CTSW — 67 ClinVar variants
All ClinVar germline CTSW variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
3 Likely benign · 64 Uncertain significance
Full CTSW gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTSW p.Ala109Gly Uncertain significance Single submitter
- CTSW p.Ala28Val Uncertain significance Single submitter
- CTSW p.Arg107Lys Uncertain significance Single submitter
- CTSW p.Arg186Cys Uncertain significance Single submitter
- CTSW p.Arg186His Uncertain significance Single submitter
- CTSW p.Arg62Cys Uncertain significance Single submitter
- CTSW p.Asn151Lys Uncertain significance Single submitter
- CTSW p.Asn265Lys Uncertain significance Single submitter
- CTSW p.Asp183Glu Uncertain significance Single submitter
- CTSW p.Asp64His Uncertain significance Single submitter
- CTSW p.Cys150Arg Uncertain significance Single submitter
- CTSW p.Cys150Trp Uncertain significance Single submitter
- CTSW p.Cys352Arg Uncertain significance Single submitter
- CTSW p.Cys374Tyr Uncertain significance Single submitter
- CTSW p.Gln244His Uncertain significance Single submitter
- CTSW p.Gln287His Uncertain significance Single submitter
- CTSW p.Gln77His Uncertain significance Single submitter
- CTSW p.Gly306Arg Uncertain significance Single submitter
- CTSW p.Gly32Arg Uncertain significance Single submitter
- CTSW p.Gly348Val Uncertain significance Single submitter
- CTSW p.Ile141Val Uncertain significance Single submitter
- CTSW p.Ile162Arg Uncertain significance Single submitter
- CTSW p.Ile201Val Uncertain significance Single submitter
- CTSW p.Ile250Thr Uncertain significance Single submitter
- CTSW p.Ile264Ser Uncertain significance Single submitter
- CTSW p.Ile264Val Uncertain significance Single submitter
- CTSW p.Leu165Pro Uncertain significance Single submitter
- CTSW p.Lys267Glu Uncertain significance Single submitter
- CTSW p.Lys267Thr Uncertain significance Single submitter
- CTSW p.Met266Thr Uncertain significance Single submitter
- CTSW p.Phe49Leu Uncertain significance Single submitter
- CTSW p.Phe99Ser Uncertain significance Single submitter
- CTSW p.Ser8Pro Uncertain significance Single submitter
- CTSW p.Thr164Asn Uncertain significance Single submitter
- CTSW p.Val112Ile Uncertain significance Single submitter
- CTSW p.Val176Ile Uncertain significance Single submitter
- CTSW p.Val363Met Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- CTSW p.Ala140Thr Uncertain significance Single submitter
- CTSW p.Ala41Asp Uncertain significance Single submitter
- CTSW p.Ala41Thr Uncertain significance Single submitter
- CTSW p.Ala71Thr Uncertain significance Single submitter
- CTSW p.Arg135Gln Uncertain significance Single submitter
- CTSW p.Arg167Cys Uncertain significance Single submitter
- CTSW p.Arg344Trp Uncertain significance Single submitter
- CTSW p.Arg347Gln Uncertain significance Single submitter
- CTSW p.Arg362His Uncertain significance Single submitter
- CTSW p.Arg51Trp Uncertain significance Single submitter
- CTSW p.Asn206Asp Uncertain significance Single submitter
- CTSW p.Asn206Lys Uncertain significance Single submitter
- CTSW p.Asn206Ser Uncertain significance Single submitter
- CTSW p.Ile65Asn Uncertain significance Single submitter
- CTSW p.Ile65Phe Uncertain significance Single submitter
- CTSW p.Leu102Ile Uncertain significance Single submitter
- CTSW p.Pro358Leu Uncertain significance Single submitter
- CTSW p.Pro35Leu Uncertain significance Single submitter
- CTSW p.Pro370Ser Uncertain significance Single submitter
- CTSW p.Pro375Ala Uncertain significance Single submitter
- CTSW p.Ser114Asn Uncertain significance Single submitter
- CTSW p.Thr261Ile Uncertain significance Single submitter
- CTSW p.Val174Ala Uncertain significance Single submitter
- CTSW p.Val178Leu Uncertain significance Single submitter
- CTSW p.Val178Met Uncertain significance Single submitter
- CTSW p.Val203Ala Uncertain significance Single submitter
- CTSW p.Val262Met Uncertain significance Single submitter
All CTSW variants
Likely benign 3
- p.Arg273Gln Single submitter
- p.Gln244Pro Single submitter
- p.Leu10fs Single submitter
Uncertain significance 64
- p.Ala109Gly Single submitter ⚠
- p.Ala140Thr Single submitter ⚠
- p.Ala28Val Single submitter ⚠
- p.Ala41Asp Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Ala71Thr Single submitter ⚠
- p.Arg107Lys Single submitter ⚠
- p.Arg135Gln Single submitter ⚠
- p.Arg167Cys Single submitter ⚠
- p.Arg186Cys Single submitter ⚠
- p.Arg186His Single submitter ⚠
- p.Arg344Trp Single submitter ⚠
- p.Arg347Gln Single submitter ⚠
- p.Arg362His Single submitter ⚠
- p.Arg51Trp Single submitter ⚠
- p.Arg62Cys Single submitter ⚠
- p.Asn151Lys Single submitter ⚠
- p.Asn206Asp Single submitter ⚠
- p.Asn206Lys Single submitter ⚠
- p.Asn206Ser Single submitter ⚠
- p.Asn265Lys Single submitter ⚠
- p.Asp183Glu Single submitter ⚠
- p.Asp64His Single submitter ⚠
- p.Cys150Arg Single submitter ⚠
- p.Cys150Trp Single submitter ⚠
- p.Cys352Arg Single submitter ⚠
- p.Cys374Tyr Single submitter ⚠
- p.Gln244His Single submitter ⚠
- p.Gln287His Single submitter ⚠
- p.Gln77His Single submitter ⚠
- p.Gly306Arg Single submitter ⚠
- p.Gly32Arg Single submitter ⚠
- p.Gly348Val Single submitter ⚠
- p.Ile141Val Single submitter ⚠
- p.Ile162Arg Single submitter ⚠
- p.Ile201Val Single submitter ⚠
- p.Ile250Thr Single submitter ⚠
- p.Ile264Ser Single submitter ⚠
- p.Ile264Val Single submitter ⚠
- p.Ile65Asn Single submitter ⚠
- p.Ile65Phe Single submitter ⚠
- p.Leu102Ile Single submitter ⚠
- p.Leu165Pro Single submitter ⚠
- p.Lys267Glu Single submitter ⚠
- p.Lys267Thr Single submitter ⚠
- p.Met266Thr Single submitter ⚠
- p.Phe49Leu Single submitter ⚠
- p.Phe99Ser Single submitter ⚠
- p.Pro358Leu Single submitter ⚠
- p.Pro35Leu Single submitter ⚠
- p.Pro370Ser Single submitter ⚠
- p.Pro375Ala Single submitter ⚠
- p.Ser114Asn Single submitter ⚠
- p.Ser8Pro Single submitter ⚠
- p.Thr164Asn Single submitter ⚠
- p.Thr261Ile Single submitter ⚠
- p.Val112Ile Single submitter ⚠
- p.Val174Ala Single submitter ⚠
- p.Val176Ile Single submitter ⚠
- p.Val178Leu Single submitter ⚠
- p.Val178Met Single submitter ⚠
- p.Val203Ala Single submitter ⚠
- p.Val262Met Single submitter ⚠
- p.Val363Met Single submitter ⚠