CTAGE6 — 76 ClinVar variants
All ClinVar germline CTAGE6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
1 Benign · 12 Likely benign · 63 Uncertain significance
Full CTAGE6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTAGE6 p.Ala321Pro Uncertain significance Single submitter
- CTAGE6 p.Ala322Val Uncertain significance Single submitter
- CTAGE6 p.Ala437Thr Uncertain significance Single submitter
- CTAGE6 p.Ala484Pro Uncertain significance Single submitter
- CTAGE6 p.Ala484Val Uncertain significance Single submitter
- CTAGE6 p.Arg126Gln Uncertain significance Single submitter
- CTAGE6 p.Arg204Gln Uncertain significance Single submitter
- CTAGE6 p.Arg205Gln Uncertain significance Single submitter
- CTAGE6 p.Arg205Trp Uncertain significance Single submitter
- CTAGE6 p.Arg425Cys Uncertain significance Single submitter
- CTAGE6 p.Arg529His Uncertain significance Single submitter
- CTAGE6 p.Asp308Gly Uncertain significance Single submitter
- CTAGE6 p.Asp346Asn Uncertain significance Single submitter
- CTAGE6 p.Gln225Arg Uncertain significance Single submitter
- CTAGE6 p.Gln341Arg Uncertain significance Single submitter
- CTAGE6 p.Gln488Glu Uncertain significance Single submitter
- CTAGE6 p.Glu302Gly Uncertain significance Single submitter
- CTAGE6 p.Glu443Asp Uncertain significance Single submitter
- CTAGE6 p.Glu473Val Uncertain significance Single submitter
- CTAGE6 p.Gly304Asp Uncertain significance Single submitter
- CTAGE6 p.His320Tyr Uncertain significance Single submitter
- CTAGE6 p.Leu318Val Uncertain significance Single submitter
- CTAGE6 p.Leu537Pro Uncertain significance Single submitter
- CTAGE6 p.Lys235Glu Uncertain significance Single submitter
- CTAGE6 p.Lys418Arg Uncertain significance Single submitter
- CTAGE6 p.Met167Lys Uncertain significance Single submitter
- CTAGE6 p.Met276Val Uncertain significance Single submitter
- CTAGE6 p.Pro310Ala Uncertain significance Single submitter
- CTAGE6 p.Pro310Thr Uncertain significance Single submitter
- CTAGE6 p.Pro520Leu Uncertain significance Single submitter
- CTAGE6 p.Pro525Ser Uncertain significance Single submitter
- CTAGE6 p.Pro561Leu Uncertain significance Single submitter
- CTAGE6 p.Ser183Thr Uncertain significance Single submitter
- CTAGE6 p.Ser222Thr Uncertain significance Single submitter
- CTAGE6 p.Ser299Arg Uncertain significance Single submitter
- CTAGE6 p.Ser299Asn Uncertain significance Single submitter
- CTAGE6 p.Thr287Ala Uncertain significance Single submitter
- CTAGE6 p.Thr447Ser Uncertain significance Single submitter
- CTAGE6 p.Tyr372His Uncertain significance Single submitter
- CTAGE6 p.Tyr399Cys Uncertain significance Single submitter
- CTAGE6 p.Tyr451His Uncertain significance Single submitter
- CTAGE6 p.Val455Leu Uncertain significance Single submitter
- CTAGE6 p.Val72Met Uncertain significance Single submitter
Predictors split 22
The independent predictors disagree with each other — read with care.
