CTU1 — 70 ClinVar variants
All ClinVar germline CTU1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
4 Likely benign · 66 Uncertain significance
Full CTU1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTU1 p.Ala131Val Uncertain significance Single submitter
- CTU1 p.Ala154Pro Uncertain significance Single submitter
- CTU1 p.Ala206Thr Uncertain significance Single submitter
- CTU1 p.Ala294Thr Uncertain significance Single submitter
- CTU1 p.Ala303Ser Uncertain significance Single submitter
- CTU1 p.Ala303Thr Uncertain significance Single submitter
- CTU1 p.Ala337Thr Uncertain significance Single submitter
- CTU1 p.Arg186Trp Uncertain significance Single submitter
- CTU1 p.Arg18Cys Uncertain significance Single submitter
- CTU1 p.Arg211Gly Uncertain significance Single submitter
- CTU1 p.Arg314His Uncertain significance Single submitter
- CTU1 p.Arg322Gly Uncertain significance Single submitter
- CTU1 p.Cys237Gly Uncertain significance Single submitter
- CTU1 p.Glu271Gly Uncertain significance Single submitter
- CTU1 p.Gly170Asp Uncertain significance Single submitter
- CTU1 p.Gly197Ala Uncertain significance Single submitter
- CTU1 p.Gly246Val Uncertain significance Single submitter
- CTU1 p.Gly285Ser Uncertain significance Single submitter
- CTU1 p.Leu25Pro Uncertain significance Single submitter
- CTU1 p.Leu324Val Uncertain significance Single submitter
- CTU1 p.Met176Val Uncertain significance Single submitter
- CTU1 p.Phe34Tyr Uncertain significance Single submitter
- CTU1 p.Pro19Arg Uncertain significance Single submitter
- CTU1 p.Pro212Arg Uncertain significance Single submitter
- CTU1 p.Pro282Arg Uncertain significance Single submitter
- CTU1 p.Pro339Ser Uncertain significance Single submitter
- CTU1 p.Pro346Ser Uncertain significance Single submitter
Predictors split 40
The independent predictors disagree with each other — read with care.
- CTU1 p.Ala131Gly Uncertain significance Single submitter
- CTU1 p.Ala131Ser Uncertain significance Single submitter
- CTU1 p.Ala154Gly Uncertain significance Single submitter
- CTU1 p.Ala240Thr Uncertain significance Single submitter
- CTU1 p.Ala276Val Uncertain significance Single submitter
- CTU1 p.Ala278Thr Uncertain significance Single submitter
- CTU1 p.Ala279Glu Uncertain significance Single submitter
- CTU1 p.Ala279Thr Uncertain significance Single submitter
- CTU1 p.Ala52Thr Uncertain significance Single submitter
- CTU1 p.Ala58Thr Uncertain significance Single submitter
- CTU1 p.Arg160Cys Uncertain significance Single submitter
- CTU1 p.Arg161Ser Uncertain significance Single submitter
- CTU1 p.Arg17Pro Uncertain significance Single submitter
- CTU1 p.Arg228Cys Uncertain significance Single submitter
- CTU1 p.Arg272Cys Uncertain significance Single submitter
- CTU1 p.Arg296His Uncertain significance Single submitter
- CTU1 p.Arg296Ser Uncertain significance Single submitter
- CTU1 p.Asp231Asn Uncertain significance Single submitter
- CTU1 p.Gln105Arg Uncertain significance Single submitter
- CTU1 p.Gln105Lys Uncertain significance Single submitter
- CTU1 p.Glu236Lys Uncertain significance Single submitter
- CTU1 p.Glu35Gln Uncertain significance Single submitter
- CTU1 p.Gly197Asp Uncertain significance Single submitter
- CTU1 p.Gly202Ser Uncertain significance Single submitter
