CST2 — 48 ClinVar variants
All ClinVar germline CST2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Benign · 6 Likely benign · 41 Uncertain significance
Full CST2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CST2 p.Arg28Lys Uncertain significance Single submitter
- CST2 p.Asp129Asn Uncertain significance Single submitter
- CST2 p.Cys118Ser Uncertain significance Single submitter
- CST2 p.Cys94Tyr Uncertain significance Single submitter
- CST2 p.Glu124Lys Uncertain significance Single submitter
- CST2 p.Glu31Lys Uncertain significance Single submitter
- CST2 p.His49Leu Uncertain significance Single submitter
- CST2 p.Lys57Arg Uncertain significance Single submitter
- CST2 p.Met131Ile Uncertain significance Single submitter
- CST2 p.Ser22Arg Uncertain significance Single submitter
- CST2 p.Thr59Ser Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- CST2 p.Arg69Trp Benign Multiple submitters
- CST2 p.Ala16Val Uncertain significance Single submitter
- CST2 p.Ala2Val Uncertain significance Single submitter
- CST2 p.Ala58Val Uncertain significance Single submitter
- CST2 p.Ala73Val Uncertain significance Single submitter
- CST2 p.Arg130Gly Uncertain significance Single submitter
- CST2 p.Arg43Trp Likely benign Single submitter
- CST2 p.Arg46His Uncertain significance Single submitter
- CST2 p.Arg72Gln Uncertain significance Single submitter
- CST2 p.Asp38Glu Uncertain significance Single submitter
- CST2 p.Asp38Gly Uncertain significance Single submitter
- CST2 p.Asp61Glu Uncertain significance Single submitter
- CST2 p.Asp86Asn Uncertain significance Single submitter
- CST2 p.Gln109Pro Uncertain significance Single submitter
- CST2 p.Gln113Arg Uncertain significance Single submitter
- CST2 p.Gln121Glu Uncertain significance Single submitter
- CST2 p.Gln15His Uncertain significance Single submitter
- CST2 p.Gln45Lys Uncertain significance Single submitter
- CST2 p.Glu26Lys Uncertain significance Single submitter
- CST2 p.Glu54Lys Uncertain significance Single submitter
- CST2 p.Gly33Ser Uncertain significance Single submitter
- CST2 p.Ile77Thr Likely benign Single submitter
- CST2 p.Leu19Val Uncertain significance Single submitter
- CST2 p.Leu9Val Uncertain significance Single submitter
- CST2 p.Met131Arg Uncertain significance Single submitter
- CST2 p.Phe106Ser Uncertain significance Single submitter
- CST2 p.Phe50Cys Uncertain significance Single submitter
- CST2 p.Ser53Ile Uncertain significance Single submitter
- CST2 p.Thr92Ala Uncertain significance Single submitter
- CST2 p.Tyr35Cys Uncertain significance Single submitter
- CST2 p.Tyr83Ser Uncertain significance Single submitter
- CST2 p.Val51Ile Uncertain significance Single submitter
- CST2 p.Val78Met Uncertain significance Single submitter
All CST2 variants
Benign 1
- p.Arg69Trp Multiple submitters ⚠
Likely benign 6
- c.229-3T>C Single submitter
- p.Arg43Trp Single submitter ⚠
- p.Asn135Lys Single submitter
- p.Gln15Leu Single submitter
- p.Ile77Thr Single submitter ⚠
- p.Ile93Thr Single submitter
Uncertain significance 41
- p.Ala16Val Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala58Val Single submitter ⚠
- p.Ala73Val Single submitter ⚠
- p.Arg130Gly Single submitter ⚠
- p.Arg28Lys Single submitter ⚠
- p.Arg46His Single submitter ⚠
- p.Arg72Gln Single submitter ⚠
- p.Asp129Asn Single submitter ⚠
- p.Asp38Glu Single submitter ⚠
- p.Asp38Gly Single submitter ⚠
- p.Asp61Glu Single submitter ⚠
- p.Asp86Asn Single submitter ⚠
- p.Cys118Ser Single submitter ⚠
- p.Cys94Tyr Single submitter ⚠
- p.Gln109Pro Single submitter ⚠
- p.Gln113Arg Single submitter ⚠
- p.Gln121Glu Single submitter ⚠
- p.Gln15His Single submitter ⚠
- p.Gln45Lys Single submitter ⚠
- p.Glu124Lys Single submitter ⚠
- p.Glu26Lys Single submitter ⚠
- p.Glu31Lys Single submitter ⚠
- p.Glu54Lys Single submitter ⚠
- p.Gly33Ser Single submitter ⚠
- p.His49Leu Single submitter ⚠
- p.Leu19Val Single submitter ⚠
- p.Leu9Val Single submitter ⚠
- p.Lys57Arg Single submitter ⚠
- p.Met131Arg Single submitter ⚠
- p.Met131Ile Single submitter ⚠
- p.Phe106Ser Single submitter ⚠
- p.Phe50Cys Single submitter ⚠
- p.Ser22Arg Single submitter ⚠
- p.Ser53Ile Single submitter ⚠
- p.Thr59Ser Single submitter ⚠
- p.Thr92Ala Single submitter ⚠
- p.Tyr35Cys Single submitter ⚠
- p.Tyr83Ser Single submitter ⚠
- p.Val51Ile Single submitter ⚠
- p.Val78Met Single submitter ⚠