- CTAGE6 p.Ala322Gly Uncertain significance Single submitter
- CTAGE6 p.Arg461Gly Uncertain significance Single submitter
- CTAGE6 p.Arg470Trp Uncertain significance Single submitter
- CTAGE6 p.Glu155Gln Likely benign Single submitter
- CTAGE6 p.Glu180Lys Uncertain significance Single submitter
- CTAGE6 p.Glu249Gln Uncertain significance Single submitter
- CTAGE6 p.Glu411Gly Uncertain significance Single submitter
- CTAGE6 p.Glu428Gly Uncertain significance Single submitter
- CTAGE6 p.Glu441Asp Uncertain significance Single submitter
- CTAGE6 p.Ile188Met Uncertain significance Single submitter
- CTAGE6 p.Ile266Thr Uncertain significance Single submitter
- CTAGE6 p.Leu213Phe Uncertain significance Single submitter
- CTAGE6 p.Leu352Val Uncertain significance Single submitter
- CTAGE6 p.Leu359Ile Uncertain significance Single submitter
- CTAGE6 p.Leu423Ile Likely benign Single submitter
- CTAGE6 p.Leu430Met Uncertain significance Single submitter
- CTAGE6 p.Leu476Val Uncertain significance Single submitter
- CTAGE6 p.Leu479Val Uncertain significance Single submitter
- CTAGE6 p.Lys323Met Uncertain significance Single submitter
- CTAGE6 p.Lys502Glu Uncertain significance Single submitter
- CTAGE6 p.Ser239Arg Uncertain significance Single submitter
- CTAGE6 p.Val345Glu Uncertain significance Single submitter
All CTAGE6 variants
Benign 1
- p.Glu364Ala Multiple submitters
Likely benign 12
- p.Ala524Ser Single submitter
- p.Ala620Thr Single submitter
- p.Arg425His Single submitter
- p.Arg583Lys Single submitter
- p.Asp290Asn Single submitter
- p.Cys605Arg Single submitter
- p.Gln76Lys Single submitter
- p.Glu124Ala Single submitter
- p.Glu155Gln Single submitter ⚠
- p.Leu423Ile Single submitter ⚠
- p.Lys606Arg Single submitter
- p.Ser639Pro Single submitter
Uncertain significance 63
- p.Ala321Pro Single submitter ⚠
- p.Ala322Gly Single submitter ⚠
- p.Ala322Val Single submitter ⚠
- p.Ala437Thr Single submitter ⚠
- p.Ala484Pro Single submitter ⚠
- p.Ala484Val Single submitter ⚠
- p.Arg126Gln Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg205Trp Single submitter ⚠
- p.Arg425Cys Single submitter ⚠
- p.Arg461Gly Single submitter ⚠
- p.Arg470Trp Single submitter ⚠
- p.Arg529His Single submitter ⚠
- p.Asp308Gly Single submitter ⚠
- p.Asp346Asn Single submitter ⚠
- p.Gln225Arg Single submitter ⚠
- p.Gln341Arg Single submitter ⚠
- p.Gln488Glu Single submitter ⚠
- p.Glu180Lys Single submitter ⚠
- p.Glu249Gln Single submitter ⚠
- p.Glu302Gly Single submitter ⚠
- p.Glu411Gly Single submitter ⚠
- p.Glu428Gly Single submitter ⚠
- p.Glu441Asp Single submitter ⚠
- p.Glu443Asp Single submitter ⚠
- p.Glu473Val Single submitter ⚠
- p.Gly304Asp Single submitter ⚠
- p.His320Tyr Single submitter ⚠
- p.Ile188Met Single submitter ⚠
- p.Ile266Thr Single submitter ⚠
- p.Leu213Phe Single submitter ⚠
- p.Leu318Val Single submitter ⚠
- p.Leu352Val Single submitter ⚠
- p.Leu359Ile Single submitter ⚠
- p.Leu430Met Single submitter ⚠
- p.Leu476Val Single submitter ⚠
- p.Leu479Val Single submitter ⚠
- p.Leu537Pro Single submitter ⚠
- p.Lys235Glu Single submitter ⚠
- p.Lys323Met Single submitter ⚠
- p.Lys418Arg Single submitter ⚠
- p.Lys502Glu Single submitter ⚠
- p.Met167Lys Single submitter ⚠
- p.Met276Val Single submitter ⚠
- p.Pro310Ala Single submitter ⚠
- p.Pro310Thr Single submitter ⚠
- p.Pro520Leu Single submitter ⚠
- p.Pro525Ser Single submitter ⚠
- p.Pro561Leu Single submitter ⚠
- p.Ser183Thr Single submitter ⚠
- p.Ser222Thr Single submitter ⚠
- p.Ser239Arg Single submitter ⚠
- p.Ser299Arg Single submitter ⚠
- p.Ser299Asn Single submitter ⚠
- p.Thr287Ala Single submitter ⚠
- p.Thr447Ser Single submitter ⚠
- p.Tyr372His Single submitter ⚠
- p.Tyr399Cys Single submitter ⚠
- p.Tyr451His Single submitter ⚠
- p.Val345Glu Single submitter ⚠
- p.Val455Leu Single submitter ⚠
- p.Val72Met Single submitter ⚠