CTRB1 — 67 ClinVar variants
All ClinVar germline CTRB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
10 Likely benign · 57 Uncertain significance
Full CTRB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTRB1 p.Ala177Val Uncertain significance Single submitter
- CTRB1 p.Arg248Cys Uncertain significance Single submitter
- CTRB1 p.Asp145Asn Uncertain significance Single submitter
- CTRB1 p.Asp236Asn Uncertain significance Single submitter
- CTRB1 p.Asp68Glu Uncertain significance Single submitter
- CTRB1 p.Asp90Asn Uncertain significance Single submitter
- CTRB1 p.Asp90Gly Uncertain significance Single submitter
- CTRB1 p.Cys186Gly Uncertain significance Single submitter
- CTRB1 p.Cys60Tyr Uncertain significance Single submitter
- CTRB1 p.Glu95Lys Uncertain significance Single submitter
- CTRB1 p.Gly202Arg Uncertain significance Single submitter
- CTRB1 p.Gly234Asp Uncertain significance Single submitter
- CTRB1 p.Gly30Ser Uncertain significance Single submitter
- CTRB1 p.Gly77Arg Uncertain significance Single submitter
- CTRB1 p.His25Asn Uncertain significance Single submitter
- CTRB1 p.Ile230Thr Uncertain significance Single submitter
- CTRB1 p.Lys258Thr Uncertain significance Single submitter
- CTRB1 p.Phe10Leu Uncertain significance Single submitter
- CTRB1 p.Phe112Leu Uncertain significance Single submitter
- CTRB1 p.Pro170Leu Uncertain significance Single submitter
- CTRB1 p.Pro216Leu Uncertain significance Single submitter
- CTRB1 p.Ser213Pro Uncertain significance Single submitter
- CTRB1 p.Thr240Ile Uncertain significance Single submitter
- CTRB1 p.Val197Ala Uncertain significance Single submitter
- CTRB1 p.Val231Leu Uncertain significance Single submitter
- CTRB1 p.Val35Met Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- CTRB1 p.Ala104Asp Uncertain significance Single submitter
- CTRB1 p.Ala138Thr Uncertain significance Single submitter
- CTRB1 p.Ala144Thr Uncertain significance Single submitter
- CTRB1 p.Ala150Ser Uncertain significance Single submitter
- CTRB1 p.Ala150Thr Likely benign Single submitter
- CTRB1 p.Ala261Val Uncertain significance Single submitter
- CTRB1 p.Ala40Thr Uncertain significance Single submitter
- CTRB1 p.Arg131Cys Uncertain significance Single submitter
- CTRB1 p.Arg131His Uncertain significance Single submitter
- CTRB1 p.Arg33Lys Uncertain significance Single submitter
- CTRB1 p.Asn183Ser Uncertain significance Single submitter
- CTRB1 p.Asp171Glu Uncertain significance Single submitter
- CTRB1 p.Asp196Asn Uncertain significance Single submitter
- CTRB1 p.Glu185Ala Uncertain significance Single submitter
- CTRB1 p.Gly215Ser Uncertain significance Single submitter
- CTRB1 p.Gly223Ala Uncertain significance Single submitter
- CTRB1 p.Gly234Ser Uncertain significance Single submitter
- CTRB1 p.Gly56Ser Uncertain significance Single submitter
- CTRB1 p.Leu7Phe Uncertain significance Single submitter
- CTRB1 p.Leu7Pro Uncertain significance Single submitter
- CTRB1 p.Pro149Leu Uncertain significance Single submitter
- CTRB1 p.Pro42Leu Uncertain significance Single submitter
- CTRB1 p.Ser241Phe Uncertain significance Single submitter
- CTRB1 p.Ser66Asn Uncertain significance Single submitter
- CTRB1 p.Ser81Phe Uncertain significance Single submitter
- CTRB1 p.Val100Ile Uncertain significance Single submitter
- CTRB1 p.Val197Met Uncertain significance Single submitter
- CTRB1 p.Val41Ala Uncertain significance Single submitter
- CTRB1 p.Val41Ile Uncertain significance Single submitter
- CTRB1 p.Val83Met Uncertain significance Single submitter
- CTRB1 p.Val85Met Uncertain significance Single submitter
All CTRB1 variants
Likely benign 10
- p.Ala144= Single submitter
- p.Ala150Thr Single submitter ⚠
- p.Ala184Thr Single submitter
- p.Arg193Lys Single submitter
- p.Asn97Asp Single submitter
- p.Pro254= Single submitter
- p.Ser189Phe Single submitter
- p.Ser3Phe Single submitter
- p.Ser66= Single submitter
- p.Ser81= Single submitter
Uncertain significance 57
- p.Ala104Asp Single submitter ⚠
- p.Ala138Thr Single submitter ⚠
- p.Ala144Thr Single submitter ⚠
- p.Ala150Ser Single submitter ⚠
- p.Ala177Val Single submitter ⚠
- p.Ala261Val Single submitter ⚠
- p.Ala40Thr Single submitter ⚠
- p.Arg131Cys Single submitter ⚠
- p.Arg131His Single submitter ⚠
- p.Arg248Cys Single submitter ⚠
- p.Arg33Lys Single submitter ⚠
- p.Asn183Ser Single submitter ⚠
- p.Asp145Asn Single submitter ⚠
- p.Asp171Glu Single submitter ⚠
- p.Asp196Asn Single submitter ⚠
- p.Asp236Asn Single submitter ⚠
- p.Asp68Glu Single submitter ⚠
- p.Asp90Asn Single submitter ⚠
- p.Asp90Gly Single submitter ⚠
- p.Cys186Gly Single submitter ⚠
- p.Cys60Tyr Single submitter ⚠
- p.Glu185Ala Single submitter ⚠
- p.Glu95Lys Single submitter ⚠
- p.Gly202Arg Single submitter ⚠
- p.Gly215Ser Single submitter ⚠
- p.Gly223Ala Single submitter ⚠
- p.Gly234Asp Single submitter ⚠
- p.Gly234Ser Single submitter ⚠
- p.Gly30Ser Single submitter ⚠
- p.Gly56Ser Single submitter ⚠
- p.Gly77Arg Single submitter ⚠
- p.His25Asn Single submitter ⚠
- p.Ile230Thr Single submitter ⚠
- p.Leu7Phe Single submitter ⚠
- p.Leu7Pro Single submitter ⚠
- p.Lys258Thr Single submitter ⚠
- p.Phe10Leu Single submitter ⚠
- p.Phe112Leu Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Pro170Leu Single submitter ⚠
- p.Pro216Leu Single submitter ⚠
- p.Pro42Leu Single submitter ⚠
- p.Ser213Pro Single submitter ⚠
- p.Ser241Phe Single submitter ⚠
- p.Ser66Asn Single submitter ⚠
- p.Ser81Phe Single submitter ⚠
- p.Thr240Ile Single submitter ⚠
- p.Val100Ile Single submitter ⚠
- p.Val197Ala Single submitter ⚠
- p.Val197Met Single submitter ⚠
- p.Val231Leu Single submitter ⚠
- p.Val35Met Single submitter ⚠
- p.Val41Ala Single submitter ⚠
- p.Val41Ile Single submitter ⚠
- p.Val83Met Single submitter ⚠
- p.Val85Met Single submitter ⚠
- p.Gly211= No assertion criteria prostate cancer