Sugi Variant

Sugi Variant/CUL7

CUL7 — 1034 ClinVar variants

All ClinVar germline CUL7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 422 flagged for review →

73 Pathogenic · 9 Pathogenic/Likely pathogenic · 50 Likely pathogenic · 65 Conflicting · 35 Benign · 25 Benign/Likely benign · 306 Likely benign · 471 Uncertain significance

Full CUL7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 422

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 23

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 319

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 319

Predictors split 80

The independent predictors disagree with each other — read with care.

All CUL7 variants

Pathogenic 73

Pathogenic/Likely pathogenic 9

Likely pathogenic 50

Conflicting classifications of pathogenicity 65

Benign 35

Benign/Likely benign 25

Likely benign 306

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 471

Showing the top 300 by review status; the full set is in the sitemap.