CTTN — 98 ClinVar variants
All ClinVar germline CTTN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
2 Benign · 7 Likely benign · 89 Uncertain significance
Full CTTN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTTN p.Ala17Val Uncertain significance Single submitter
- CTTN p.Ala19Ser Uncertain significance Single submitter
- CTTN p.Ala424Val Uncertain significance Single submitter
- CTTN p.Arg454Gln Uncertain significance Single submitter
- CTTN p.Asp25His Uncertain significance Single submitter
- CTTN p.Asp365Glu Uncertain significance Single submitter
- CTTN p.Asp487Asn Uncertain significance Single submitter
- CTTN p.Gln459Arg Uncertain significance Single submitter
- CTTN p.Gln459Pro Uncertain significance Single submitter
- CTTN p.Glu488Asp Uncertain significance Single submitter
- CTTN p.Gly143Arg Uncertain significance Single submitter
- CTTN p.Gly197Ser Uncertain significance Single submitter
- CTTN p.Gly307Ser Uncertain significance Single submitter
- CTTN p.Gly308Arg Uncertain significance Single submitter
- CTTN p.His478Arg Uncertain significance Single submitter
- CTTN p.His82Tyr Uncertain significance Single submitter
- CTTN p.Leu391Gln Uncertain significance Single submitter
- CTTN p.Lys193Thr Uncertain significance Single submitter
- CTTN p.Phe306Val Uncertain significance Single submitter
- CTTN p.Pro480Ser Uncertain significance Single submitter
- CTTN p.Pro480Thr Uncertain significance Single submitter
- CTTN p.Ser458Arg Uncertain significance Single submitter
- CTTN p.Thr323Ala Uncertain significance Single submitter
- CTTN p.Thr399Met Uncertain significance Single submitter
- CTTN p.Thr440Pro Uncertain significance Single submitter
- CTTN p.Val115Met Uncertain significance Single submitter
- CTTN p.Val445Ala Uncertain significance Single submitter
Predictors split 34
The independent predictors disagree with each other — read with care.
- CTTN p.Ala395Gly Uncertain significance Single submitter
- CTTN p.Arg316Gln Uncertain significance Single submitter
- CTTN p.Arg316Trp Uncertain significance Single submitter
- CTTN p.Arg367Gln Uncertain significance Single submitter
- CTTN p.Arg376Gln Uncertain significance Single submitter
- CTTN p.Arg381Gln Uncertain significance Single submitter
- CTTN p.Asp508Asn Uncertain significance Single submitter
- CTTN p.Gln216Lys Uncertain significance Single submitter
- CTTN p.Gln243Lys Uncertain significance Single submitter
- CTTN p.Gln363His Uncertain significance Single submitter
- CTTN p.Glu146Gln Uncertain significance Single submitter
- CTTN p.Glu254Asp Uncertain significance Single submitter
- CTTN p.Glu341Lys Uncertain significance Single submitter
- CTTN p.Glu385Gln Uncertain significance Single submitter
- CTTN p.Glu443Asp Uncertain significance Single submitter
- CTTN p.Glu60Asp Uncertain significance Single submitter
- CTTN p.His56Arg Uncertain significance Single submitter
- CTTN p.Ile350Val Uncertain significance Single submitter
- CTTN p.Lys161Arg Uncertain significance Single submitter
- CTTN p.Lys171Arg Uncertain significance Single submitter
- CTTN p.Lys193Arg Uncertain significance Single submitter
- CTTN p.Lys221Arg Uncertain significance Single submitter
- CTTN p.Pro476Leu Uncertain significance Single submitter
- CTTN p.Ser155Cys Uncertain significance Single submitter
- CTTN p.Ser303Cys Uncertain significance Single submitter
- CTTN p.Ser418Arg Uncertain significance Single submitter
- CTTN p.Ser98Leu Uncertain significance Single submitter
