CUL2 — 76 ClinVar variants
All ClinVar germline CUL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
1 Likely pathogenic · 4 Benign · 1 Likely benign · 70 Uncertain significance
Full CUL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CUL2 p.Ala403Val Uncertain significance Single submitter
- CUL2 p.Ala522Val Uncertain significance Single submitter
- CUL2 p.Ala634Ser Uncertain significance Single submitter
- CUL2 p.Ala671Ser Uncertain significance Single submitter
- CUL2 p.Ala671Val Uncertain significance Single submitter
- CUL2 p.Arg161Gln Uncertain significance Single submitter
- CUL2 p.Arg171His Uncertain significance Single submitter
- CUL2 p.Arg251Gln Uncertain significance Single submitter
- CUL2 p.Arg269Gly Uncertain significance Single submitter
- CUL2 p.Arg287Gln Uncertain significance Single submitter
- CUL2 p.Arg691Gln Uncertain significance Single submitter
- CUL2 p.Arg70Gln Uncertain significance Single submitter
- CUL2 p.Asn133Ser Uncertain significance Single submitter
- CUL2 p.Asn15Lys Uncertain significance Single submitter
- CUL2 p.Asn15Ser Uncertain significance Single submitter
- CUL2 p.Asn329Ser Uncertain significance Single submitter
- CUL2 p.Asn397Ser Uncertain significance Single submitter
- CUL2 p.Asn492Ser Uncertain significance Single submitter
- CUL2 p.Asp673Val Uncertain significance Single submitter
- CUL2 p.Asp739Gly Uncertain significance Single submitter
- CUL2 p.Glu246Asp Uncertain significance Single submitter
- CUL2 p.Glu598Asp Uncertain significance Single submitter
- CUL2 p.Gly323Ala Uncertain significance Single submitter
- CUL2 p.His190Arg Uncertain significance Single submitter
- CUL2 p.His320Arg Uncertain significance Single submitter
- CUL2 p.His71Tyr Uncertain significance Single submitter
- CUL2 p.His73Arg Uncertain significance Single submitter
- CUL2 p.Ile158Val Uncertain significance Single submitter
- CUL2 p.Ile21Val Uncertain significance Single submitter
- CUL2 p.Ile425Val Uncertain significance Single submitter
- CUL2 p.Ile509Val Uncertain significance Single submitter
- CUL2 p.Ile718Thr Uncertain significance Single submitter
- CUL2 p.Leu123Ile Uncertain significance Single submitter
- CUL2 p.Leu301Val Uncertain significance Single submitter
- CUL2 p.Lys441Arg Uncertain significance Single submitter
- CUL2 p.Lys74Gln Uncertain significance Single submitter
- CUL2 p.Met335Val Uncertain significance Single submitter
- CUL2 p.Met480Arg Uncertain significance Single submitter
- CUL2 p.Met678Ile Uncertain significance Single submitter
- CUL2 p.Met86Thr Uncertain significance Single submitter
- CUL2 p.Phe207Val Uncertain significance Single submitter
- CUL2 p.Phe211Leu Uncertain significance Single submitter
- CUL2 p.Ser187Cys Uncertain significance Single submitter
- CUL2 p.Ser656Pro Uncertain significance Single submitter
- CUL2 p.Ser742Ile Uncertain significance Single submitter
- CUL2 p.Thr337Ala Uncertain significance Single submitter
- CUL2 p.Thr578Lys Uncertain significance Single submitter
- CUL2 p.Thr611Ile Uncertain significance Single submitter
- CUL2 p.Tyr477Phe Uncertain significance Single submitter
- CUL2 p.Val24Met Uncertain significance Single submitter
- CUL2 p.Val299Ala Uncertain significance Single submitter
- CUL2 p.Val299Ile Uncertain significance Single submitter
- CUL2 p.Val594Ile Uncertain significance Single submitter
