CTRB2 — 46 ClinVar variants
All ClinVar germline CTRB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
2 Likely benign · 44 Uncertain significance
Full CTRB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTRB2 p.Arg236Cys Uncertain significance Single submitter
- CTRB2 p.Arg248Cys Uncertain significance Single submitter
- CTRB2 p.Asn167Tyr Uncertain significance Single submitter
- CTRB2 p.Glu95Lys Uncertain significance Single submitter
- CTRB2 p.Gly202Arg Uncertain significance Single submitter
- CTRB2 p.Gly20Ala Uncertain significance Single submitter
- CTRB2 p.Ile114Thr Uncertain significance Single submitter
- CTRB2 p.Ile194Asn Uncertain significance Single submitter
- CTRB2 p.Ile230Thr Uncertain significance Single submitter
- CTRB2 p.Ile24Val Uncertain significance Single submitter
- CTRB2 p.Met198Ile Uncertain significance Single submitter
- CTRB2 p.Met210Val Uncertain significance Single submitter
- CTRB2 p.Phe57Leu Uncertain significance Single submitter
- CTRB2 p.Ser207Phe Uncertain significance Single submitter
- CTRB2 p.Ser232Pro Uncertain significance Single submitter
- CTRB2 p.Ser44Phe Uncertain significance Single submitter
- CTRB2 p.Thr72Asn Uncertain significance Single submitter
- CTRB2 p.Trp255Arg Uncertain significance Single submitter
- CTRB2 p.Trp5Leu Uncertain significance Single submitter
- CTRB2 p.Val139Met Uncertain significance Single submitter
- CTRB2 p.Val197Ala Uncertain significance Single submitter
- CTRB2 p.Val21Ile Uncertain significance Single submitter
- CTRB2 p.Val245Met Uncertain significance Single submitter
Predictors split 21
The independent predictors disagree with each other — read with care.
- CTRB2 p.Ala11Thr Uncertain significance Single submitter
- CTRB2 p.Ala138Thr Uncertain significance Single submitter
- CTRB2 p.Ala244Thr Uncertain significance Single submitter
- CTRB2 p.Arg131His Uncertain significance Single submitter
- CTRB2 p.Arg236His Uncertain significance Single submitter
- CTRB2 p.Asp196Asn Uncertain significance Single submitter
- CTRB2 p.Glu185Lys Uncertain significance Single submitter
- CTRB2 p.Glu38Asp Uncertain significance Single submitter
- CTRB2 p.Glu88Gln Uncertain significance Single submitter
- CTRB2 p.Glu96Gly Uncertain significance Single submitter
- CTRB2 p.Glu96Lys Uncertain significance Single submitter
- CTRB2 p.Gly14Ala Uncertain significance Single submitter
- CTRB2 p.Gly223Arg Uncertain significance Single submitter
- CTRB2 p.Gly43Ser Uncertain significance Single submitter
- CTRB2 p.Gly56Ser Uncertain significance Single submitter
- CTRB2 p.Ile121Leu Uncertain significance Single submitter
- CTRB2 p.Lys188Asn Uncertain significance Single submitter
- CTRB2 p.Pro170Thr Uncertain significance Single submitter
- CTRB2 p.Pro179Ala Uncertain significance Single submitter
- CTRB2 p.Val206Ile Uncertain significance Single submitter
- CTRB2 p.Val85Met Uncertain significance Single submitter
All CTRB2 variants
Likely benign 2
- p.Arg236Gly Single submitter
- p.Leu141= Single submitter
Uncertain significance 44
- p.Ala11Thr Single submitter ⚠
- p.Ala138Thr Single submitter ⚠
- p.Ala244Thr Single submitter ⚠
- p.Arg131His Single submitter ⚠
- p.Arg236Cys Single submitter ⚠
- p.Arg236His Single submitter ⚠
- p.Arg248Cys Single submitter ⚠
- p.Asn167Tyr Single submitter ⚠
- p.Asp196Asn Single submitter ⚠
- p.Glu185Lys Single submitter ⚠
- p.Glu38Asp Single submitter ⚠
- p.Glu88Gln Single submitter ⚠
- p.Glu95Lys Single submitter ⚠
- p.Glu96Gly Single submitter ⚠
- p.Glu96Lys Single submitter ⚠
- p.Gly14Ala Single submitter ⚠
- p.Gly202Arg Single submitter ⚠
- p.Gly20Ala Single submitter ⚠
- p.Gly223Arg Single submitter ⚠
- p.Gly43Ser Single submitter ⚠
- p.Gly56Ser Single submitter ⚠
- p.Ile114Thr Single submitter ⚠
- p.Ile121Leu Single submitter ⚠
- p.Ile194Asn Single submitter ⚠
- p.Ile230Thr Single submitter ⚠
- p.Ile24Val Single submitter ⚠
- p.Lys188Asn Single submitter ⚠
- p.Met198Ile Single submitter ⚠
- p.Met210Val Single submitter ⚠
- p.Phe57Leu Single submitter ⚠
- p.Pro170Thr Single submitter ⚠
- p.Pro179Ala Single submitter ⚠
- p.Ser207Phe Single submitter ⚠
- p.Ser232Pro Single submitter ⚠
- p.Ser44Phe Single submitter ⚠
- p.Thr72Asn Single submitter ⚠
- p.Trp255Arg Single submitter ⚠
- p.Trp5Leu Single submitter ⚠
- p.Val139Met Single submitter ⚠
- p.Val197Ala Single submitter ⚠
- p.Val206Ile Single submitter ⚠
- p.Val21Ile Single submitter ⚠
- p.Val245Met Single submitter ⚠
- p.Val85Met Single submitter ⚠