CST11 — 24 ClinVar variants
All ClinVar germline CST11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
3 Likely benign · 21 Uncertain significance
Full CST11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CST11 p.Ala21Val Uncertain significance Single submitter
- CST11 p.Arg66Ser Uncertain significance Single submitter
- CST11 p.Arg69Gln Uncertain significance Single submitter
- CST11 p.Asp138Tyr Uncertain significance Single submitter
- CST11 p.Gln25Lys Uncertain significance Single submitter
- CST11 p.Gln95Arg Uncertain significance Single submitter
- CST11 p.His110Leu Uncertain significance Single submitter
- CST11 p.Met20Ile Uncertain significance Single submitter
- CST11 p.Thr93Asn Uncertain significance Single submitter
- CST11 p.Val34Ile Uncertain significance Single submitter
- CST11 p.Val73Ala Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CST11 p.Ala21Pro Uncertain significance Single submitter
- CST11 p.Ala3Gly Uncertain significance Single submitter
- CST11 p.Asn114Asp Uncertain significance Single submitter
- CST11 p.Asp53Asn Uncertain significance Single submitter
- CST11 p.Ile67Phe Uncertain significance Single submitter
- CST11 p.Lys111Glu Uncertain significance Single submitter
- CST11 p.Phe116Leu Uncertain significance Single submitter
- CST11 p.Phe125Leu Uncertain significance Single submitter
- CST11 p.Thr93Ala Uncertain significance Single submitter
- CST11 p.Val37Ala Uncertain significance Single submitter
All CST11 variants
Likely benign 3
- p.Arg75Lys Single submitter
- p.His110Tyr Single submitter
- p.Trp91Arg Single submitter
Uncertain significance 21
- p.Ala21Pro Single submitter ⚠
- p.Ala21Val Single submitter ⚠
- p.Ala3Gly Single submitter ⚠
- p.Arg66Ser Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Asn114Asp Single submitter ⚠
- p.Asp138Tyr Single submitter ⚠
- p.Asp53Asn Single submitter ⚠
- p.Gln25Lys Single submitter ⚠
- p.Gln95Arg Single submitter ⚠
- p.His110Leu Single submitter ⚠
- p.Ile67Phe Single submitter ⚠
- p.Lys111Glu Single submitter ⚠
- p.Met20Ile Single submitter ⚠
- p.Phe116Leu Single submitter ⚠
- p.Phe125Leu Single submitter ⚠
- p.Thr93Ala Single submitter ⚠
- p.Thr93Asn Single submitter ⚠
- p.Val34Ile Single submitter ⚠
- p.Val37Ala Single submitter ⚠
- p.Val73Ala Single submitter ⚠