CT55 — 13 ClinVar variants
All ClinVar germline CT55 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 11 flagged for review →
1 Pathogenic · 1 Likely benign · 11 Uncertain significance
Full CT55 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 11
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 8
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CT55 p.Ala104Ser Uncertain significance Single submitter
- CT55 p.Ala166Thr Uncertain significance Single submitter
- CT55 p.Arg99Cys Uncertain significance Single submitter
- CT55 p.Asp83Gly Uncertain significance Single submitter
- CT55 p.Glu152Lys Uncertain significance Single submitter
- CT55 p.Glu55Gly Uncertain significance Single submitter
- CT55 p.Ile161Phe Uncertain significance Single submitter
- CT55 p.Leu150Trp Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CT55 variants
Pathogenic 1
- p.Tyr155Ter No assertion criteria spermatogenic failure, X-linked, 7
Likely benign 1
- p.Arg99His Single submitter
Uncertain significance 11
- p.Ala104Ser Single submitter ⚠
- p.Ala166Ser Single submitter ⚠
- p.Ala166Thr Single submitter ⚠
- p.Arg99Cys Single submitter ⚠
- p.Asp149Asn Single submitter ⚠
- p.Asp83Gly Single submitter ⚠
- p.Glu152Lys Single submitter ⚠
- p.Glu55Gly Single submitter ⚠
- p.Ile161Phe Single submitter ⚠
- p.Leu150Trp Single submitter ⚠
- p.Thr38Ala Single submitter ⚠