CTAGE4 — 72 ClinVar variants
All ClinVar germline CTAGE4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Conflicting · 5 Likely benign · 66 Uncertain significance
Full CTAGE4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTAGE4 p.Ala168Val Uncertain significance Single submitter
- CTAGE4 p.Ala191Thr Uncertain significance Single submitter
- CTAGE4 p.Ala668Thr Uncertain significance Single submitter
- CTAGE4 p.Arg205Gln Uncertain significance Single submitter
- CTAGE4 p.Arg205Leu Uncertain significance Single submitter
- CTAGE4 p.Arg205Trp Uncertain significance Single submitter
- CTAGE4 p.Arg625Ser Uncertain significance Single submitter
- CTAGE4 p.Arg625Thr Uncertain significance Single submitter
- CTAGE4 p.Arg635Gly Uncertain significance Single submitter
- CTAGE4 p.Asn292Asp Uncertain significance Single submitter
- CTAGE4 p.Asn325Ser Uncertain significance Single submitter
- CTAGE4 p.Asn674Ile Uncertain significance Single submitter
- CTAGE4 p.Asp169Ala Uncertain significance Single submitter
- CTAGE4 p.Asp290Asn Uncertain significance Single submitter
- CTAGE4 p.Asp309Asn Uncertain significance Single submitter
- CTAGE4 p.Asp651Asn Uncertain significance Single submitter
- CTAGE4 p.Asp667Val Uncertain significance Single submitter
- CTAGE4 p.Asp709Asn Uncertain significance Single submitter
- CTAGE4 p.Gln100Arg Uncertain significance Single submitter
- CTAGE4 p.Glu294Lys Uncertain significance Single submitter
- CTAGE4 p.Gly304Asp Uncertain significance Single submitter
- CTAGE4 p.Gly313Arg Uncertain significance Single submitter
- CTAGE4 p.Gly613Arg Uncertain significance Single submitter
- CTAGE4 p.Gly690Ala Uncertain significance Single submitter
- CTAGE4 p.Gly703Ser Uncertain significance Single submitter
- CTAGE4 p.Gly727Arg Uncertain significance Single submitter
- CTAGE4 p.Leu293Val Uncertain significance Single submitter
- CTAGE4 p.Leu295Ser Uncertain significance Single submitter
- CTAGE4 p.Leu672Phe Uncertain significance Single submitter
- CTAGE4 p.Lys151Glu Uncertain significance Single submitter
- CTAGE4 p.Met729Arg Uncertain significance Single submitter
- CTAGE4 p.Phe227Ser Uncertain significance Single submitter
- CTAGE4 p.Pro623Leu Uncertain significance Single submitter
- CTAGE4 p.Ser201Gly Uncertain significance Single submitter
- CTAGE4 p.Ser330Asn Uncertain significance Single submitter
- CTAGE4 p.Ser659Pro Uncertain significance Single submitter
- CTAGE4 p.Ser659Thr Uncertain significance Single submitter
- CTAGE4 p.Ser702Arg Uncertain significance Single submitter
- CTAGE4 p.Thr221Ser Uncertain significance Single submitter
- CTAGE4 p.Thr288Arg Uncertain significance Single submitter
- CTAGE4 p.Thr288Met Uncertain significance Single submitter
- CTAGE4 p.Thr689Ala Uncertain significance Single submitter
- CTAGE4 p.Trp301Arg Uncertain significance Single submitter
- CTAGE4 p.Val282Met Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- CTAGE4 p.Ala751Val Uncertain significance Single submitter
- CTAGE4 p.Arg605His Uncertain significance Single submitter
- CTAGE4 p.Arg734Gln Uncertain significance Single submitter
- CTAGE4 p.Asp261Val Uncertain significance Single submitter
- CTAGE4 p.Asp651His Uncertain significance Single submitter
- CTAGE4 p.Asp671Tyr Uncertain significance Single submitter
- CTAGE4 p.Lys252Glu Uncertain significance Single submitter
- CTAGE4 p.Lys267Met Uncertain significance Single submitter
