CTAG2 — 45 ClinVar variants
All ClinVar germline CTAG2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
6 Benign · 5 Likely benign · 34 Uncertain significance
Full CTAG2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTAG2 c.404+107C>A Uncertain significance Single submitter
- CTAG2 c.404+21G>C Uncertain significance Single submitter
- CTAG2 c.404+35C>T Uncertain significance Single submitter
- CTAG2 c.404+60T>C Uncertain significance Single submitter
- CTAG2 c.404+74C>A Uncertain significance Single submitter
- CTAG2 c.404+81G>A Uncertain significance Single submitter
- CTAG2 c.405-112G>T Uncertain significance Single submitter
- CTAG2 c.405-35C>T Uncertain significance Single submitter
- CTAG2 c.405-39G>A Uncertain significance Single submitter
- CTAG2 c.405-71C>T Uncertain significance Single submitter
- CTAG2 p.Ala48Ser Uncertain significance Single submitter
- CTAG2 p.Ala48Thr Uncertain significance Single submitter
- CTAG2 p.Asp73Gly Uncertain significance Single submitter
- CTAG2 p.Asp84His Uncertain significance Single submitter
- CTAG2 p.Gly42Ser Uncertain significance Single submitter
- CTAG2 p.Ile23Thr Uncertain significance Single submitter
- CTAG2 p.Pro115Leu Uncertain significance Single submitter
- CTAG2 p.Pro61Arg Uncertain significance Single submitter
- CTAG2 p.Pro61Ser Uncertain significance Single submitter
- CTAG2 p.Ser110Ala Uncertain significance Single submitter
- CTAG2 p.Ser54Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CTAG2 c.404+42G>A Uncertain significance Single submitter
- CTAG2 p.Ala71Val Uncertain significance Single submitter
- CTAG2 p.Arg46Trp Uncertain significance Single submitter
- CTAG2 p.Arg6Gln Benign Single submitter
- CTAG2 p.Asn131Lys Uncertain significance Single submitter
- CTAG2 p.Glu4Lys Uncertain significance Single submitter
- CTAG2 p.Gly22Asp Uncertain significance Single submitter
- CTAG2 p.Gly44Asp Uncertain significance Single submitter
- CTAG2 p.Pro56Leu Uncertain significance Single submitter
- CTAG2 p.Pro61Leu Uncertain significance Single submitter
- CTAG2 p.Pro64Leu Uncertain significance Single submitter
- CTAG2 p.Pro99Leu Uncertain significance Single submitter
- CTAG2 p.Ser11Trp Uncertain significance Single submitter
- CTAG2 p.Val128Met Uncertain significance Single submitter
All CTAG2 variants
Benign 6
- c.405-93G>C Multiple submitters
- p.Met94Val Multiple submitters
- p.Pro99Ala Multiple submitters
- p.Arg6Gln Single submitter ⚠
- p.Glu89Gln Single submitter
- p.Pro115= Single submitter
Likely benign 5
- c.405-28T>C Multiple submitters
- p.Ala114Thr Single submitter
- p.Ala3= Single submitter
- p.Gly67Ser Single submitter
- p.Ser157Pro Single submitter
Uncertain significance 34
- c.404+107C>A Single submitter ⚠
- c.404+21G>C Single submitter ⚠
- c.404+35C>T Single submitter ⚠
- c.404+42G>A Single submitter ⚠
- c.404+60T>C Single submitter ⚠
- c.404+74C>A Single submitter ⚠
- c.404+81G>A Single submitter ⚠
- c.405-112G>T Single submitter ⚠
- c.405-35C>T Single submitter ⚠
- c.405-39G>A Single submitter ⚠
- c.405-71C>T Single submitter ⚠
- p.Ala48Ser Single submitter ⚠
- p.Ala48Thr Single submitter ⚠
- p.Ala71Val Single submitter ⚠
- p.Arg46Trp Single submitter ⚠
- p.Asn131Lys Single submitter ⚠
- p.Asp73Gly Single submitter ⚠
- p.Asp84His Single submitter ⚠
- p.Glu4Lys Single submitter ⚠
- p.Gly22Asp Single submitter ⚠
- p.Gly42Ser Single submitter ⚠
- p.Gly44Asp Single submitter ⚠
- p.Ile23Thr Single submitter ⚠
- p.Pro115Leu Single submitter ⚠
- p.Pro56Leu Single submitter ⚠
- p.Pro61Arg Single submitter ⚠
- p.Pro61Leu Single submitter ⚠
- p.Pro61Ser Single submitter ⚠
- p.Pro64Leu Single submitter ⚠
- p.Pro99Leu Single submitter ⚠
- p.Ser110Ala Single submitter ⚠
- p.Ser11Trp Single submitter ⚠
- p.Ser54Leu Single submitter ⚠
- p.Val128Met Single submitter ⚠