CTSS — 21 ClinVar variants
All ClinVar germline CTSS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
2 Benign · 2 Likely benign · 17 Uncertain significance
Full CTSS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTSS p.Asp120Ala Uncertain significance Single submitter
- CTSS p.Asp74Asn Uncertain significance Single submitter
- CTSS p.His27Gln Uncertain significance Single submitter
- CTSS p.Lys178Asn Uncertain significance Single submitter
- CTSS p.Lys33Asn Uncertain significance Single submitter
- CTSS p.Val282Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- CTSS p.Ala243Thr Uncertain significance Single submitter
- CTSS p.Gly176Val Uncertain significance Single submitter
- CTSS p.Ile193Thr Uncertain significance Single submitter
- CTSS p.Lys212Gln Uncertain significance Single submitter
- CTSS p.Lys37Arg Uncertain significance Single submitter
- CTSS p.Met83Val Uncertain significance Single submitter
- CTSS p.Ser118Ala Uncertain significance Single submitter
- CTSS p.Thr186Lys Uncertain significance Single submitter
- CTSS p.Thr187Met Uncertain significance Single submitter
- CTSS p.Thr223Ala Uncertain significance Single submitter
- CTSS p.Val283Ile Uncertain significance Single submitter
All CTSS variants
Benign 2
- p.Val296= Multiple submitters
- c.627+9T>A Single submitter
Likely benign 2
- p.Arg113Gln Single submitter
- p.Arg3Trp Single submitter
Uncertain significance 17
- p.Ala243Thr Single submitter ⚠
- p.Asp120Ala Single submitter ⚠
- p.Asp74Asn Single submitter ⚠
- p.Gly176Val Single submitter ⚠
- p.His27Gln Single submitter ⚠
- p.Ile193Thr Single submitter ⚠
- p.Lys178Asn Single submitter ⚠
- p.Lys212Gln Single submitter ⚠
- p.Lys33Asn Single submitter ⚠
- p.Lys37Arg Single submitter ⚠
- p.Met83Val Single submitter ⚠
- p.Ser118Ala Single submitter ⚠
- p.Thr186Lys Single submitter ⚠
- p.Thr187Met Single submitter ⚠
- p.Thr223Ala Single submitter ⚠
- p.Val282Ala Single submitter ⚠
- p.Val283Ile Single submitter ⚠