CSTF3 — 27 ClinVar variants
All ClinVar germline CSTF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
27 Uncertain significance
Full CSTF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CSTF3 p.Ala59Val Uncertain significance Single submitter
- CSTF3 p.Arg51Trp Uncertain significance Single submitter
- CSTF3 p.Arg644Gln Uncertain significance Single submitter
- CSTF3 p.Asp404Tyr Uncertain significance Single submitter
- CSTF3 p.Gln587Glu Uncertain significance Single submitter
- CSTF3 p.Gly672Ser Uncertain significance Single submitter
- CSTF3 p.Ile183Val Uncertain significance Single submitter
- CSTF3 p.Ile451Thr Uncertain significance Single submitter
- CSTF3 p.Ile501Arg Uncertain significance Single submitter
- CSTF3 p.Ile567Val Uncertain significance Single submitter
- CSTF3 p.Ile659Leu Uncertain significance Single submitter
- CSTF3 p.Lys439Thr Uncertain significance Single submitter
- CSTF3 p.Met93Leu Uncertain significance Single submitter
- CSTF3 p.Pro673Leu Uncertain significance Single submitter
- CSTF3 p.Ser305Arg Uncertain significance Single submitter
- CSTF3 p.Thr414Ser Uncertain significance Single submitter
- CSTF3 p.Val562Ala Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- CSTF3 p.Arg551Pro Uncertain significance Single submitter
- CSTF3 p.Asn148Ser Uncertain significance Single submitter
- CSTF3 p.Cys628Tyr Uncertain significance Single submitter
- CSTF3 p.Gly196Asp Uncertain significance Single submitter
- CSTF3 p.Gly661Cys Uncertain significance Single submitter
- CSTF3 p.Pro29Ser Uncertain significance Single submitter
- CSTF3 p.Pro477Arg Uncertain significance Single submitter
- CSTF3 p.Val411Ile Uncertain significance Single submitter
- CSTF3 p.Val684Ile Uncertain significance Single submitter
- CSTF3 p.Val700Ile Uncertain significance Single submitter
All CSTF3 variants
Uncertain significance 27
- p.Ala59Val Single submitter ⚠
- p.Arg51Trp Single submitter ⚠
- p.Arg551Pro Single submitter ⚠
- p.Arg644Gln Single submitter ⚠
- p.Asn148Ser Single submitter ⚠
- p.Asp404Tyr Single submitter ⚠
- p.Cys628Tyr Single submitter ⚠
- p.Gln587Glu Single submitter ⚠
- p.Gly196Asp Single submitter ⚠
- p.Gly661Cys Single submitter ⚠
- p.Gly672Ser Single submitter ⚠
- p.Ile183Val Single submitter ⚠
- p.Ile451Thr Single submitter ⚠
- p.Ile501Arg Single submitter ⚠
- p.Ile567Val Single submitter ⚠
- p.Ile659Leu Single submitter ⚠
- p.Lys439Thr Single submitter ⚠
- p.Met93Leu Single submitter ⚠
- p.Pro29Ser Single submitter ⚠
- p.Pro477Arg Single submitter ⚠
- p.Pro673Leu Single submitter ⚠
- p.Ser305Arg Single submitter ⚠
- p.Thr414Ser Single submitter ⚠
- p.Val411Ile Single submitter ⚠
- p.Val562Ala Single submitter ⚠
- p.Val684Ile Single submitter ⚠
- p.Val700Ile Single submitter ⚠