CT83 — 11 ClinVar variants
All ClinVar germline CT83 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
1 Likely benign · 10 Uncertain significance
Full CT83 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 5
The independent predictors disagree with each other — read with care.
All CT83 variants
Likely benign 1
- p.Ala37Ser Single submitter
Uncertain significance 10
- p.Ala75Val Single submitter ⚠
- p.Arg23His Single submitter ⚠
- p.Arg64Trp Single submitter ⚠
- p.Gln77His Single submitter ⚠
- p.Ile74Thr Single submitter ⚠
- p.Ile74Val Single submitter ⚠
- p.Leu98Val Single submitter ⚠
- p.Ser112Phe Single submitter ⚠
- p.Ser9Asn Single submitter ⚠
- p.Val82Ala Single submitter ⚠