CTNNBIP1 — 10 ClinVar variants
All ClinVar germline CTNNBIP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
10 Uncertain significance
Full CTNNBIP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTNNBIP1 p.Asn49Asp Uncertain significance Single submitter
- CTNNBIP1 p.Glu37Lys Uncertain significance Single submitter
- CTNNBIP1 p.Ile16Val Uncertain significance Single submitter
- CTNNBIP1 p.Leu55Pro Uncertain significance Single submitter
- CTNNBIP1 p.Met25Val Uncertain significance Single submitter
- CTNNBIP1 p.Pro57Leu Uncertain significance Single submitter
- CTNNBIP1 p.Tyr44Cys Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CTNNBIP1 variants
Uncertain significance 10
- p.Arg79Trp Single submitter ⚠
- p.Asn49Asp Single submitter ⚠
- p.Glu37Lys Single submitter ⚠
- p.Ile16Val Single submitter ⚠
- p.Leu55Pro Single submitter ⚠
- p.Met25Val Single submitter ⚠
- p.Pro11Leu Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Tyr44Cys Single submitter ⚠
- p.Val48Gly Single submitter ⚠