CTSE — 85 ClinVar variants
All ClinVar germline CTSE variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 77 flagged for review →
9 Likely benign · 76 Uncertain significance
Full CTSE gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 77
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTSE p.Gly80Asp Uncertain significance Multiple submitters
- CTSE p.Ala206Thr Uncertain significance Single submitter
- CTSE p.Arg23Ser Uncertain significance Single submitter
- CTSE p.Arg28Ser Uncertain significance Single submitter
- CTSE p.Arg37Gln Uncertain significance Single submitter
- CTSE p.Arg384Cys Uncertain significance Single submitter
- CTSE p.Arg384His Uncertain significance Single submitter
- CTSE p.Asn101Lys Uncertain significance Single submitter
- CTSE p.Asn50Asp Uncertain significance Single submitter
- CTSE p.Asp151Asn Uncertain significance Single submitter
- CTSE p.Asp178Val Uncertain significance Single submitter
- CTSE p.Asp261Val Uncertain significance Single submitter
- CTSE p.Asp343His Uncertain significance Single submitter
- CTSE p.Asp372Tyr Uncertain significance Single submitter
- CTSE p.Asp63Tyr Uncertain significance Single submitter
- CTSE p.Cys114Phe Uncertain significance Single submitter
- CTSE p.Cys351Ser Uncertain significance Single submitter
- CTSE p.Gln89Pro Uncertain significance Single submitter
- CTSE p.Glu16Lys Uncertain significance Single submitter
- CTSE p.Glu171Gln Uncertain significance Single submitter
- CTSE p.Glu58Lys Uncertain significance Single submitter
- CTSE p.Gly142Arg Uncertain significance Single submitter
- CTSE p.Gly188Arg Uncertain significance Single submitter
- CTSE p.His49Arg Uncertain significance Single submitter
- CTSE p.Ile287Asn Uncertain significance Single submitter
- CTSE p.Leu26Phe Uncertain significance Single submitter
- CTSE p.Lys295Met Uncertain significance Single submitter
- CTSE p.Lys35Gln Uncertain significance Single submitter
- CTSE p.Met205Val Uncertain significance Single submitter
- CTSE p.Met214Ile Uncertain significance Single submitter
- CTSE p.Met270Thr Uncertain significance Single submitter
- CTSE p.Met53Thr Uncertain significance Single submitter
- CTSE p.Met76Val Uncertain significance Single submitter
- CTSE p.Phe45Leu Uncertain significance Single submitter
- CTSE p.Pro213Leu Uncertain significance Single submitter
- CTSE p.Pro30Leu Uncertain significance Single submitter
- CTSE p.Pro321Leu Uncertain significance Single submitter
- CTSE p.Pro69Ser Uncertain significance Single submitter
- CTSE p.Ser111Arg Uncertain significance Single submitter
- CTSE p.Ser229Asn Uncertain significance Single submitter
- CTSE p.Ser239Pro Uncertain significance Single submitter
- CTSE p.Ser31Tyr Uncertain significance Single submitter
- CTSE p.Ser65Gly Uncertain significance Single submitter
- CTSE p.Thr333Ser Uncertain significance Single submitter
- CTSE p.Trp103Cys Uncertain significance Single submitter
- CTSE p.Val345Ala Uncertain significance Single submitter
- CTSE p.Val389Gly Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- CTSE p.Ala259Pro Uncertain significance Single submitter
- CTSE p.Arg23Trp Uncertain significance Single submitter
- CTSE p.Arg37Trp Uncertain significance Single submitter
- CTSE p.Arg388His Uncertain significance Single submitter
- CTSE p.Asn203Lys Uncertain significance Single submitter
- CTSE p.Asn262Asp Uncertain significance Single submitter
- CTSE p.Asn318Tyr Uncertain significance Single submitter
- CTSE p.Gln41His Uncertain significance Single submitter
- CTSE p.Glu230Lys Uncertain significance Single submitter
- CTSE p.Gly19Glu Uncertain significance Single submitter
- CTSE p.Gly243Glu Uncertain significance Single submitter
