CST9 — 32 ClinVar variants
All ClinVar germline CST9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
4 Likely benign · 28 Uncertain significance
Full CST9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CST9 p.Ala9Thr Uncertain significance Single submitter
- CST9 p.Arg7Lys Uncertain significance Single submitter
- CST9 p.Arg99Cys Uncertain significance Single submitter
- CST9 p.Arg99His Uncertain significance Single submitter
- CST9 p.Asn123Asp Uncertain significance Single submitter
- CST9 p.Asn123Ser Uncertain significance Single submitter
- CST9 p.Asn38His Uncertain significance Single submitter
- CST9 p.Asn39Lys Uncertain significance Single submitter
- CST9 p.Asp111Gly Uncertain significance Single submitter
- CST9 p.Asp150Gly Uncertain significance Single submitter
- CST9 p.Glu65Lys Uncertain significance Single submitter
- CST9 p.Gly137Glu Uncertain significance Single submitter
- CST9 p.Gly141Glu Uncertain significance Single submitter
- CST9 p.Gly143Val Uncertain significance Single submitter
- CST9 p.Ile153Phe Uncertain significance Single submitter
- CST9 p.Lys151Ile Uncertain significance Single submitter
- CST9 p.Lys157Gln Uncertain significance Single submitter
- CST9 p.Lys8Glu Uncertain significance Single submitter
- CST9 p.Met35Arg Uncertain significance Single submitter
- CST9 p.Ser135Gly Uncertain significance Single submitter
- CST9 p.Val102Ile Uncertain significance Single submitter
- CST9 p.Val124Ile Uncertain significance Single submitter
- CST9 p.Val133Gly Uncertain significance Single submitter
- CST9 p.Val60Met Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All CST9 variants
Likely benign 4
- p.Asn59= Single submitter
- p.Met46Val Single submitter
- p.Pro154Leu Single submitter
- p.Val60Leu Single submitter
Uncertain significance 28
- p.Ala13Ser Single submitter ⚠
- p.Ala9Thr Single submitter ⚠
- p.Arg78Ser Single submitter ⚠
- p.Arg7Lys Single submitter ⚠
- p.Arg99Cys Single submitter ⚠
- p.Arg99His Single submitter ⚠
- p.Asn123Asp Single submitter ⚠
- p.Asn123Ser Single submitter ⚠
- p.Asn38His Single submitter ⚠
- p.Asn39Lys Single submitter ⚠
- p.Asp111Gly Single submitter ⚠
- p.Asp150Gly Single submitter ⚠
- p.Asp44Tyr Single submitter ⚠
- p.Glu65Lys Single submitter ⚠
- p.Gly137Glu Single submitter ⚠
- p.Gly141Glu Single submitter ⚠
- p.Gly143Val Single submitter ⚠
- p.Ile153Phe Single submitter ⚠
- p.Lys151Ile Single submitter ⚠
- p.Lys157Gln Single submitter ⚠
- p.Lys8Glu Single submitter ⚠
- p.Met35Arg Single submitter ⚠
- p.Phe58Leu Single submitter ⚠
- p.Ser135Gly Single submitter ⚠
- p.Val102Ile Single submitter ⚠
- p.Val124Ile Single submitter ⚠
- p.Val133Gly Single submitter ⚠
- p.Val60Met Single submitter ⚠