- CTU1 p.Gly204Trp Uncertain significance Single submitter
- CTU1 p.Gly204Val Uncertain significance Single submitter
- CTU1 p.Gly205Asp Uncertain significance Single submitter
- CTU1 p.Leu223Met Uncertain significance Single submitter
- CTU1 p.Leu39Met Uncertain significance Single submitter
- CTU1 p.Phe215Leu Likely benign Single submitter
- CTU1 p.Pro19Leu Uncertain significance Single submitter
- CTU1 p.Pro284Ser Uncertain significance Single submitter
- CTU1 p.Pro49Leu Uncertain significance Single submitter
- CTU1 p.Ser200Phe Uncertain significance Single submitter
- CTU1 p.Ser234Pro Uncertain significance Single submitter
- CTU1 p.Thr65Met Uncertain significance Single submitter
- CTU1 p.Val115Ile Uncertain significance Single submitter
- CTU1 p.Val130Met Uncertain significance Single submitter
- CTU1 p.Val70Met Uncertain significance Single submitter
- CTU1 p.Val85Ala Uncertain significance Single submitter
All CTU1 variants
Likely benign 4
- p.Ala341Thr Single submitter
- p.Arg17= Single submitter
- p.Arg283Pro Single submitter
- p.Phe215Leu Single submitter ⚠
Uncertain significance 66
- p.Ala131Gly Single submitter ⚠
- p.Ala131Ser Single submitter ⚠
- p.Ala131Val Single submitter ⚠
- p.Ala154Gly Single submitter ⚠
- p.Ala154Pro Single submitter ⚠
- p.Ala206Thr Single submitter ⚠
- p.Ala240Thr Single submitter ⚠
- p.Ala276Val Single submitter ⚠
- p.Ala278Thr Single submitter ⚠
- p.Ala279Glu Single submitter ⚠
- p.Ala279Thr Single submitter ⚠
- p.Ala294Thr Single submitter ⚠
- p.Ala303Ser Single submitter ⚠
- p.Ala303Thr Single submitter ⚠
- p.Ala337Thr Single submitter ⚠
- p.Ala52Thr Single submitter ⚠
- p.Ala58Thr Single submitter ⚠
- p.Arg160Cys Single submitter ⚠
- p.Arg161Ser Single submitter ⚠
- p.Arg17Pro Single submitter ⚠
- p.Arg186Trp Single submitter ⚠
- p.Arg18Cys Single submitter ⚠
- p.Arg211Gly Single submitter ⚠
- p.Arg228Cys Single submitter ⚠
- p.Arg272Cys Single submitter ⚠
- p.Arg296His Single submitter ⚠
- p.Arg296Ser Single submitter ⚠
- p.Arg314His Single submitter ⚠
- p.Arg322Gly Single submitter ⚠
- p.Asp231Asn Single submitter ⚠
- p.Cys237Gly Single submitter ⚠
- p.Gln105Arg Single submitter ⚠
- p.Gln105Lys Single submitter ⚠
- p.Glu236Lys Single submitter ⚠
- p.Glu271Gly Single submitter ⚠
- p.Glu35Gln Single submitter ⚠
- p.Gly170Asp Single submitter ⚠
- p.Gly197Ala Single submitter ⚠
- p.Gly197Asp Single submitter ⚠
- p.Gly202Ser Single submitter ⚠
- p.Gly204Trp Single submitter ⚠
- p.Gly204Val Single submitter ⚠
- p.Gly205Asp Single submitter ⚠
- p.Gly246Val Single submitter ⚠
- p.Gly285Ser Single submitter ⚠
- p.Leu223Met Single submitter ⚠
- p.Leu25Pro Single submitter ⚠
- p.Leu324Val Single submitter ⚠
- p.Leu39Met Single submitter ⚠
- p.Met176Val Single submitter ⚠
- p.Phe34Tyr Single submitter ⚠
- p.Pro19Arg Single submitter ⚠
- p.Pro19Leu Single submitter ⚠
- p.Pro212Arg Single submitter ⚠
- p.Pro282Arg Single submitter ⚠
- p.Pro284Ser Single submitter ⚠
- p.Pro339Ser Single submitter ⚠
- p.Pro346Ser Single submitter ⚠
- p.Pro49Leu Single submitter ⚠
- p.Ser200Phe Single submitter ⚠
- p.Ser234Pro Single submitter ⚠
- p.Thr65Met Single submitter ⚠
- p.Val115Ile Single submitter ⚠
- p.Val130Met Single submitter ⚠
- p.Val70Met Single submitter ⚠
- p.Val85Ala Single submitter ⚠