CTXN3 — 9 ClinVar variants
All ClinVar germline CTXN3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
9 Uncertain significance
Full CTXN3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CTXN3 p.Arg47Trp Uncertain significance Single submitter
- CTXN3 p.Glu26Lys Uncertain significance Single submitter
- CTXN3 p.Met23Thr Uncertain significance Single submitter
- CTXN3 p.Pro13Thr Uncertain significance Single submitter
- CTXN3 p.Thr61Asn Uncertain significance Single submitter
- CTXN3 p.Val32Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All CTXN3 variants
Uncertain significance 9
- p.Arg47Gln Single submitter ⚠
- p.Arg47Trp Single submitter ⚠
- p.Glu26Lys Single submitter ⚠
- p.Met23Thr Single submitter ⚠
- p.Met59Ile Single submitter ⚠
- p.Pro13Thr Single submitter ⚠
- p.Thr61Asn Single submitter ⚠
- p.Thr63Ile Single submitter ⚠
- p.Val32Ile Single submitter ⚠