CUL4A — 69 ClinVar variants
All ClinVar germline CUL4A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
3 Likely benign · 66 Uncertain significance
Full CUL4A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CUL4A p.Ala13Pro Uncertain significance Single submitter
- CUL4A p.Ala208Val Uncertain significance Single submitter
- CUL4A p.Arg80Lys Uncertain significance Single submitter
- CUL4A p.Asp56Glu Uncertain significance Single submitter
- CUL4A p.Gln189Arg Uncertain significance Single submitter
- CUL4A p.Gly195Val Uncertain significance Single submitter
- CUL4A p.Gly206Ser Uncertain significance Single submitter
- CUL4A p.Gly35Arg Uncertain significance Single submitter
- CUL4A p.Gly585Glu Uncertain significance Single submitter
- CUL4A p.Gly607Ala Uncertain significance Single submitter
- CUL4A p.Ile147Val Uncertain significance Single submitter
- CUL4A p.Ile149Asn Uncertain significance Single submitter
- CUL4A p.Ile353Val Uncertain significance Single submitter
- CUL4A p.Leu242Ser Uncertain significance Single submitter
- CUL4A p.Leu86Val Uncertain significance Single submitter
- CUL4A p.Lys435Glu Uncertain significance Single submitter
- CUL4A p.Met187Ile Uncertain significance Single submitter
- CUL4A p.Met220Thr Uncertain significance Single submitter
- CUL4A p.Met615Thr Uncertain significance Single submitter
- CUL4A p.Pro729Leu Uncertain significance Single submitter
- CUL4A p.Ser622Gly Uncertain significance Single submitter
- CUL4A p.Ser642Asn Uncertain significance Single submitter
- CUL4A p.Ser78Phe Uncertain significance Single submitter
- CUL4A p.Thr159Ala Uncertain significance Single submitter
- CUL4A p.Thr180Ile Uncertain significance Single submitter
- CUL4A p.Thr192Ile Uncertain significance Single submitter
- CUL4A p.Thr346Ser Uncertain significance Single submitter
- CUL4A p.Val114Ile Uncertain significance Single submitter
- CUL4A p.Val638Met Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- CUL4A p.Ala486Thr Uncertain significance Single submitter
- CUL4A p.Arg144Gly Uncertain significance Single submitter
- CUL4A p.Arg202His Likely benign Single submitter
- CUL4A p.Arg385Gln Uncertain significance Single submitter
- CUL4A p.Arg49Gln Uncertain significance Single submitter
- CUL4A p.Asn603Ser Uncertain significance Single submitter
- CUL4A p.Asp185His Uncertain significance Single submitter
- CUL4A p.Gln117His Uncertain significance Single submitter
- CUL4A p.Gln324His Uncertain significance Single submitter
- CUL4A p.Gln515His Uncertain significance Single submitter
- CUL4A p.Glu201Lys Uncertain significance Single submitter
- CUL4A p.Glu232Gln Uncertain significance Single submitter
- CUL4A p.Glu237Gly Uncertain significance Single submitter
- CUL4A p.Gly16Asp Uncertain significance Single submitter
- CUL4A p.Gly38Asp Uncertain significance Single submitter
- CUL4A p.Gly519Cys Uncertain significance Single submitter
- CUL4A p.Gly9Cys Uncertain significance Single submitter
- CUL4A p.His181Arg Uncertain significance Single submitter
- CUL4A p.His67Tyr Uncertain significance Single submitter
- CUL4A p.His96Gln Uncertain significance Single submitter
- CUL4A p.Ile193Thr Uncertain significance Single submitter
- CUL4A p.Ile521Val Uncertain significance Single submitter
- CUL4A p.Ile696Val Uncertain significance Single submitter
