CST9L — 22 ClinVar variants
All ClinVar germline CST9L variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
22 Uncertain significance
Full CST9L gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CST9L p.Cys37Tyr Uncertain significance Single submitter
- CST9L p.Gln111Arg Uncertain significance Single submitter
- CST9L p.Lys7Thr Uncertain significance Single submitter
- CST9L p.Met43Val Uncertain significance Single submitter
- CST9L p.Ser127Arg Uncertain significance Single submitter
- CST9L p.Trp12Arg Uncertain significance Single submitter
- CST9L p.Tyr46Asn Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- CST9L p.Asp64Tyr Uncertain significance Single submitter
- CST9L p.Cys142Arg Uncertain significance Single submitter
- CST9L p.Cys142Trp Uncertain significance Single submitter
- CST9L p.Ile73Met Uncertain significance Single submitter
- CST9L p.Leu17Pro Uncertain significance Single submitter
- CST9L p.Leu25Pro Uncertain significance Single submitter
- CST9L p.Leu74Phe Uncertain significance Single submitter
- CST9L p.Phe124Cys Uncertain significance Single submitter
- CST9L p.Phe53Ser Uncertain significance Single submitter
- CST9L p.Pro48Leu Uncertain significance Single submitter
- CST9L p.Pro48Ser Uncertain significance Single submitter
- CST9L p.Ser76Tyr Uncertain significance Single submitter
- CST9L p.Thr57Ile Uncertain significance Single submitter
- CST9L p.Tyr66Cys Uncertain significance Single submitter
- CST9L p.Val81Ala Uncertain significance Single submitter
All CST9L variants
Uncertain significance 22
- p.Asp64Tyr Single submitter ⚠
- p.Cys142Arg Single submitter ⚠
- p.Cys142Trp Single submitter ⚠
- p.Cys37Tyr Single submitter ⚠
- p.Gln111Arg Single submitter ⚠
- p.Ile73Met Single submitter ⚠
- p.Leu17Pro Single submitter ⚠
- p.Leu25Pro Single submitter ⚠
- p.Leu74Phe Single submitter ⚠
- p.Lys7Thr Single submitter ⚠
- p.Met43Val Single submitter ⚠
- p.Phe124Cys Single submitter ⚠
- p.Phe53Ser Single submitter ⚠
- p.Pro48Leu Single submitter ⚠
- p.Pro48Ser Single submitter ⚠
- p.Ser127Arg Single submitter ⚠
- p.Ser76Tyr Single submitter ⚠
- p.Thr57Ile Single submitter ⚠
- p.Trp12Arg Single submitter ⚠
- p.Tyr46Asn Single submitter ⚠
- p.Tyr66Cys Single submitter ⚠
- p.Val81Ala Single submitter ⚠