CT45A3 — 11 ClinVar variants
All ClinVar germline CT45A3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
2 Likely benign · 9 Uncertain significance
Full CT45A3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CT45A3 p.Glu13Ala Uncertain significance Single submitter
- CT45A3 p.Gly41Arg Uncertain significance Single submitter
- CT45A3 p.Lys29Gln Uncertain significance Single submitter
- CT45A3 p.Met52Val Uncertain significance Single submitter
- CT45A3 p.Ser26Leu Uncertain significance Single submitter
- CT45A3 p.Ser45Asn Uncertain significance Single submitter
- CT45A3 p.Thr5Arg Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All CT45A3 variants
Likely benign 2
- p.Arg20Gly Single submitter
- p.Lys56Asn Single submitter
Uncertain significance 9
- p.Arg18Cys Single submitter ⚠
- p.Arg30Met Single submitter
- p.Glu13Ala Single submitter ⚠
- p.Gly41Arg Single submitter ⚠
- p.Lys29Gln Single submitter ⚠
- p.Met52Val Single submitter ⚠
- p.Ser26Leu Single submitter ⚠
- p.Ser45Asn Single submitter ⚠
- p.Thr5Arg Single submitter ⚠