain significance Single submitter
- CSRP2 p.Glu130Lys Uncertain significance Single submitter
- CSRP2 p.Gly183Asp Uncertain significance Single submitter
- CSRP2 p.Met82Leu Uncertain significance Single submitter
- CSRP2 p.Tyr166His Uncertain significance Single submitter
- CSRP2 p.Tyr171Cys Uncertain significance Single submitter
- CSRP2 p.Tyr57His Uncertain significance Single submitter
- CSRP2 p.Tyr62Cys Uncertain significance Single submitter
- CSRP2 p.Val17Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CSRP2 variants
Uncertain significance 17
- p.Arg145Gln Single submitter ⚠
- p.Arg84His Single submitter ⚠
- p.Asn81Thr Single submitter ⚠
- p.Cys146Arg Single submitter ⚠
- p.Cys146Tyr Single submitter ⚠
- p.Glu117Asp Single submitter ⚠
- p.Glu130Lys Single submitter ⚠
- p.Glu54Lys Single submitter ⚠
- p.Gly183Asp Single submitter ⚠
- p.Met82Leu Single submitter ⚠
- p.Pro138Leu Single submitter ⚠
- p.Pro92Leu Single submitter ⚠
- p.Tyr166His Single submitter ⚠
- p.Tyr171Cys Single submitter ⚠
- p.Tyr57His Single submitter ⚠
- p.Tyr62Cys Single submitter ⚠
- p.Val17Met Single submitter ⚠