- CTTN p.Thr219Met Uncertain significance Single submitter
- CTTN p.Tyr162Cys Uncertain significance Single submitter
- CTTN p.Tyr421Cys Uncertain significance Single submitter
- CTTN p.Tyr433Cys Uncertain significance Single submitter
- CTTN p.Val127Ile Uncertain significance Single submitter
- CTTN p.Val164Leu Uncertain significance Single submitter
- CTTN p.Val164Met Uncertain significance Single submitter
All CTTN variants
Likely benign 7
- p.Val340Gly Multiple submitters
- c.*1161T>C Single submitter
- c.*397G>A Single submitter
- p.Ala481Thr Single submitter
- p.Asp527= Single submitter
- p.Gly159= Single submitter
- p.Val533Leu Single submitter
Uncertain significance 89
- c.*1144C>G Single submitter
- c.*1145C>T Single submitter
- c.*1154G>A Single submitter
- c.*1164C>T Single submitter
- c.*1167C>T Single submitter
- c.*1173G>A Single submitter
- c.*1185G>A Single submitter
- c.*1226T>C Single submitter
- c.*1242C>G Single submitter
- c.*309G>A Single submitter
- c.*317G>A Single submitter
- c.*325_*326del Single submitter
- c.*335G>C Single submitter
- c.*357G>T Single submitter
- c.*362C>T Single submitter
- c.*375G>C Single submitter
- c.*402T>G Single submitter
- c.*420A>C Single submitter
- c.*426G>A Single submitter
- c.*446T>G Single submitter
- c.*465G>A Single submitter
- c.*468G>T Single submitter
- c.*498C>A Single submitter
- c.*508T>G Single submitter
- c.*520C>G Single submitter
- c.*563G>A Single submitter
- c.*569G>T Single submitter
- c.*572C>T Single submitter
- p.Ala17Val Single submitter ⚠
- p.Ala19Ser Single submitter ⚠
- p.Ala395Gly Single submitter ⚠
- p.Ala424Val Single submitter ⚠
- p.Arg316Gln Single submitter ⚠
- p.Arg316Trp Single submitter ⚠
- p.Arg367Gln Single submitter ⚠
- p.Arg376Gln Single submitter ⚠
- p.Arg381Gln Single submitter ⚠
- p.Arg454Gln Single submitter ⚠
- p.Asp25His Single submitter ⚠
- p.Asp365Glu Single submitter ⚠
- p.Asp487Asn Single submitter ⚠
- p.Asp508Asn Single submitter ⚠
- p.Gln216Lys Single submitter ⚠
- p.Gln243Lys Single submitter ⚠
- p.Gln363His Single submitter ⚠
- p.Gln459Arg Single submitter ⚠
- p.Gln459Pro Single submitter ⚠
- p.Glu146Gln Single submitter ⚠
- p.Glu254Asp Single submitter ⚠
- p.Glu341Lys Single submitter ⚠
- p.Glu385Gln Single submitter ⚠
- p.Glu443Asp Single submitter ⚠
- p.Glu488Asp Single submitter ⚠
- p.Glu60Asp Single submitter ⚠
- p.Gly143Arg Single submitter ⚠
- p.Gly197Ser Single submitter ⚠
- p.Gly307Ser Single submitter ⚠
- p.Gly308Arg Single submitter ⚠
- p.His478Arg Single submitter ⚠
- p.His56Arg Single submitter ⚠
- p.His82Tyr Single submitter ⚠
- p.Ile350Val Single submitter ⚠
- p.Leu391Gln Single submitter ⚠
- p.Lys161Arg Single submitter ⚠
- p.Lys171Arg Single submitter ⚠
- p.Lys193Arg Single submitter ⚠
- p.Lys193Thr Single submitter ⚠
- p.Lys221Arg Single submitter ⚠
- p.Phe306Val Single submitter ⚠
- p.Pro476Leu Single submitter ⚠
- p.Pro480Ser Single submitter ⚠
- p.Pro480Thr Single submitter ⚠
- p.Ser155Cys Single submitter ⚠
- p.Ser303Cys Single submitter ⚠
- p.Ser418Arg Single submitter ⚠
- p.Ser458Arg Single submitter ⚠
- p.Ser98Leu Single submitter ⚠
- p.Thr219Met Single submitter ⚠
- p.Thr323Ala Single submitter ⚠
- p.Thr399Met Single submitter ⚠
- p.Thr440Pro Single submitter ⚠
- p.Tyr162Cys Single submitter ⚠
- p.Tyr421Cys Single submitter ⚠
- p.Tyr433Cys Single submitter ⚠
- p.Val115Met Single submitter ⚠
- p.Val127Ile Single submitter ⚠
- p.Val164Leu Single submitter ⚠
- p.Val164Met Single submitter ⚠
- p.Val445Ala Single submitter ⚠