CUL5 — 38 ClinVar variants
All ClinVar germline CUL5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
1 Benign · 1 Likely benign · 36 Uncertain significance
Full CUL5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CUL5 p.Ala324Thr Uncertain significance Single submitter
- CUL5 p.Arg253Gln Uncertain significance Single submitter
- CUL5 p.Arg350Gly Uncertain significance Single submitter
- CUL5 p.Arg700Lys Uncertain significance Single submitter
- CUL5 p.Arg98Gln Uncertain significance Single submitter
- CUL5 p.Asn153Lys Uncertain significance Single submitter
- CUL5 p.Asn5His Uncertain significance Single submitter
- CUL5 p.Asn9Asp Uncertain significance Single submitter
- CUL5 p.Asp235Glu Uncertain significance Single submitter
- CUL5 p.Asp379Val Uncertain significance Single submitter
- CUL5 p.Glu33Gln Uncertain significance Single submitter
- CUL5 p.Glu431Asp Uncertain significance Single submitter
- CUL5 p.Glu71Asp Uncertain significance Single submitter
- CUL5 p.Ile318Val Uncertain significance Single submitter
- CUL5 p.Ile530Val Uncertain significance Single submitter
- CUL5 p.Lys658Arg Uncertain significance Single submitter
- CUL5 p.Pro610Ala Uncertain significance Single submitter
- CUL5 p.Ser220Leu Uncertain significance Single submitter
- CUL5 p.Ser771Thr Uncertain significance Single submitter
- CUL5 p.Thr335Ser Uncertain significance Single submitter
- CUL5 p.Thr346Ile Uncertain significance Single submitter
- CUL5 p.Val258Ile Uncertain significance Single submitter
- CUL5 p.Val377Ile Uncertain significance Single submitter
- CUL5 p.Val588Ile Uncertain significance Single submitter
- CUL5 p.Val680Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CUL5 p.Arg247His Uncertain significance Single submitter
- CUL5 p.Asp469Asn Uncertain significance Single submitter
- CUL5 p.Glu557Gly Uncertain significance Single submitter
- CUL5 p.Leu387Phe Uncertain significance Single submitter
- CUL5 p.Lys492Asn Uncertain significance Single submitter
- CUL5 p.Pro24Leu Uncertain significance Single submitter
- CUL5 p.Val303Leu Uncertain significance Single submitter
All CUL5 variants
Benign 1
- p.Gln75= Multiple submitters
Likely benign 1
- p.Gly393= Single submitter
Uncertain significance 36
- p.Ala171Thr Single submitter
- p.Ala324Thr Single submitter ⚠
- p.Ala535Ser Single submitter
- p.Arg247His Single submitter ⚠
- p.Arg253Gln Single submitter ⚠
- p.Arg350Gly Single submitter ⚠
- p.Arg700Lys Single submitter ⚠
- p.Arg98Gln Single submitter ⚠
- p.Asn153Lys Single submitter ⚠
- p.Asn5His Single submitter ⚠
- p.Asn9Asp Single submitter ⚠
- p.Asp235Glu Single submitter ⚠
- p.Asp379Val Single submitter ⚠
- p.Asp469Asn Single submitter ⚠
- p.Glu33Gln Single submitter ⚠
- p.Glu431Asp Single submitter ⚠
- p.Glu557Gly Single submitter ⚠
- p.Glu71Asp Single submitter ⚠
- p.Gly120Val Single submitter
- p.Ile318Val Single submitter ⚠
- p.Ile530Val Single submitter ⚠
- p.Leu387Phe Single submitter ⚠
- p.Lys492Asn Single submitter ⚠
- p.Lys658Arg Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro610Ala Single submitter ⚠
- p.Ser189Cys Single submitter
- p.Ser220Leu Single submitter ⚠
- p.Ser771Thr Single submitter ⚠
- p.Thr335Ser Single submitter ⚠
- p.Thr346Ile Single submitter ⚠
- p.Val258Ile Single submitter ⚠
- p.Val303Leu Single submitter ⚠
- p.Val377Ile Single submitter ⚠
- p.Val588Ile Single submitter ⚠
- p.Val680Ile Single submitter ⚠