CTSG — 34 ClinVar variants
All ClinVar germline CTSG variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
4 Benign · 4 Likely benign · 26 Uncertain significance
Full CTSG gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTSG p.Arg116Gly Uncertain significance Single submitter
- CTSG p.Arg120Gln Uncertain significance Single submitter
- CTSG p.Arg153Trp Uncertain significance Single submitter
- CTSG p.Arg154Lys Uncertain significance Single submitter
- CTSG p.Arg174His Uncertain significance Single submitter
- CTSG p.Arg55Pro Uncertain significance Single submitter
- CTSG p.Asn209Ser Uncertain significance Single submitter
- CTSG p.Asn84Thr Uncertain significance Single submitter
- CTSG p.Cys65Gly Uncertain significance Single submitter
- CTSG p.Cys65Trp Uncertain significance Single submitter
- CTSG p.Glu20Lys Uncertain significance Single submitter
- CTSG p.Gly15Arg Uncertain significance Single submitter
- CTSG p.Gly75Asp Uncertain significance Single submitter
- CTSG p.Leu112Phe Uncertain significance Single submitter
- CTSG p.Met251Val Uncertain significance Single submitter
- CTSG p.Ser216Phe Uncertain significance Single submitter
- CTSG p.Ser42Gly Uncertain significance Single submitter
- CTSG p.Thr143Ser Uncertain significance Single submitter
- CTSG p.Thr253Ser Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- CTSG p.Arg32His Likely benign Single submitter
- CTSG p.Arg96Leu Uncertain significance Single submitter
- CTSG p.Asn209Ile Uncertain significance Single submitter
- CTSG p.Asp57Glu Uncertain significance Single submitter
- CTSG p.Ser31Ala Uncertain significance Single submitter
- CTSG p.Tyr217Cys Uncertain significance Single submitter
All CTSG variants
Benign 4
- p.Asn125Ser Multiple submitters
- p.Gly15Ala Multiple submitters
- p.Thr90Ile Multiple submitters
- p.Phe176= Single submitter
Likely benign 4
- p.Arg32His Single submitter ⚠
- p.Gly155Arg Single submitter
- p.Gly199= Single submitter
- p.Val231Ile Single submitter
Uncertain significance 26
- p.Arg116Gly Single submitter ⚠
- p.Arg120Gln Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Arg154Lys Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg55Pro Single submitter ⚠
- p.Arg96Cys Single submitter
- p.Arg96Leu Single submitter ⚠
- p.Asn123Lys Single submitter
- p.Asn209Ile Single submitter ⚠
- p.Asn209Ser Single submitter ⚠
- p.Asn84Thr Single submitter ⚠
- p.Asp57Glu Single submitter ⚠
- p.Cys65Gly Single submitter ⚠
- p.Cys65Trp Single submitter ⚠
- p.Glu20Lys Single submitter ⚠
- p.Gly15Arg Single submitter ⚠
- p.Gly75Asp Single submitter ⚠
- p.Leu112Phe Single submitter ⚠
- p.Met251Val Single submitter ⚠
- p.Ser216Phe Single submitter ⚠
- p.Ser31Ala Single submitter ⚠
- p.Ser42Gly Single submitter ⚠
- p.Thr143Ser Single submitter ⚠
- p.Thr253Ser Single submitter ⚠
- p.Tyr217Cys Single submitter ⚠