CST8 — 31 ClinVar variants
All ClinVar germline CST8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
2 Likely benign · 29 Uncertain significance
Full CST8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CST8 p.Ala91Val Uncertain significance Single submitter
- CST8 p.Arg5Gln Uncertain significance Single submitter
- CST8 p.Asn27Lys Uncertain significance Single submitter
- CST8 p.Asn39Asp Uncertain significance Single submitter
- CST8 p.Cys105Gly Uncertain significance Single submitter
- CST8 p.Gln73Lys Uncertain significance Single submitter
- CST8 p.Gly124Arg Uncertain significance Single submitter
- CST8 p.Leu117Ser Uncertain significance Single submitter
- CST8 p.Lys26Gln Uncertain significance Single submitter
- CST8 p.Lys97Gln Uncertain significance Single submitter
- CST8 p.Ser120Arg Uncertain significance Single submitter
- CST8 p.Ser60Arg Uncertain significance Single submitter
- CST8 p.Val31Glu Uncertain significance Single submitter
- CST8 p.Val31Leu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CST8 p.Arg115Gly Uncertain significance Single submitter
- CST8 p.Asn102Asp Uncertain significance Single submitter
- CST8 p.Asn44Lys Uncertain significance Single submitter
- CST8 p.Asp94Tyr Uncertain significance Single submitter
- CST8 p.Glu59Gln Uncertain significance Single submitter
- CST8 p.Ile86Thr Uncertain significance Single submitter
- CST8 p.Leu122Ser Uncertain significance Single submitter
- CST8 p.Leu76Pro Uncertain significance Single submitter
- CST8 p.Ser60Asn Uncertain significance Single submitter
- CST8 p.Ser60Gly Uncertain significance Single submitter
- CST8 p.Ser93Arg Uncertain significance Single submitter
- CST8 p.Ser93Gly Uncertain significance Single submitter
- CST8 p.Thr29Ala Uncertain significance Single submitter
- CST8 p.Trp50Arg Uncertain significance Single submitter
- CST8 p.Val45Met Uncertain significance Single submitter
All CST8 variants
Likely benign 2
- p.Pro15Leu Single submitter
- p.Val38Ile Single submitter
Uncertain significance 29
- p.Ala91Val Single submitter ⚠
- p.Arg115Gly Single submitter ⚠
- p.Arg5Gln Single submitter ⚠
- p.Asn102Asp Single submitter ⚠
- p.Asn27Lys Single submitter ⚠
- p.Asn39Asp Single submitter ⚠
- p.Asn44Lys Single submitter ⚠
- p.Asp94Tyr Single submitter ⚠
- p.Cys105Gly Single submitter ⚠
- p.Gln73Lys Single submitter ⚠
- p.Glu59Gln Single submitter ⚠
- p.Gly124Arg Single submitter ⚠
- p.Ile86Thr Single submitter ⚠
- p.Leu117Ser Single submitter ⚠
- p.Leu122Ser Single submitter ⚠
- p.Leu76Pro Single submitter ⚠
- p.Lys26Gln Single submitter ⚠
- p.Lys97Gln Single submitter ⚠
- p.Ser120Arg Single submitter ⚠
- p.Ser60Arg Single submitter ⚠
- p.Ser60Asn Single submitter ⚠
- p.Ser60Gly Single submitter ⚠
- p.Ser93Arg Single submitter ⚠
- p.Ser93Gly Single submitter ⚠
- p.Thr29Ala Single submitter ⚠
- p.Trp50Arg Single submitter ⚠
- p.Val31Glu Single submitter ⚠
- p.Val31Leu Single submitter ⚠
- p.Val45Met Single submitter ⚠