- CTSE p.Gly266Glu Uncertain significance Single submitter
- CTSE p.Gly267Asp Uncertain significance Single submitter
- CTSE p.Gly329Arg Uncertain significance Single submitter
- CTSE p.His22Gln Uncertain significance Single submitter
- CTSE p.Ile279Val Uncertain significance Single submitter
- CTSE p.Ile301Leu Uncertain significance Single submitter
- CTSE p.Ile327Val Uncertain significance Single submitter
- CTSE p.Leu21Pro Uncertain significance Single submitter
- CTSE p.Leu286Phe Uncertain significance Single submitter
- CTSE p.Leu4Phe Uncertain significance Single submitter
- CTSE p.Lys252Glu Uncertain significance Single submitter
- CTSE p.Pro122Leu Uncertain significance Single submitter
- CTSE p.Pro213Gln Uncertain significance Single submitter
- CTSE p.Pro249Thr Uncertain significance Single submitter
- CTSE p.Ser191Ala Uncertain significance Single submitter
- CTSE p.Val160Met Uncertain significance Single submitter
- CTSE p.Val248Phe Uncertain significance Single submitter
- CTSE p.Val306Met Likely benign Single submitter
-
CTSE p.Val107Met
Uncertain significance
No assertion criteria
prostate cancer
All CTSE variants
Likely benign 9
Uncertain significance 76
- p.Gly80Asp Multiple submitters ⚠
- p.Ala206Thr Single submitter ⚠
- p.Ala259Pro Single submitter ⚠
- p.Arg23Ser Single submitter ⚠
- p.Arg23Trp Single submitter ⚠
- p.Arg28Ser Single submitter ⚠
- p.Arg37Gln Single submitter ⚠
- p.Arg37Trp Single submitter ⚠
- p.Arg384Cys Single submitter ⚠
- p.Arg384His Single submitter ⚠
- p.Arg388His Single submitter ⚠
- p.Asn101Lys Single submitter ⚠
- p.Asn203Lys Single submitter ⚠
- p.Asn262Asp Single submitter ⚠
- p.Asn318Tyr Single submitter ⚠
- p.Asn50Asp Single submitter ⚠
- p.Asp151Asn Single submitter ⚠
- p.Asp178Val Single submitter ⚠
- p.Asp261Val Single submitter ⚠
- p.Asp343His Single submitter ⚠
- p.Asp372Tyr Single submitter ⚠
- p.Asp63Tyr Single submitter ⚠
- p.Cys114Phe Single submitter ⚠
- p.Cys351Ser Single submitter ⚠
- p.Gln41His Single submitter ⚠
- p.Gln89Pro Single submitter ⚠
- p.Glu16Lys Single submitter ⚠
- p.Glu171Gln Single submitter ⚠
- p.Glu230Lys Single submitter ⚠
- p.Glu58Lys Single submitter ⚠
- p.Gly142Arg Single submitter ⚠
- p.Gly188Arg Single submitter ⚠
- p.Gly19Glu Single submitter ⚠
- p.Gly243Glu Single submitter ⚠
- p.Gly266Glu Single submitter ⚠
- p.Gly267Asp Single submitter ⚠
- p.Gly329Arg Single submitter ⚠
- p.His22Gln Single submitter ⚠
- p.His49Arg Single submitter ⚠
- p.Ile279Val Single submitter ⚠
- p.Ile287Asn Single submitter ⚠
- p.Ile301Leu Single submitter ⚠
- p.Ile327Val Single submitter ⚠
- p.Leu21Pro Single submitter ⚠
- p.Leu26Phe Single submitter ⚠
- p.Leu286Phe Single submitter ⚠
- p.Leu4Phe Single submitter ⚠
- p.Lys252Glu Single submitter ⚠
- p.Lys295Met Single submitter ⚠
- p.Lys35Gln Single submitter ⚠
- p.Met205Val Single submitter ⚠
- p.Met214Ile Single submitter ⚠
- p.Met270Thr Single submitter ⚠
- p.Met53Thr Single submitter ⚠
- p.Met76Val Single submitter ⚠
- p.Phe45Leu Single submitter ⚠
- p.Pro122Leu Single submitter ⚠
- p.Pro213Gln Single submitter ⚠
- p.Pro213Leu Single submitter ⚠
- p.Pro249Thr Single submitter ⚠
- p.Pro30Leu Single submitter ⚠
- p.Pro321Leu Single submitter ⚠
- p.Pro69Ser Single submitter ⚠
- p.Ser111Arg Single submitter ⚠
- p.Ser191Ala Single submitter ⚠
- p.Ser229Asn Single submitter ⚠
- p.Ser239Pro Single submitter ⚠
- p.Ser31Tyr Single submitter ⚠
- p.Ser65Gly Single submitter ⚠
- p.Thr333Ser Single submitter ⚠
- p.Trp103Cys Single submitter ⚠
- p.Val160Met Single submitter ⚠
- p.Val248Phe Single submitter ⚠
- p.Val345Ala Single submitter ⚠
- p.Val389Gly Single submitter ⚠
- p.Val107Met No assertion criteria prostate cancer ⚠