CUTA — 31 ClinVar variants
All ClinVar germline CUTA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
1 Likely benign · 30 Uncertain significance
Full CUTA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- CUTA p.Ala94Thr Uncertain significance Single submitter
- CUTA p.Arg165Cys Uncertain significance Single submitter
- CUTA p.Asn98Ile Uncertain significance Single submitter
- CUTA p.Glu144Lys Uncertain significance Single submitter
- CUTA p.Gly156Glu Uncertain significance Single submitter
- CUTA p.Ile149Thr Uncertain significance Single submitter
- CUTA p.Ile175Val Uncertain significance Single submitter
- CUTA p.Pro159Leu Uncertain significance Single submitter
- CUTA p.Pro38Ser Uncertain significance Single submitter
- CUTA p.Pro50Ser Uncertain significance Single submitter
- CUTA p.Ser139Pro Uncertain significance Single submitter
- CUTA p.Ser69Phe Uncertain significance Single submitter
- CUTA p.Thr168Ala Uncertain significance Single submitter
- CUTA p.Val130Ala Uncertain significance Single submitter
- CUTA p.Val145Met Uncertain significance Single submitter
- CUTA p.Val68Ile Uncertain significance Single submitter
- CUTA p.Val73Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- CUTA p.Arg138Cys Uncertain significance Single submitter
- CUTA p.Pro29Leu Uncertain significance Single submitter
- CUTA p.Pro65Ser Uncertain significance Single submitter
- CUTA p.Ser172Cys Uncertain significance Single submitter
- CUTA p.Ser54Trp Uncertain significance Single submitter
- CUTA p.Thr134Arg Uncertain significance Single submitter
- CUTA p.Val73Ile Uncertain significance Single submitter
All CUTA variants
Likely benign 1
- p.Arg86= Single submitter
Uncertain significance 30
- c.44C>A Single submitter
- p.Ala12Val Single submitter
- p.Ala94Thr Single submitter ⚠
- p.Arg138Cys Single submitter ⚠
- p.Arg165Cys Single submitter ⚠
- p.Asn98Ile Single submitter ⚠
- p.Glu144Lys Single submitter ⚠
- p.Gly10Glu Single submitter
- p.Gly13Arg Single submitter
- p.Gly156Glu Single submitter ⚠
- p.Ile149Thr Single submitter ⚠
- p.Ile175Val Single submitter ⚠
- p.Ile2Leu Single submitter
- p.Pro159Leu Single submitter ⚠
- p.Pro29Leu Single submitter ⚠
- p.Pro38Ser Single submitter ⚠
- p.Pro50Ser Single submitter ⚠
- p.Pro65Ser Single submitter ⚠
- p.Ser139Pro Single submitter ⚠
- p.Ser172Cys Single submitter ⚠
- p.Ser54Trp Single submitter ⚠
- p.Ser69Phe Single submitter ⚠
- p.Thr134Arg Single submitter ⚠
- p.Thr168Ala Single submitter ⚠
- p.Thr20Ala Single submitter
- p.Val130Ala Single submitter ⚠
- p.Val145Met Single submitter ⚠
- p.Val68Ile Single submitter ⚠
- p.Val73Ile Single submitter ⚠
- p.Val73Leu Single submitter ⚠