CUL1 — 24 ClinVar variants
All ClinVar germline CUL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
24 Uncertain significance
Full CUL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 16
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CUL1 p.Ala266Ser Uncertain significance Single submitter
- CUL1 p.Ala656Val Uncertain significance Single submitter
- CUL1 p.Ala65Val Uncertain significance Single submitter
- CUL1 p.Arg321His Uncertain significance Single submitter
- CUL1 p.Arg5Gln Uncertain significance Single submitter
- CUL1 p.Asn102Asp Uncertain significance Single submitter
- CUL1 p.Asn102Ser Uncertain significance Single submitter
- CUL1 p.Gln737Leu Uncertain significance Single submitter
- CUL1 p.Gly543Arg Uncertain significance Single submitter
- CUL1 p.Leu640Ile Uncertain significance Single submitter
- CUL1 p.Leu648Pro Uncertain significance Single submitter
- CUL1 p.Lys515Glu Uncertain significance Single submitter
- CUL1 p.Lys522Arg Uncertain significance Single submitter
- CUL1 p.Thr249Ala Uncertain significance Single submitter
- CUL1 p.Trp144Ser Uncertain significance Single submitter
- CUL1 p.Tyr157Cys Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All CUL1 variants
Uncertain significance 24
- c.141-1G>A Single submitter
- p.Ala266Ser Single submitter ⚠
- p.Ala656Val Single submitter ⚠
- p.Ala65Val Single submitter ⚠
- p.Arg321His Single submitter ⚠
- p.Arg5Gln Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Arg63Ter Single submitter
- p.Asn102Asp Single submitter ⚠
- p.Asn102Ser Single submitter ⚠
- p.Asp125Gly Single submitter ⚠
- p.Gln35Pro Single submitter ⚠
- p.Gln737Leu Single submitter ⚠
- p.Glu271Ter Single submitter
- p.Glu589Asp Single submitter ⚠
- p.Gly543Arg Single submitter ⚠
- p.Leu640Ile Single submitter ⚠
- p.Leu648Pro Single submitter ⚠
- p.Lys515Glu Single submitter ⚠
- p.Lys522Arg Single submitter ⚠
- p.Phe498Leu Single submitter ⚠
- p.Thr249Ala Single submitter ⚠
- p.Trp144Ser Single submitter ⚠
- p.Tyr157Cys Single submitter ⚠