CUEDC2 — 40 ClinVar variants
All ClinVar germline CUEDC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
1 Likely benign · 39 Uncertain significance
Full CUEDC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CUEDC2 p.Ala226Ser Uncertain significance Single submitter
- CUEDC2 p.Ala69Thr Uncertain significance Single submitter
- CUEDC2 p.Arg116Gln Uncertain significance Single submitter
- CUEDC2 p.Arg202Lys Uncertain significance Single submitter
- CUEDC2 p.Arg264Gly Uncertain significance Single submitter
- CUEDC2 p.Asp136Asn Uncertain significance Single submitter
- CUEDC2 p.Asp150Glu Uncertain significance Single submitter
- CUEDC2 p.Asp228Tyr Uncertain significance Single submitter
- CUEDC2 p.Gln163Arg Uncertain significance Single submitter
- CUEDC2 p.Glu112Ala Uncertain significance Single submitter
- CUEDC2 p.Glu137Lys Uncertain significance Single submitter
- CUEDC2 p.Glu227Asp Uncertain significance Single submitter
- CUEDC2 p.Glu270Asp Uncertain significance Single submitter
- CUEDC2 p.Glu94Asp Uncertain significance Single submitter
- CUEDC2 p.Ile31Val Uncertain significance Single submitter
- CUEDC2 p.Lys170Arg Uncertain significance Single submitter
- CUEDC2 p.Met54Ile Uncertain significance Single submitter
- CUEDC2 p.Met54Leu Uncertain significance Single submitter
- CUEDC2 p.Phe32Ile Uncertain significance Single submitter
- CUEDC2 p.Pro201Ser Uncertain significance Single submitter
- CUEDC2 p.Ser225Asn Uncertain significance Single submitter
- CUEDC2 p.Ser254Gly Uncertain significance Single submitter
- CUEDC2 p.Trp193Ser Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- CUEDC2 p.Ala56Val Uncertain significance Single submitter
- CUEDC2 p.Ala9Val Uncertain significance Single submitter
- CUEDC2 p.Arg116Trp Uncertain significance Single submitter
- CUEDC2 p.Arg172Trp Uncertain significance Single submitter
- CUEDC2 p.Arg233Gln Uncertain significance Single submitter
- CUEDC2 p.Arg233Trp Uncertain significance Single submitter
- CUEDC2 p.Arg264Trp Uncertain significance Single submitter
- CUEDC2 p.Asp174Gly Uncertain significance Single submitter
- CUEDC2 p.Asp23Asn Uncertain significance Single submitter
- CUEDC2 p.Asp89Asn Uncertain significance Single submitter
- CUEDC2 p.Gln135His Uncertain significance Single submitter
- CUEDC2 p.Glu118Lys Uncertain significance Single submitter
- CUEDC2 p.Glu269Lys Uncertain significance Single submitter
- CUEDC2 p.Leu120Phe Uncertain significance Single submitter
- CUEDC2 p.Leu212Met Uncertain significance Single submitter
- CUEDC2 p.Pro20Ser Uncertain significance Single submitter
All CUEDC2 variants
Likely benign 1
- p.Ala141Thr Single submitter
Uncertain significance 39
- p.Ala226Ser Single submitter ⚠
- p.Ala56Val Single submitter ⚠
- p.Ala69Thr Single submitter ⚠
- p.Ala9Val Single submitter ⚠
- p.Arg116Gln Single submitter ⚠
- p.Arg116Trp Single submitter ⚠
- p.Arg172Trp Single submitter ⚠
- p.Arg202Lys Single submitter ⚠
- p.Arg233Gln Single submitter ⚠
- p.Arg233Trp Single submitter ⚠
- p.Arg264Gly Single submitter ⚠
- p.Arg264Trp Single submitter ⚠
- p.Asp136Asn Single submitter ⚠
- p.Asp150Glu Single submitter ⚠
- p.Asp174Gly Single submitter ⚠
- p.Asp228Tyr Single submitter ⚠
- p.Asp23Asn Single submitter ⚠
- p.Asp89Asn Single submitter ⚠
- p.Gln135His Single submitter ⚠
- p.Gln163Arg Single submitter ⚠
- p.Glu112Ala Single submitter ⚠
- p.Glu118Lys Single submitter ⚠
- p.Glu137Lys Single submitter ⚠
- p.Glu227Asp Single submitter ⚠
- p.Glu269Lys Single submitter ⚠
- p.Glu270Asp Single submitter ⚠
- p.Glu94Asp Single submitter ⚠
- p.Ile31Val Single submitter ⚠
- p.Leu120Phe Single submitter ⚠
- p.Leu212Met Single submitter ⚠
- p.Lys170Arg Single submitter ⚠
- p.Met54Ile Single submitter ⚠
- p.Met54Leu Single submitter ⚠
- p.Phe32Ile Single submitter ⚠
- p.Pro201Ser Single submitter ⚠
- p.Pro20Ser Single submitter ⚠
- p.Ser225Asn Single submitter ⚠
- p.Ser254Gly Single submitter ⚠
- p.Trp193Ser Single submitter ⚠