- CUL4A p.Leu429Met Uncertain significance Single submitter
- CUL4A p.Pro120Leu Uncertain significance Single submitter
- CUL4A p.Pro34Leu Uncertain significance Single submitter
- CUL4A p.Ser128Arg Uncertain significance Single submitter
- CUL4A p.Ser184Arg Uncertain significance Single submitter
- CUL4A p.Ser281Gly Likely benign Single submitter
- CUL4A p.Ser341Arg Uncertain significance Single submitter
- CUL4A p.Ser516Asn Uncertain significance Single submitter
- CUL4A p.Thr537Met Uncertain significance Single submitter
- CUL4A p.Thr59Arg Uncertain significance Single submitter
- CUL4A p.Thr685Ala Uncertain significance Single submitter
- CUL4A p.Thr709Ala Uncertain significance Single submitter
- CUL4A p.Val188Ile Uncertain significance Single submitter
- CUL4A p.Val209Met Uncertain significance Single submitter
- CUL4A p.Val316Met Uncertain significance Single submitter
- CUL4A p.Val375Leu Uncertain significance Single submitter
All CUL4A variants
Likely benign 3
- p.Arg202His Single submitter ⚠
- p.Ser281Gly Single submitter ⚠
- p.Val387Ile Single submitter
Uncertain significance 66
- p.Ala13Pro Single submitter ⚠
- p.Ala208Val Single submitter ⚠
- p.Ala486Thr Single submitter ⚠
- p.Arg144Gly Single submitter ⚠
- p.Arg385Gln Single submitter ⚠
- p.Arg49Gln Single submitter ⚠
- p.Arg80Lys Single submitter ⚠
- p.Asn603Ser Single submitter ⚠
- p.Asp185His Single submitter ⚠
- p.Asp56Glu Single submitter ⚠
- p.Gln117His Single submitter ⚠
- p.Gln189Arg Single submitter ⚠
- p.Gln324His Single submitter ⚠
- p.Gln515His Single submitter ⚠
- p.Glu201Lys Single submitter ⚠
- p.Glu232Gln Single submitter ⚠
- p.Glu237Gly Single submitter ⚠
- p.Gly16Asp Single submitter ⚠
- p.Gly195Val Single submitter ⚠
- p.Gly206Ser Single submitter ⚠
- p.Gly35Arg Single submitter ⚠
- p.Gly38Asp Single submitter ⚠
- p.Gly519Cys Single submitter ⚠
- p.Gly585Glu Single submitter ⚠
- p.Gly607Ala Single submitter ⚠
- p.Gly9Cys Single submitter ⚠
- p.His181Arg Single submitter ⚠
- p.His67Tyr Single submitter ⚠
- p.His96Gln Single submitter ⚠
- p.Ile147Val Single submitter ⚠
- p.Ile149Asn Single submitter ⚠
- p.Ile193Thr Single submitter ⚠
- p.Ile353Val Single submitter ⚠
- p.Ile521Val Single submitter ⚠
- p.Ile696Val Single submitter ⚠
- p.Leu242Ser Single submitter ⚠
- p.Leu429Met Single submitter ⚠
- p.Leu86Val Single submitter ⚠
- p.Lys435Glu Single submitter ⚠
- p.Met187Ile Single submitter ⚠
- p.Met220Thr Single submitter ⚠
- p.Met615Thr Single submitter ⚠
- p.Pro120Leu Single submitter ⚠
- p.Pro34Leu Single submitter ⚠
- p.Pro729Leu Single submitter ⚠
- p.Ser128Arg Single submitter ⚠
- p.Ser184Arg Single submitter ⚠
- p.Ser341Arg Single submitter ⚠
- p.Ser516Asn Single submitter ⚠
- p.Ser622Gly Single submitter ⚠
- p.Ser642Asn Single submitter ⚠
- p.Ser78Phe Single submitter ⚠
- p.Thr159Ala Single submitter ⚠
- p.Thr180Ile Single submitter ⚠
- p.Thr192Ile Single submitter ⚠
- p.Thr346Ser Single submitter ⚠
- p.Thr537Met Single submitter ⚠
- p.Thr59Arg Single submitter ⚠
- p.Thr685Ala Single submitter ⚠
- p.Thr709Ala Single submitter ⚠
- p.Val114Ile Single submitter ⚠
- p.Val188Ile Single submitter ⚠
- p.Val209Met Single submitter ⚠
- p.Val316Met Single submitter ⚠
- p.Val375Leu Single submitter ⚠
- p.Val638Met Single submitter ⚠