CST5 — 32 ClinVar variants
All ClinVar germline CST5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
32 Uncertain significance
Full CST5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CST5 p.Ala23Thr Uncertain significance Single submitter
- CST5 p.Ala31Thr Uncertain significance Single submitter
- CST5 p.Ala36Val Uncertain significance Single submitter
- CST5 p.Cys46Phe Uncertain significance Single submitter
- CST5 p.Cys46Tyr Uncertain significance Single submitter
- CST5 p.Glu63Lys Uncertain significance Single submitter
- CST5 p.Gly80Val Uncertain significance Single submitter
- CST5 p.Lys57Glu Uncertain significance Single submitter
- CST5 p.Pro68Thr Uncertain significance Single submitter
- CST5 p.Tyr75Phe Uncertain significance Single submitter
- CST5 p.Val58Ile Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CST5 p.Ala51Val Uncertain significance Single submitter
- CST5 p.Arg140Trp Uncertain significance Single submitter
- CST5 p.Asn101Ser Uncertain significance Single submitter
- CST5 p.Asn83His Uncertain significance Single submitter
- CST5 p.Asp41Gly Uncertain significance Single submitter
- CST5 p.Glu117Asp Uncertain significance Single submitter
- CST5 p.Glu129Gly Uncertain significance Single submitter
- CST5 p.Glu54Ala Uncertain significance Single submitter
- CST5 p.Glu54Lys Uncertain significance Single submitter
- CST5 p.Ile34Thr Uncertain significance Single submitter
- CST5 p.Ile78Ser Uncertain significance Single submitter
- CST5 p.Leu113Pro Uncertain significance Single submitter
- CST5 p.Leu11Gln Uncertain significance Single submitter
- CST5 p.Lys97Arg Uncertain significance Single submitter
- CST5 p.Phe90Leu Uncertain significance Single submitter
- CST5 p.Thr96Ile Uncertain significance Single submitter
- CST5 p.Trp128Cys Uncertain significance Single submitter
- CST5 p.Tyr85Cys Uncertain significance Single submitter
- CST5 p.Tyr85His Uncertain significance Single submitter
- CST5 p.Val126Phe Uncertain significance Single submitter
- CST5 p.Val79Met Uncertain significance Single submitter
All CST5 variants
Uncertain significance 32
- p.Ala23Thr Single submitter ⚠
- p.Ala31Thr Single submitter ⚠
- p.Ala36Val Single submitter ⚠
- p.Ala51Val Single submitter ⚠
- p.Arg140Trp Single submitter ⚠
- p.Asn101Ser Single submitter ⚠
- p.Asn83His Single submitter ⚠
- p.Asp41Gly Single submitter ⚠
- p.Cys46Phe Single submitter ⚠
- p.Cys46Tyr Single submitter ⚠
- p.Glu117Asp Single submitter ⚠
- p.Glu129Gly Single submitter ⚠
- p.Glu54Ala Single submitter ⚠
- p.Glu54Lys Single submitter ⚠
- p.Glu63Lys Single submitter ⚠
- p.Gly80Val Single submitter ⚠
- p.Ile34Thr Single submitter ⚠
- p.Ile78Ser Single submitter ⚠
- p.Leu113Pro Single submitter ⚠
- p.Leu11Gln Single submitter ⚠
- p.Lys57Glu Single submitter ⚠
- p.Lys97Arg Single submitter ⚠
- p.Phe90Leu Single submitter ⚠
- p.Pro68Thr Single submitter ⚠
- p.Thr96Ile Single submitter ⚠
- p.Trp128Cys Single submitter ⚠
- p.Tyr75Phe Single submitter ⚠
- p.Tyr85Cys Single submitter ⚠
- p.Tyr85His Single submitter ⚠
- p.Val126Phe Single submitter ⚠
- p.Val58Ile Single submitter ⚠
- p.Val79Met Single submitter ⚠