- CUL2 p.Val744Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- CUL2 p.Arg302Cys Uncertain significance Single submitter
- CUL2 p.Arg302His Uncertain significance Single submitter
- CUL2 p.Arg708Gly Uncertain significance Single submitter
- CUL2 p.Arg708Ser Uncertain significance Single submitter
- CUL2 p.Arg70Trp Uncertain significance Single submitter
- CUL2 p.Asn317Asp Uncertain significance Single submitter
- CUL2 p.Gly172Val Uncertain significance Single submitter
- CUL2 p.His88Arg Uncertain significance Single submitter
- CUL2 p.Leu212Met Uncertain significance Single submitter
- CUL2 p.Phe198Leu Uncertain significance Single submitter
- CUL2 p.Pro210Ser Uncertain significance Single submitter
- CUL2 p.Ser305Thr Uncertain significance Single submitter
- CUL2 p.Ser737Leu Uncertain significance Single submitter
- CUL2 p.Thr19Met Uncertain significance Single submitter
All CUL2 variants
Likely pathogenic 1
- p.Ile731Thr No assertion criteria Moyamoya angiopathy
Benign 4
- p.Arg148= Multiple submitters
- c.222+4A>G Single submitter
- c.506+7G>C Single submitter
- p.Thr526= Single submitter
Likely benign 1
- p.Met335Ile Single submitter
Uncertain significance 70
- c.-22-2881A>G Single submitter
- c.-2C>A Single submitter
- p.Ala403Val Single submitter ⚠
- p.Ala522Val Single submitter ⚠
- p.Ala634Ser Single submitter ⚠
- p.Ala671Ser Single submitter ⚠
- p.Ala671Val Single submitter ⚠
- p.Arg161Gln Single submitter ⚠
- p.Arg171His Single submitter ⚠
- p.Arg251Gln Single submitter ⚠
- p.Arg269Gly Single submitter ⚠
- p.Arg287Gln Single submitter ⚠
- p.Arg302Cys Single submitter ⚠
- p.Arg302His Single submitter ⚠
- p.Arg691Gln Single submitter ⚠
- p.Arg708Gly Single submitter ⚠
- p.Arg708Ser Single submitter ⚠
- p.Arg70Gln Single submitter ⚠
- p.Arg70Trp Single submitter ⚠
- p.Asn133Ser Single submitter ⚠
- p.Asn15Lys Single submitter ⚠
- p.Asn15Ser Single submitter ⚠
- p.Asn317Asp Single submitter ⚠
- p.Asn329Ser Single submitter ⚠
- p.Asn397Ser Single submitter ⚠
- p.Asn492Ser Single submitter ⚠
- p.Asp673Val Single submitter ⚠
- p.Asp739Gly Single submitter ⚠
- p.Glu246Asp Single submitter ⚠
- p.Glu598Asp Single submitter ⚠
- p.Gly172Val Single submitter ⚠
- p.Gly323Ala Single submitter ⚠
- p.His190Arg Single submitter ⚠
- p.His320Arg Single submitter ⚠
- p.His71Tyr Single submitter ⚠
- p.His73Arg Single submitter ⚠
- p.His88Arg Single submitter ⚠
- p.Ile158Val Single submitter ⚠
- p.Ile21Val Single submitter ⚠
- p.Ile425Val Single submitter ⚠
- p.Ile509Val Single submitter ⚠
- p.Ile718Thr Single submitter ⚠
- p.Leu123Ile Single submitter ⚠
- p.Leu212Met Single submitter ⚠
- p.Leu301Val Single submitter ⚠
- p.Lys441Arg Single submitter ⚠
- p.Lys74Gln Single submitter ⚠
- p.Met335Val Single submitter ⚠
- p.Met480Arg Single submitter ⚠
- p.Met678Ile Single submitter ⚠
- p.Met86Thr Single submitter ⚠
- p.Phe198Leu Single submitter ⚠
- p.Phe207Val Single submitter ⚠
- p.Phe211Leu Single submitter ⚠
- p.Pro210Ser Single submitter ⚠
- p.Ser187Cys Single submitter ⚠
- p.Ser305Thr Single submitter ⚠
- p.Ser656Pro Single submitter ⚠
- p.Ser737Leu Single submitter ⚠
- p.Ser742Ile Single submitter ⚠
- p.Thr19Met Single submitter ⚠
- p.Thr337Ala Single submitter ⚠
- p.Thr578Lys Single submitter ⚠
- p.Thr611Ile Single submitter ⚠
- p.Tyr477Phe Single submitter ⚠
- p.Val24Met Single submitter ⚠
- p.Val299Ala Single submitter ⚠
- p.Val299Ile Single submitter ⚠
- p.Val594Ile Single submitter ⚠
- p.Val744Ala Single submitter ⚠