- CTAGE4 p.Lys277Thr Uncertain significance Single submitter
- CTAGE4 p.Met752Lys Uncertain significance Single submitter
- CTAGE4 p.Pro551Leu Uncertain significance Single submitter
- CTAGE4 p.Pro696Leu Uncertain significance Single submitter
- CTAGE4 p.Pro700Ser Uncertain significance Single submitter
- CTAGE4 p.Pro739Ser Uncertain significance Single submitter
- CTAGE4 p.Pro746Leu Uncertain significance Single submitter
- CTAGE4 p.Pro758Leu Uncertain significance Single submitter
- CTAGE4 p.Pro762Thr Uncertain significance Single submitter
- CTAGE4 p.Pro767Arg Uncertain significance Single submitter
- CTAGE4 p.Pro767Leu Uncertain significance Single submitter
- CTAGE4 p.Ser633Cys Uncertain significance Single submitter
- CTAGE4 p.Ser663Cys Uncertain significance Single submitter
- CTAGE4 p.Tyr581Cys Likely benign Single submitter
- CTAGE4 p.Tyr764Cys Uncertain significance Single submitter
All CTAGE4 variants
Conflicting classifications of pathogenicity 1
- p.Ser680Ala Single submitter ⚠
Likely benign 5
- p.His254= Single submitter
- p.Ile585Thr Single submitter
- p.Met275Lys Single submitter
- p.Thr533Met Single submitter
- p.Tyr581Cys Single submitter ⚠
Uncertain significance 66
- p.Ala168Val Single submitter ⚠
- p.Ala191Thr Single submitter ⚠
- p.Ala668Thr Single submitter ⚠
- p.Ala751Val Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg205Leu Single submitter ⚠
- p.Arg205Trp Single submitter ⚠
- p.Arg605His Single submitter ⚠
- p.Arg625Ser Single submitter ⚠
- p.Arg625Thr Single submitter ⚠
- p.Arg635Gly Single submitter ⚠
- p.Arg734Gln Single submitter ⚠
- p.Asn292Asp Single submitter ⚠
- p.Asn325Ser Single submitter ⚠
- p.Asn674Ile Single submitter ⚠
- p.Asp169Ala Single submitter ⚠
- p.Asp261Val Single submitter ⚠
- p.Asp290Asn Single submitter ⚠
- p.Asp309Asn Single submitter ⚠
- p.Asp651Asn Single submitter ⚠
- p.Asp651His Single submitter ⚠
- p.Asp667Val Single submitter ⚠
- p.Asp671Tyr Single submitter ⚠
- p.Asp709Asn Single submitter ⚠
- p.Gln100Arg Single submitter ⚠
- p.Glu294Lys Single submitter ⚠
- p.Gly304Asp Single submitter ⚠
- p.Gly313Arg Single submitter ⚠
- p.Gly613Arg Single submitter ⚠
- p.Gly690Ala Single submitter ⚠
- p.Gly703Ser Single submitter ⚠
- p.Gly727Arg Single submitter ⚠
- p.Leu293Val Single submitter ⚠
- p.Leu295Ser Single submitter ⚠
- p.Leu672Phe Single submitter ⚠
- p.Lys151Glu Single submitter ⚠
- p.Lys252Glu Single submitter ⚠
- p.Lys267Met Single submitter ⚠
- p.Lys277Thr Single submitter ⚠
- p.Met729Arg Single submitter ⚠
- p.Met752Lys Single submitter ⚠
- p.Phe227Ser Single submitter ⚠
- p.Pro551Leu Single submitter ⚠
- p.Pro623Leu Single submitter ⚠
- p.Pro696Leu Single submitter ⚠
- p.Pro700Ser Single submitter ⚠
- p.Pro739Ser Single submitter ⚠
- p.Pro746Leu Single submitter ⚠
- p.Pro758Leu Single submitter ⚠
- p.Pro762Thr Single submitter ⚠
- p.Pro767Arg Single submitter ⚠
- p.Pro767Leu Single submitter ⚠
- p.Ser201Gly Single submitter ⚠
- p.Ser330Asn Single submitter ⚠
- p.Ser633Cys Single submitter ⚠
- p.Ser659Pro Single submitter ⚠
- p.Ser659Thr Single submitter ⚠
- p.Ser663Cys Single submitter ⚠
- p.Ser702Arg Single submitter ⚠
- p.Thr221Ser Single submitter ⚠
- p.Thr288Arg Single submitter ⚠
- p.Thr288Met Single submitter ⚠
- p.Thr689Ala Single submitter ⚠
- p.Trp301Arg Single submitter ⚠
- p.Tyr764Cys Single submitter ⚠
- p.Val282Met Single submitter ⚠